PURPOSE OF STUDY.
To investigate the association between serum eosinophil levels and the development of atopic dermatitis (AD) in a birth cohort of patients at risk for atopic disease.
This study included pediatric patients from a German randomized placebo-controlled trial for primary prevention of AD by using Pro-Symbioflor, an oral bacterial lysate treatment (ISRCTN60475069), conducted between 2002 and 2007.
Study participants were randomly assigned to receive either Pro-Symbioflor or placebo, from 5 weeks until 7 months of age. Blood samples were collected at 4 weeks (preintervention) and 7 months of age (postintervention) and were used to measure blood eosinophil counts. The infants were evaluated by trained pediatricians for the …