PURPOSE OF THE STUDY.
To assess the accuracy and the negative predictive value of the provocation challenge in a cohort of children referred to a single center with suspected amoxicillin allergy.
Children with suspected amoxicillin allergy who were referred to the Montreal Children’s Hospital in Quebec, Canada, between March 1, 2012, and April 1, 2015, were recruited. Exclusion criteria were any reactions compatible with either Stevens-Johnson syndrome or toxic epidermal necrolysis.
Children with a prior history of rash while receiving …