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American Academy of Pediatrics
Article

Global Burden of Childhood Epilepsy, Intellectual Disability, and Sensory Impairments

Bolajoko O. Olusanya, Scott M. Wright, M.K.C. Nair, Nem-Yun Boo, Ricardo Halpern, Hannah Kuper, Amina A. Abubakar, Nihad A. Almasri, Jalal Arabloo, Narendra K. Arora, Sophia Backhaus, Brad D. Berman, Cecilia Breinbauer, Gwen Carr, Petrus J. de Vries, Christie del Castillo-Hegyi, Aziz Eftekhari, Melissa J. Gladstone, Rosa A. Hoekstra, Vijaya Kancherla, Mphelekedzeni C. Mulaudzi, Angelina Kakooza-Mwesige, Felix A. Ogbo, Helen E. Olsen, Jacob O. Olusanya, Ashok Pandey, Maureen E. Samms-Vaughan, Chiara Servili, Amira Shaheen, Tracey Smythe, Donald Wertlieb, Andrew N. Williams, Charles R.J. Newton, Adrian C. Davis, Nicholas J. Kassebaum and on behalf of the Global Research on Developmental Disabilities Collaborators (GRDDC)
Pediatrics July 2020, 146 (1) e20192623; DOI: https://doi.org/10.1542/peds.2019-2623
Bolajoko O. Olusanya
aCentre for Healthy Start Initiative, Lagos, Nigeria;
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Scott M. Wright
bDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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M.K.C. Nair
cNIMS Spectrum Child Development Research Centre, NIMS Medicity, Thiruvananthapuram, Kerala, India;
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Nem-Yun Boo
dDepartment of Population Medicine, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Selangor, Malaysia;
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Ricardo Halpern
eDepartment of Pediatrics and Adolescence, University of Health Sciences of Porto Alegre, Porto Alegrel, Brazil;
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Hannah Kuper
fInternational Centre for Evidence in Disability, London School of Hygiene and Tropical Medicine, London, United Kingdom;
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Amina A. Abubakar
gKenya Medical Research Institute–Wellcome Trust Research Programme, Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, KiIifi, Kenya;
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Nihad A. Almasri
hDepartment of Physiotherapy, School of Rehabilitation Sciences, The University of Jordan, Amman, Jordan;
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Jalal Arabloo
iHealth Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran;
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Narendra K. Arora
jThe INCLEN Trust International, New Delhi, India;
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Sophia Backhaus
kCentre for Evidence-Based Intervention, Department of Social Policy and Intervention, University of Oxford, Oxford, United Kingdom;
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Brad D. Berman
lDepartment of Pediatrics, University of California, San Francisco Benioff Children’s Hospital, San Francisco, California;
mProgressions: Developmental and Behavioral Pediatrics, San Francisco, California;
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Cecilia Breinbauer
nCenter for Healthy Development, Seattle, Washington;
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Gwen Carr
oEar Institute, University College London, London, United Kingdom;
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Petrus J. de Vries
pDivision of Child and Adolescent Psychiatry, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa;
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Christie del Castillo-Hegyi
qDepartment of Emergency Medicine, CHI St. Vincent, Little Rock, Arkansas;
rFed Is Best Foundation, Little Rock, Arkansas;
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Aziz Eftekhari
sDepartment of Pharmacology and Toxicology, Maragheh University of Medical Sciences, Maragheh, Iran;
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Melissa J. Gladstone
tInstitute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom;
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Rosa A. Hoekstra
uDepartment of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom;
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Vijaya Kancherla
vDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia;
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Mphelekedzeni C. Mulaudzi
wDepartment of Paediatrics and Child Health, University of the Witwatersrand, Johannesburg, Johannesburg, South Africa;
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Angelina Kakooza-Mwesige
xDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda;
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Felix A. Ogbo
yTranslational Health Research Institute, School of Medicine, Western Sydney University, Campbelltown Campus, Penrith, New South Wales, Australia;
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Helen E. Olsen
zBill and Melinda Gates Foundation, Seattle, Washington;
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Jacob O. Olusanya
aCentre for Healthy Start Initiative, Lagos, Nigeria;
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Ashok Pandey
aaNepal Health Research Council, Kathmandu, Nepal;
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Maureen E. Samms-Vaughan
bbDepartment of Child and Adolescent Health, The University of the West Indies, Mona Campus, Kingston, Jamaica;
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Chiara Servili
ccDepartment of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland;
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Amira Shaheen
ddDivision of Public Health, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine;
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Tracey Smythe
fInternational Centre for Evidence in Disability, London School of Hygiene and Tropical Medicine, London, United Kingdom;
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Donald Wertlieb
eeEliot-Pearson Department of Child Development, Tufts University, Medford, Massachusetts;
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Andrew N. Williams
ffVirtual Academic Unit, Northampton General Hospital, Northampton, United Kingdom; and
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Charles R.J. Newton
gKenya Medical Research Institute–Wellcome Trust Research Programme, Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, KiIifi, Kenya;
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Adrian C. Davis
oEar Institute, University College London, London, United Kingdom;
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Nicholas J. Kassebaum
ggInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington
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Abstract

BACKGROUND: Estimates of children and adolescents with disabilities worldwide are needed to inform global intervention under the disability-inclusive provisions of the Sustainable Development Goals. We sought to update the most widely reported estimate of 93 million children <15 years with disabilities from the Global Burden of Disease Study 2004.

METHODS: We analyzed Global Burden of Disease Study 2017 data on the prevalence of childhood epilepsy, intellectual disability, and vision or hearing loss and on years lived with disability (YLD) derived from systematic reviews, health surveys, hospital and claims databases, cohort studies, and disease-specific registries. Point estimates of the prevalence and YLD and the 95% uncertainty intervals (UIs) around the estimates were assessed.

RESULTS: Globally, 291.2 million (11.2%) of the 2.6 billion children and adolescents (95% UI: 249.9–335.4 million) were estimated to have 1 of the 4 specified disabilities in 2017. The prevalence of these disabilities increased with age from 6.1% among children aged <1 year to 13.9% among adolescents aged 15 to 19 years. A total of 275.2 million (94.5%) lived in low- and middle-income countries, predominantly in South Asia and sub-Saharan Africa. The top 10 countries accounted for 62.3% of all children and adolescents with disabilities. These disabilities accounted for 28.9 million YLD or 19.9% of the overall 145.3 million (95% UI: 106.9–189.7) YLD from all causes among children and adolescents.

CONCLUSIONS: The number of children and adolescents with these 4 disabilities is far higher than the 2004 estimate, increases from infancy to adolescence, and accounts for a substantial proportion of all-cause YLD.

  • Abbreviations:
    GBD —
    Global Burden of Disease Study
    ICD-9 —
    International Classification of Disease, Ninth Revision
    ICD-10 —
    International Classification of Disease, 10th Revision
    ICF —
    International Classification of Functioning, Disability, and Health
    LMIC —
    low- and middle-income countries
    SDG —
    sustainable development goal
    UI —
    uncertainty interval
    WHO —
    World Health Organization
    YLD —
    years lived with disability
  • What’s Known on This Subject:

    The World Disability Report 2011 indicated that at least 93 million (∼5.1%) children <15 years old had a moderate-to-severe disability and 13 million (0.7%) had a severe disability on the basis of the Global Burden of Disease Study 2004.

    What This Study Adds:

    More than 291 million children aged <20 years had epilepsy and intellectual and sensory disabilities in 2017. The top 10 countries accounted for 62% of the children with these disabilities, and 95% lived in low and middle income countries.

    The United Nations’ Sustainable Development Goals (SDGs) mandate programs that will ensure inclusive and equitable quality education and promote lifelong learning opportunities for all children and adolescents, including those with disabilities.1 The majority of children with disabilities live in low- and middle-income countries (LMICs)2,3 and are less likely to go to school, or if they do attend school, they are more likely to leave school before completing primary or secondary education, resulting in considerable barriers to work and gainful employment.4–6 They are frequently marginalized in society and are disproportionately vulnerable to neglect, abuse, poverty, and violence.4 Thus, children and adolescents with disabilities are prone to be left behind under the SDGs era without timely and appropriate intervention from early childhood.4,5

    Limited global data exist on children and adolescents with disabilities because of insufficient investment in collecting comparable data on different disabilities.6,7 The global prevalence estimates that are most frequently cited by multilateral agencies, such as the World Health Organization (WHO),3,7 the United Nations Children’s Fund,2 the United Nations Educational, Scientific and Cultural Organization,6 the Office of the United Nations High Commissioner for Refugees,8 the World Bank Group,5 and, more recently, the US Agency for International Development,9 were first published in 2008 on the basis of the WHO’s Global Burden of Disease Study (GBD) 2004.10 The GBD estimated that in 2004, at least 93 million children and adolescents (0–15 years) worldwide (5.1% of the global total) lived with a moderate-to-severe disability, and 13 million (0.7%) had a severe disability.10 These estimates were generated from 4 specific impairments that were modeled as sequelae of specific health disorders: epilepsy, intellectual disability, hearing loss, and vision loss. However, the reported estimates excluded children and adolescents with mild impairments and were based on limited data sources. Additionally, the proportion of preschool-aged children with disabilities, who may be the most likely to benefit from early childhood intervention services, was not reported.

    Updated and improved estimates of children and adolescents with disabilities are needed to better quantify the disease burden and the resources required to address the needs and rights of these children as mandated by the SDGs,1,11 the Convention on the Rights of the Child,12 the Convention on the Rights of Persons with Disabilities,13 and the subsisting resolution of the World Health Assembly on Disability14 and in line with the International Classification of Functioning, Disability, and Health (ICF).15 Such data are also needed to monitor progress under the SDG era. We, therefore, set out to report the prevalence of childhood epilepsy, intellectual disability, vision loss, or hearing loss among children and adolescents (<20 years) and the associated years lived with disability (YLD) on the basis of data from the GBD 201716,17 to complement and update our earlier report for children <5 years of age from the GBD 2016.18

    Methods

    The GBD provides estimates of non-fatal outcomes for “impairments” (used interchangeably with “disabilities” in the current article), as part of the annual comprehensive assessment of incidence, prevalence, and YLD for several health conditions across 195 countries and territories. Impairments are defined as sequelae of multiple causes for which better data are available to estimate the overall occurrence than for each underlying cause. Four such impairments are developmental intellectual disability, epilepsy, hearing loss, and vision loss. Case definitions and diagnostic criteria for these impairments were based on International Classification of Diseases, Ninth Revision (ICD-9) and International Classification of Diseases, 10th Revision (ICD-10) codes, complemented with relevant guidelines such as the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition19 and the Guidelines for Epidemiologic Studies on Epilepsy.20 A detailed description of the GBD conceptual framework for epilepsy is reported elsewhere.21 Disorders of intellectual development in the ICD-9 and ICD-10 codes are termed as “developmental intellectual disability” or simply “intellectual disability” in this article and were grouped into 5 bands on the basis of IQ scores: borderline, mild, moderate, severe, and profound intellectual disability. Hearing and visual impairments were similarly classified into bands of severity corresponding to frequency response and visual acuity cutoffs, respectively. These 4 disabilities were selected for comparability with the GBD 2004 estimates for childhood disabilities.

    The detailed methodologic techniques used for estimating the burden of each impairment have been reported previously16–18 and are presented in the Supplemental Information. In brief, the estimation for each condition started with the compilation of all available data inputs from systematic reviews of the literature, hospital and claims databases, health surveys, case notification systems, cohort studies, and multinational survey data. All input data for GBD 2017 are available at the Global Health Data Exchange (http://ghdx.healthdata.org/gbd-2017/data-input-sources). A total of 1675 sources were analyzed for data on the prevalence of intellectual disability (57), hearing loss (355), epilepsy (455), and vision loss (808). Efforts were made to (1) optimize the comparability of data derived from various sources by using different methods, (2) find a consistent set of estimates across prevalence data, and (3) generate estimates for locations with sparse or no data by using available information from other locations combined with covariates. Prevalence estimates were produced by using DisMod-MR 2.1, a statistical modeling technique developed for the GBD project (Supplemental Fig 5).22 This is a Bayesian meta-regression tool that synthesizes epidemiological data for fatal and non-fatal health outcomes from disparate settings and sources, adjusting for different case definitions, diagnostic criteria, or sampling methods, to generate internally consistent estimates by geographical location, year, age group, and sex. The validity of DisMod has been widely reported.16–18,22

    YLD, defined as the years of life lived with a condition in a less than ideal health state, are designed to provide a comparable measure of disease burden across diverse health conditions and impairments rather than a measure of functional status, as described in ICF.15 To calculate YLD for the 4 disabilities, the estimated prevalence of each disability was multiplied by an assigned disability weight. Disability weights are the population assessment of magnitude of health loss from specific health outcomes measured on a scale from 0 to 1, in which 0 equals a state of perfect health and 1 equals death. The disability weights were estimated from multicountry population-based surveys, as described in detail elsewhere.18,23

    The global estimates of the prevalence and YLD for the 4 disabilities in children and adolescents were disaggregated by age group (children: <1, 1–4, 5–9 years; adolescents: 10–14 and 15–19 years), sex, and geographical regions (high-income North America, Western Europe, Central and Eastern Europe and Central Asia, Latin America and the Caribbean, Southeast and East Asia and Oceania, South Asia, Sub-Saharan Africa, and North Africa and the Middle East). The selected locations are not geopolitical units, but groupings of countries created by GBD for analytical purposes. All computations in the GBD were conducted 1000 times to propagate uncertainty around the estimates for prevalence and YLD. At every step in the modeling process, the distributions were assessed for the sampling error of data inputs, the uncertainty of data corrections for measurement errors, the uncertainty in coefficients from model fit, and the uncertainty of severity distributions and disability weights. The corresponding uncertainty intervals (UIs) for prevalence and YLD estimates of the 4 disabilities were defined at the 2.5th and 97.5th value of 1000 draws. As with all GBD articles, the substantive data that formed the basis of this analysis16,17 adhered to the Guidelines for Accurate and Transparent Health Estimates Reporting, which include recommendations on the documentation of data sources, estimation methods, statistical analysis, and statistical code.24

    Results

    Globally, the population of children and adolescents was ∼2.6 billion in 2017, of whom 291.2 million (95% UI: 249.9–335.4), or 11.2% (95% UI: 10.0–12.5), were estimated to have 1 of the 4 disabilities examined (Tables 1–4). Approximately 152.3 million (52.3%) were male, although the sex pattern varied across the disabilities. The prevalence of these disabilities increased with age, from 6.1% among all the ∼138 million children aged <1 year to 13.9% among the roughly 616 million adolescents aged 15 to 19 years. A total of 16 million (95% UI: 13.4–18.9 [5.5%]) lived in high-income countries, and 275.2 million (95% UI: 236.4–316.5 [94.5%]) lived in LMIC. Of all the children and adolescents with disabilities, 8.4 million (2.9%) were aged <1 year, 47.9 million (16.4%) were aged 1 to 4 years, 73.5 million (25.2%) were aged 5 to 9 years, 75.9 million (26.1%) were aged 10 to 14 years, and 85.6 million (29.4%) were aged 15 to 19 years. Thus, a total of 205.6 million (70.6%) were <15 years of age. These 4 disabilities accounted for 28.9 million YLD (or 19.9%) of the overall 145.3 million (95% UI: 106.9–189.7) YLD among children and adolescents from all causes of fatal and non-fatal outcomes included in the GBD 2017.

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    TABLE 1

    Global and Regional Age-Specific Prevalence of and YLD for Epilepsy in 2017

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    TABLE 2

    Global and Regional Age-Specific Prevalence of and YLD for Intellectual Disability in 2017

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    TABLE 3

    Global and Regional Age-Specific Prevalence of and YLD for Hearing Loss in 2017

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    TABLE 4

    Global and Regional Age-Specific Prevalence of and YLD for Vision Loss in 2017

    The prevalence of hearing loss rose from 0.9% among children aged <1 year to 5.9% (95% UI: 5.4%–6.5%) among adolescents aged 15 to 19 years (Fig 1). Vision loss rose from 1.1% among children aged <1 year to 3.9% (95% UI: 3.4%–4.6%) among adolescents aged 15 to 19 years. The prevalence of intellectual disability and epilepsy remained largely constant at ∼3% and 0.9%, respectively, in all age groups. Among all children and adolescents, the disability-specific prevalence was 0.9% (95% UI: 0.8%–1.1%) for epilepsy, 3.2% (95% UI: 2.5%–3.9%) for intellectual disability, 3.1% (95% UI: 2.7%–3.6%) for vision loss, and 4.0% (95% UI: 3.7%–4.3%) for hearing loss. However, epilepsy and intellectual disability were associated with the highest YLD in all age groups, which were significantly higher than sensory disabilities.

    FIGURE 1
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    FIGURE 1

    Global age-specific prevalence of and YLD for childhood epilepsy, intellectual disability, hearing loss and vision loss in 2017.

    South Asia accounted for the highest prevalence of intellectual disability (6.0% [95% UI: 4.5%–7.5%]), hearing loss (4.7% [95% UI: 4.3%–5.0%]), and vision loss (3.7% [95% UI: 3.2%–4.2%]), whereas Latin America and the Caribbean recorded the highest prevalence of epilepsy (1.2% [95% UI: 1.0%–1.5%]), as shown in Fig 2. Epilepsy was least prevalent in Southeast and East Asia and Oceania (0.7% [95% UI: 0.6%–0.8%]), and intellectual disability was least prevalent in Latin America and the Caribbean (1.6% [95% UI: 1.3%–1.9%]), whereas vision loss (1.2% [95% UI: 1.0%–1.5%]) and hearing loss (2.2% [95% UI: 2.1%–2.4%] were least prevalent in high-income North America. South Asia (0.6% [95% UI: 0.4%–0.7%]) and Latin America and the Caribbean (0.5% [95% UI: 0.4%–0.7%]) were associated with the highest YLD rates for intellectual disability and epilepsy, respectively. South Asia (107.8 million or 37.5%) and sub-Saharan Africa (59.8 million or 20.5%) accounted for more than half of all children and adolescents with disabilities (Fig 3). High-income North America (5.6 million or 1.9%) and Western Europe (6.2 million or 2.1%) accounted for the lowest population of children and adolescents with disabilities.

    FIGURE 2
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    FIGURE 2

    Regional prevalence of and YLD for childhood epilepsy, intellectual disability, hearing loss and vision loss in 2017.

    FIGURE 3
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    FIGURE 3

    Regional ranking of childhood epilepsy, intellectual disability, hearing loss, and vision loss by severity among children and adolescents based on estimates of prevalence and YLD in 2017. Colors correspond to the ranking of disability by severity, with dark red indicating the most common disability and dark green indicating the least common disability for the location indicated. The numbers inside each box indicate the ranking.

    Globally, mild intellectual disability (IQ scores of 50–69) was the most prevalent disability, and mild vision loss was the least prevalent disability among the 4 types of disability (Fig 3). Within regions, mild hearing loss was the most common disability in all regions except Central and Eastern Europe and Central Asia and Southeast and East Asia and Oceania. Mild vision loss was the least prevalent disability in all regions. Severe epilepsy and severe intellectual disability were the 2 most common disabilities with the highest YLD globally and in all regions. The burden of epilepsy was more concentrated in Mexico, Colombia, and Venezuela in Latin America and was more concentrated in Gabon, the Republic of the Congo, and Angola in sub-Saharan Africa (Fig 4). Intellectual disability had the highest prevalence in India (South Asia), Afghanistan, and Yemen (Middle East). Hearing loss was most prevalent in Madagascar (sub-Saharan Africa) and Myanmar (Southeast Asia), whereas vision loss was more widespread and had the highest prevalence in South Sudan, the Central African Republic (sub-Saharan Africa), and Papua New Guinea (Oceania).

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    FIGURE 4

    Global distribution of childhood epilepsy, intellectual disability, hearing loss and vision loss in 2017. A, Epilepsy, both sexes, <20 years, 2017, prevalent cases per 100 000. B, Developmental intellectual disability, both sexes, <20 years, 2017, prevalent cases per 100 000. C, Hearing loss, both sexes, <20 years, 2017, prevalent cases per 100 000. D, Blindness and vision impairment, both sexes, <20 years, 2017, prevalent cases per 100 000.

    The top 10 countries accounted for 52.8% of all children and adolescents with epilepsy, 68.0% of children and adolescents with intellectual disability, 62.0% of children and adolescents with hearing loss, and 59.4% of children and adolescents with vision loss (Supplemental Fig 6). The top 10 countries accounted for 62.3% of all children and adolescents with these disabilities. These countries also accounted for at least 53.5% of the YLD associated with these conditions. India and China had the highest population of children and adolescents with any disability, with their associated YLD. The United States was the only high-income country among the top 10 countries for any disability. However, in terms of the highest prevalence and YLD rates per population, countries with the highest prevalence were Gabon for epilepsy, India for intellectual disability, Madagascar for hearing loss, and Israel for vision loss. The underlying causes or risk factors and their ICD-9 and ICD-10 codes that formed the basis of the reported estimates for all disabilities in the GBD 2017, as well as their contributions to the aggregate estimate for each disability, are summarized in Supplemental Fig 7.

    Discussion

    Our primary aim was to update the global estimate of children and adolescents with disabilities previously attributed to the GBD 2004 and still widely reported in the literature.2–9 Although, in our study, we did not capture the full spectrum of all possible childhood disabilities, our analysis reveals that the number of children and adolescents with disabilities is at least 291 million globally and that the prevalence increases with age. Among children and adolescents <15 years, the estimate of children and adolescents with these 4 disabilities is more than twice the 2004 estimate of 93 million. The substantially higher estimate can be attributed to several factors besides the modest impact of the ∼6.6% and 4.1% rise in the global population of children and adolescents <15 and <20 years, respectively, between 2004 and 2017.25 Firstly, the number and variety of data sources used in generating estimates have increased substantially since 2004. Secondly, the modeling techniques have improved significantly on the basis of expert contributions from an increasing number of institutional and individual collaborators from 146 countries.26 Thirdly, consistent with the classification recommended by the ICF, the GBD 2017 estimates include disabilities of varying degrees of severity from slight or mild to profound for each disability. Lastly, there is now an internationally agreed on framework for evaluating estimates of health from statistical modeling, which has been strictly followed by the GBD since 2015.24

    The GBD modeling efforts are meant to bridge a critical gap in the epidemiology of developmental disorders resulting from several conceptual and operational challenges in measuring disabilities in children and adolescents.27,28 As with most health conditions, the dearth of population-based data for specific disabilities, especially in LMIC, has compelled a growing reliance on the statistical estimation of health outcomes as an interim step to guide health policy and intervention. The implicit philosophy underpinning these efforts is that the absence of conventional epidemiological data is not evidence of the absence of a health condition. Thus, GBD is an essential, independent, and up-to-date source of alternative data for policy-makers and decision-makers in global health, especially for countries with poor or no data.2,3

    However, it is helpful to evaluate the plausibility of the GBD estimates in the absence of comparable global estimates from other reputable sources. The global estimate of 0.9% (95% UI: 0.8%–1.1%) for epilepsy among all children and adolescents appears plausible on the basis of evidence in the literature, suggesting a global prevalence of between 0.5% and 1%.29,30 In addition, the estimate of 1.0% (95% UI: 0.8%–1.3%) for sub-Saharan Africa is consistent with the 0.9% reported in the most comprehensive systematic review on epilepsy to date from this region.31 The GBD estimate for intellectual disability of 3.2% (95% UI: 2.5%–3.9%) was higher than the estimate of 1.8% reported in 1 meta-analysis of population-based studies, possibly because of the inclusion of children and adolescents with comorbid autism spectrum disorder and cerebral palsy secondary to neonatal encephalopathy in the GBD.32,33 South Asia substantially contributed to the reported global estimates for intellectual disability, and the age-specific GBD estimates for this region are supported by a recent robust population-based study from India in which a prevalence of 5.2% was reported.34 Sensory disabilities are perhaps the most researched childhood disabilities worldwide. Several studies in school-aged children support the reported estimates for vision loss and hearing loss, with most suggesting that the GBD estimates were conservative.35–38 For example, in 1 systematic review of childhood hearing loss, a prevalence of between 0.8% and 46.7% was reported across 26 well-conducted studies from different regions,36 whereas 2 population-based studies from Canada and the United Sates revealed estimates of between 4.5% and 7.9%, compared with a GBD estimate of 2.2% for North America. More crucially, these findings underscore the need to develop local capacity toward early identification and timely on-going support for children and adolescents with any disability and their families, especially in high-burden LMIC. The unique challenges faced by children with disabilities as they transition into adolescence also need to be recognized and addressed.39

    This study has several limitations worth emphasizing. Most importantly, our main finding must be regarded as a conservative estimate of children with disabilities in general because this study was restricted to 4 conditions. The inclusion of conditions such as cerebral palsy without comorbid intellectual disability would have increased the reported estimates in our article. Additionally, the GBD 2017 has methodologic limitations that have been extensively described in previous publications in accordance with the Guidelines for Accurate and Transparent Health Estimates Reporting.16–18 For example, the 95% UIs around estimates for regions with sparse data are still wide. Most of the uncertainty in the YLD estimates results from the current limitations in the determination of disability weights that may be minimized in the future by removing some of the ambiguities in lay descriptions and increasing the volume of survey data. In addition, despite the continuous efforts toward improving the GBD methodology, concerns remain on estimating the prevalence of disabilities solely as sequelae of health conditions.2,3,40 Furthermore, the estimates do not fully reflect the complex and dynamic relationship between health conditions and contextual personal or environmental factors, as envisaged under the ICF, and so provide a limited picture of disability.15 Finally, it was difficult to completely and precisely account for children with multiple disabilities and across multiple developmental domains. These considerations reveal the need for complementary nationally representative disability data, such as those published periodically by the United Nations Children’s Fund and the WHO, that can be used as additional data inputs for the GBD. Although estimates of disabilities from both statistical modeling and household surveys are not definitive, they reflect current knowledge and the best available evidence to inform policies and interventions.

    Conclusions

    In the most recent GBD, it is shown that the number of children and adolescents with disabilities globally far exceeds the estimate in 2004. The burden of disability is substantial from early childhood and corroborates our earlier report on the need to address the quality of life of many beneficiaries of the child survival programs during the era of the Millennium Development Goals (2000–2015).18 The risk likely to be faced by the affected children and adolescents of not realizing their full potential, especially in LMIC, as envisaged under the SDGs era, is real and disturbing. Regardless of the inherent limitations of modeled estimates, the findings from our analysis are plausible and insightful. These findings shed light on the high and growing health needs among child survivors that warrant significant investments and should be a wake-up call to public health leaders and advocates globally. A committed global leadership will ensure that these and other vulnerable children and adolescents are truly not left behind in accordance with the obligations under the Convention on the Rights of the Child and the Convention on the Rights of Persons with Disabilities.

    Acknowledgments

    We thank Christopher J.L. Murray, Theo Vos, and Mohsen Naghavi of the Institute for Health Metrics and Evaluation for their overall guidance of the substantive GBD study that formed the basis of this analysis.

    Footnotes

      • Accepted April 8, 2020.
    • Address correspondence to Bolajoko O. Olusanya, FRCPCH, PhD, Center for Healthy Start Initiative, 286A Corporation Dr, Dolphin Estate, Ikoyi, Lagos, Nigeria. E-mail: bolajoko.olusanya{at}uclmail.net
    • Dr Abubakar's current affliation is Institute for Human Development, Aga Khan University, Nairobi, Kenya.

    • FINANCIAL DISCLOSURE: Dr Kassebaum reports personal fees and nonfinancial support from Vifor Pharma Group outside the submitted work; the other authors have indicated they have no financial relationships relevant to this article to disclose.

    • FUNDING: No external funding was received by any of the authors for this work. The substantive data that formed the basis of this article and the open access charge were funded by the Bill & Melinda Gates Foundation. This article is licensed under the Creative Commons Attribution 4.0 International License. The named authors alone are responsible for the views expressed in this publication.

    • POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

    References

    1. ↵
      United Nations. Sustainable Development Goals. New York, NY: United Nations; 2015. Available at: www.un.org/sustainabledevelopment/sustainable-development-goals/. Accessed July 30, 2019
    2. ↵
      United Nations Children’s Fund. The State of the World’s Children 2013: Children With Disabilities. New York, NY: United Nations Children’s Fund; 2013. Available at: https://www.unicef.org/sowc2013/files/SWCR2013_ENG_Lo_res_24_Apr_2013.pdf. Accessed July 30, 2019
    3. ↵
      World Health Organization; The World Bank. World Report on Disability. Geneva, Switzerland: World Health Organization; 2011. Available at: www.who.int/disabilities/world_report/2011/report.pdf. Accessed July 30, 2019
    4. ↵
      United Nations Educational, Scientific and Cultural Organization. Education and disability. Available at: http://uis.unesco.org/sites/default/files/documents/fs40-education-and-disability-2017-en.pdf. Accessed July 30, 2019
    5. ↵
      1. Male C,
      2. Wodon Q
      . The Price of Exclusion: Disability and Education: Disability Gaps in Educational Attainment and Literacy. Washington, DC: The World Bank; 2017. Available at: http://documents.worldbank.org/curated/en/396291511988894028/pdf/121762-replacement-PUBLIC-WorldBank-GapsInEdAttainmentLiteracy-Brief-v6.pdf. Accessed July 30, 2019
    6. ↵
      United Nations Educational, Scientific and Cultural Organization. GEM report summary on disabilities and education. Available at: https://en.unesco.org/gem-report/sites/gem-report/files/GAW2014-Facts-Figures-gmr_0.pdf.pdf. Accessed July 30, 2019
    7. ↵
      1. World Health Organization
      . WHO Global Disability Action Plan 2014–2021: Better Health for All People With Disability. Geneva, Switzerland: World Health Organization; 2015. Available at: https://www.who.int/disabilities/actionplan/en/. Accessed July 30, 2019
    8. ↵
      United Nations High Commission for Human Rights. 93 million children with disabilities ‘among the most likely to be left behind’: UN rights chief. Available at: https://news.un.org/en/story/2019/03/1034011. Accessed July 30, 2019
    9. ↵
      1. US Agency for International Development
      . Advancing protection and care for children in adversity: a US Government strategy for international assistance (2019–2023). Available at: https://www.usaid.gov/documents/1866/advancing-protection-and-care-children-adversity. Accessed July 30, 2019
    10. ↵
      World Health Organization. The Global Burden of Disease: 2004 Update. Geneva, Switzerland: World Health Organization; 2008. Available at: www.who.int/iris/handle/10665/43942. Accessed July 30, 2019
    11. ↵
      1. Olusanya BO,
      2. Krishnamurthy V,
      3. Wertlieb D
      . RE: global initiatives for early childhood development should be disability inclusive. Pediatrics. 2018;141(3):e20174055
      OpenUrlFREE Full Text
    12. ↵
      1. United Nations Convention on the Rights of the Child
      . 1990. UNCRC 1990. Available at: https://www.unicef.org.uk/what-we-do/un-convention-child-rights/. Accessed July 30, 2019
    13. ↵
      Convention on the Rights of Persons with Disabilities (CRPD) 2006. CRPD 2006. Available at: https://www.un.org/disabilities/documents/convention/convoptprot-e.pdf. Accessed July 30, 2019
    14. ↵
      World Health Organization. Disability. In: 66th World Health Assembly; May 20–27, 2013; Geneva, Switzerland
    15. ↵
      1. World Health Organization
      . International Classification of Functioning, Disability and Health. Geneva, Switzerland: World Health Organization; 2001
    16. ↵
      1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators
      . Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 [published correction appears in Lancet. 2019;393(10190):e44]. Lancet. 2018;392(10159):1789–1858
      OpenUrlCrossRefPubMed
    17. ↵
      1. Reiner RC Jr.,
      2. Olsen HE,
      3. Ikeda CT, et al; GBD 2017 Child and Adolescent Health Collaborators
      . Diseases, injuries, and risk factors in child and adolescent health, 1990 to 2017: findings from the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study. JAMA Pediatr. 2019;173(6):e190337
      OpenUrl
    18. ↵
      1. Global Research on Developmental Disabilities Collaborators
      . Developmental disabilities among children younger than 5 years in 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 [published correction appears in Lancet Glob Health. 2018;6(12):e1287]. Lancet Glob Health. 2018;6(10):e1100–e1121
      OpenUrl
    19. ↵
      1. American Psychiatric Association
      . Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR), 4th ed, Text Revision. Washington, DC: American Psychiatric Association; 2000
    20. ↵
      1. Thurman DJ,
      2. Beghi E,
      3. Begley CE, et al; ILAE Commission on Epidemiology
      . Standards for epidemiologic studies and surveillance of epilepsy. Epilepsia. 2011;52(suppl 7):2–26
      OpenUrlCrossRefPubMed
    21. ↵
      1. GBD 2016 Epilepsy Collaborators
      . Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 [published correction appears in Lancet Neurol. 2019;18(5):e4]. Lancet Neurol. 2019;18(4):357–375
      OpenUrl
    22. ↵
      1. Flaxman AD,
      2. Vos T,
      3. Murray CJL, eds
      . An Integrative Metaregression Framework for Descriptive Epidemiology, 1st ed. Seattle, WA: University of Washington Press; 2015
    23. ↵
      1. Salomon JA,
      2. Haagsma JA,
      3. Davis A, et al
      . Disability weights for the Global Burden of Disease 2013 study. Lancet Glob Health. 2015;3(11):e712–e723
      OpenUrl
    24. ↵
      1. Stevens GA,
      2. Alkema L,
      3. Black RE, et al; GATHER Working Group
      . Guidelines for accurate and transparent health estimates reporting: the GATHER statement [published correction appears in PLoS Med. 2016;13(8):e1002116]. PLoS Med. 2016;13(6):e1002056
      OpenUrlPubMed
    25. ↵
      1. United Nations Population Division
      . United Nations World Population Prospects 1950–2100 - 2010 Revision. New York, NY: United Nations; 2011
    26. ↵
      1. Murray CJL,
      2. Lopez AD
      . Measuring global health: motivation and evolution of the Global Burden of Disease Study. Lancet. 2017;390(10100):1460–1464
      OpenUrlPubMed
    27. ↵
      1. Loeb M,
      2. Mont D,
      3. Cappa C,
      4. De Palma E,
      5. Madans J,
      6. Crialesi R
      . The development and testing of a module on child functioning for identifying children with disabilities on surveys. I: background. Disabil Health J. 2018;11(4):495–501
      OpenUrl
    28. ↵
      1. Gladstone M,
      2. Abubakar A,
      3. Idro R,
      4. Langfitt J,
      5. Newton CR
      . Measuring neurodevelopment in low-resource settings. Lancet Child Adolesc Health. 2017;1(4):258–259
      OpenUrl
    29. ↵
      1. Aaberg KM,
      2. Gunnes N,
      3. Bakken IJ, et al
      . Incidence and prevalence of childhood epilepsy: a nationwide cohort study. Pediatrics. 2017;139(5):e20163908
      OpenUrlAbstract/FREE Full Text
    30. ↵
      1. Camfield P,
      2. Camfield C
      . Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord. 2015;17(2):117–123
      OpenUrlPubMed
    31. ↵
      1. Ba-Diop A,
      2. Marin B,
      3. Druet-Cabanac M,
      4. Ngoungou EB,
      5. Newton CR,
      6. Preux PM
      . Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa. Lancet Neurol. 2014;13(10):1029–1044
      OpenUrl
    32. ↵
      1. Maulik PK,
      2. Mascarenhas MN,
      3. Mathers CD,
      4. Dua T,
      5. Saxena S
      . Prevalence of intellectual disability: a meta-analysis of population-based studies [published correction appears in Res Dev Disabil. 2013;34(2):729]. Res Dev Disabil. 2011;32(2):419–436
      OpenUrlCrossRefPubMed
    33. ↵
      1. McKenzie K,
      2. Milton M,
      3. Smith G, et al.
      H. Systematic review of the prevalence and incidence of intellectual disabilities: current trends and issues. Curr Dev Disord Rep. 2016;3:104–115
      OpenUrlCrossRef
    34. ↵
      1. Arora NK,
      2. Nair MKC,
      3. Gulati S, et al
      . Neurodevelopmental disorders in children aged 2-9 years: population-based burden estimates across five regions in India. PLoS Med. 2018;15(7):e1002615
      OpenUrl
    35. ↵
      1. Reddy PA,
      2. Bassett K
      . Visual acuity screening in schools: a systematic review of alternate screening methods. Cogent Med. 2017;4(1):1371103
      OpenUrl
    36. ↵
      1. Nunes ADDS,
      2. Silva CRL,
      3. Balen SA,
      4. Souza DLB,
      5. Barbosa IR
      . Prevalence of hearing impairment and associated factors in school-aged children and adolescents: a systematic review. Braz J Otorhinolaryngol. 2019;85(2):244–253
      OpenUrl
      1. Feder KP,
      2. Michaud D,
      3. McNamee J,
      4. Fitzpatrick E,
      5. Ramage-Morin P,
      6. Beauregard Y
      . Prevalence of hearing loss among a representative sample of Canadian children and adolescents, 3 to 19 years of age. Ear Hear. 2017;38(1):7–20
      OpenUrl
    37. ↵
      1. Hoffman HJ,
      2. Dobie RA,
      3. Losonczy KG,
      4. Themann CL,
      5. Flamme GA
      . Kids nowadays hear better than we did: declining prevalence of hearing loss in US youth, 1966-2010. Laryngoscope. 2019;129(8):1922–1939
      OpenUrl
    38. ↵
      1. National Academies of Sciences Engineering and Medicine
      2. Health and Medicine Division
      3. Board on Health Care Services
      4. Committee on Improving Health Outcomes for Children with Disabilities
      . In: Byers E, Valliere FR, Houtrow AJ, eds. Opportunities for Improving Programs and Services for Children With Disabilities. Washington, DC: National Academies Press; 2018
    39. ↵
      1. Graham N,
      2. Schultz L,
      3. Mitra S,
      4. Mont D
      . Disability in Middle Childhood and Adolescence. In: Bundy DAP, Silva N, Horton S, Jamison DT, Patton GC, eds. Child and Adolescent Health and Development, 3rd ed. Washington, DC: The International Bank for Reconstruction and Development/The World Bank; 2017:221–237
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    Global Burden of Childhood Epilepsy, Intellectual Disability, and Sensory Impairments
    Bolajoko O. Olusanya, Scott M. Wright, M.K.C. Nair, Nem-Yun Boo, Ricardo Halpern, Hannah Kuper, Amina A. Abubakar, Nihad A. Almasri, Jalal Arabloo, Narendra K. Arora, Sophia Backhaus, Brad D. Berman, Cecilia Breinbauer, Gwen Carr, Petrus J. de Vries, Christie del Castillo-Hegyi, Aziz Eftekhari, Melissa J. Gladstone, Rosa A. Hoekstra, Vijaya Kancherla, Mphelekedzeni C. Mulaudzi, Angelina Kakooza-Mwesige, Felix A. Ogbo, Helen E. Olsen, Jacob O. Olusanya, Ashok Pandey, Maureen E. Samms-Vaughan, Chiara Servili, Amira Shaheen, Tracey Smythe, Donald Wertlieb, Andrew N. Williams, Charles R.J. Newton, Adrian C. Davis, Nicholas J. Kassebaum, on behalf of the Global Research on Developmental Disabilities Collaborators (GRDDC)
    Pediatrics Jul 2020, 146 (1) e20192623; DOI: 10.1542/peds.2019-2623

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    Global Burden of Childhood Epilepsy, Intellectual Disability, and Sensory Impairments
    Bolajoko O. Olusanya, Scott M. Wright, M.K.C. Nair, Nem-Yun Boo, Ricardo Halpern, Hannah Kuper, Amina A. Abubakar, Nihad A. Almasri, Jalal Arabloo, Narendra K. Arora, Sophia Backhaus, Brad D. Berman, Cecilia Breinbauer, Gwen Carr, Petrus J. de Vries, Christie del Castillo-Hegyi, Aziz Eftekhari, Melissa J. Gladstone, Rosa A. Hoekstra, Vijaya Kancherla, Mphelekedzeni C. Mulaudzi, Angelina Kakooza-Mwesige, Felix A. Ogbo, Helen E. Olsen, Jacob O. Olusanya, Ashok Pandey, Maureen E. Samms-Vaughan, Chiara Servili, Amira Shaheen, Tracey Smythe, Donald Wertlieb, Andrew N. Williams, Charles R.J. Newton, Adrian C. Davis, Nicholas J. Kassebaum, on behalf of the Global Research on Developmental Disabilities Collaborators (GRDDC)
    Pediatrics Jul 2020, 146 (1) e20192623; DOI: 10.1542/peds.2019-2623
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