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American Academy of Pediatrics
Article

Liquid Medication Errors and Dosing Tools: A Randomized Controlled Experiment

H. Shonna Yin, Ruth M. Parker, Lee M. Sanders, Benard P. Dreyer, Alan L. Mendelsohn, Stacy Bailey, Deesha A. Patel, Jessica J. Jimenez, Kwang-Youn A. Kim, Kara Jacobson, Laurie Hedlund, Michelle C. J. Smith, Leslie Maness Harris, Terri McFadden and Michael S. Wolf
Pediatrics October 2016, 138 (4) e20160357; DOI: https://doi.org/10.1542/peds.2016-0357
H. Shonna Yin
aDepartment of Pediatrics, NYU School of Medicine–Bellevue Hospital, New York, New York;
bDepartment of Population Health, NYU School of Medicine, New York, New York;
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Ruth M. Parker
cDepartment of Medicine,
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Lee M. Sanders
dDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, California;
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Benard P. Dreyer
aDepartment of Pediatrics, NYU School of Medicine–Bellevue Hospital, New York, New York;
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Alan L. Mendelsohn
aDepartment of Pediatrics, NYU School of Medicine–Bellevue Hospital, New York, New York;
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Stacy Bailey
eDivision of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, Chapel Hill, North Carolina;
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Deesha A. Patel
fDivision of General Internal Medicine and Geriatrics, and
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Jessica J. Jimenez
aDepartment of Pediatrics, NYU School of Medicine–Bellevue Hospital, New York, New York;
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Kwang-Youn A. Kim
gDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
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Kara Jacobson
hRollins School of Public Health, and
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Laurie Hedlund
fDivision of General Internal Medicine and Geriatrics, and
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Michelle C. J. Smith
dDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, California;
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Leslie Maness Harris
aDepartment of Pediatrics, NYU School of Medicine–Bellevue Hospital, New York, New York;
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Terri McFadden
iDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia;
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Michael S. Wolf
fDivision of General Internal Medicine and Geriatrics, and
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Abstract

BACKGROUND AND OBJECTIVES: Poorly designed labels and packaging are key contributors to medication errors. To identify attributes of labels and dosing tools that could be improved, we examined the extent to which dosing error rates are affected by tool characteristics (ie, type, marking complexity) and discordance between units of measurement on labels and dosing tools; along with differences by health literacy and language.

METHODS: Randomized controlled experiment in 3 urban pediatric clinics. English- or Spanish-speaking parents (n = 2110) of children ≤8 years old were randomly assigned to 1 of 5 study arms and given labels and dosing tools that varied in unit pairings. Each parent measured 9 doses of medication (3 amounts [2.5, 5, and 7.5 mL] and 3 tools [1 cup, 2 syringes (0.2- and 0.5-mL increments)]), in random order. Outcome assessed was dosing error (>20% deviation; large error defined as > 2 times the dose).

RESULTS: A total of 84.4% of parents made ≥1 dosing error (21.0% ≥1 large error). More errors were seen with cups than syringes (adjusted odds ratio = 4.6; 95% confidence interval, 4.2–5.1) across health literacy and language groups (P < .001 for interactions), especially for smaller doses. No differences in error rates were seen between the 2 syringe types. Use of a teaspoon-only label (with a milliliter and teaspoon tool) was associated with more errors than when milliliter-only labels and tools were used (adjusted odds ratio = 1.2; 95% confidence interval, 1.01–1.4).

CONCLUSIONS: Recommending oral syringes over cups, particularly for smaller doses, should be part of a comprehensive pediatric labeling and dosing strategy to reduce medication errors.

  • Abbreviations:
    AAP —
    American Academy of Pediatrics
    aOR —
    adjusted odds ratio
    CI —
    confidence interval
    FDA —
    US Food and Drug Administration
    OTC —
    over the counter
    RA —
    research assistant
  • What’s Known on This Subject:

    Despite studies showing that >40% of parents make errors dosing liquid medications, there has been limited focus to date on identifying specific attributes of pediatric labels and dosing tools that could be improved to reduce the likelihood of error.

    What This Study Adds:

    Significant reductions in dosing errors would probably result if parent oral syringe use was promoted over dosing cups, especially when smaller doses are recommended. Avoidance of teaspoon alone on medication labels may also be helpful in decreasing errors.

    Over the past decade, growing attention has been paid to the problem of unintentional medication errors resulting from suboptimal drug labeling and medication packaging.1–7 Although considerable progress has been attained in making labeling improvements for adult medications,3,8–11 to date there has been limited work incorporating a pediatric perspective, despite studies documenting parent dosing error rates of ≥40%.12–16 Lack of evidence regarding best practices has been a barrier to establishing standards related to the labeling and dosing of pediatric medications.17

    Unlike most prescription drugs taken by adults, pediatric medications are unique in their reliance on liquid formulations.18 With oral liquid medicines, parents must choose an appropriate tool with which to measure and administer medicine to their children.14 In addition, a range of measurement units (eg, milliliter, teaspoon, tablespoon), along with their associated abbreviations, are used as part of instructions on labels and dosing tools, contributing to confusion and multifold errors.7,14,19–21

    To promote dosing accuracy, both the American Academy of Pediatrics (AAP) and the US Food and Drug Administration (FDA) recommend that parents use dosing tools with standard markings (eg, oral syringes, droppers, dosing cups) rather than nonstandard kitchen spoons, which vary widely in size and shape.19,21–24 However, no national guidelines exist regarding which type of tool should be provided to families. Oral syringes are considered the gold standard when accuracy is critical.14,25–27 Cups are most frequently included with over-the-counter (OTC) products.28 Several studies have found that cups are associated with higher rates of parent errors, but they were limited in scope with respect to the range of dose amounts tested and aspects such as complexity of tool markings.14,27,29

    Unit of measurement discordance has become an issue of concern for prescription and OTC medicines.19,29 One study of top-selling OTC pediatric products found that nearly 90% had a mismatch in units between the label and dosing tool,28 before a 2009 FDA guidance for industry was issued.22 A study of prescribed products found that more than a third of the time, the label did not contain the same units as the prescription.13 Recently, the AAP issued a policy statement endorsing a move to a milliliter-exclusive system and avoidance of terms such as teaspoon and tablespoon,7 a stance consistent with that of other organizations, including the FDA and the American Academy of Family Physicians,20,30–32 but there are concerns that such a move could result in greater confusion because parents may be comfortable dosing using teaspoon and tablespoon terms and unfamiliar with milliliter units7,13; the United States has had a long-standing dependence on nonmetric units.33

    In this study, we sought to fill gaps in evidence about best practices for the labeling and dosing of pediatric liquid medications. Specifically, we examined the extent to which rates of parent dosing errors are affected by discordance in unit pairing on the label and tool and by dosing tool characteristics (ie, type, marking complexity). We hypothesized that unit concordance would be associated with fewer errors and that parents would measure most accurately with syringes. We also sought to examine differences in impact by parent health literacy and language, because low health literacy and limited English proficiency are factors known to place children at risk for error.23,34–36

    Methods

    Participants, Recruitment, and Randomization

    This was a randomized controlled experiment to examine the degree to which specific attributes of medication labels and dosing tools affect parent errors in dosing liquid medicines. As part of the SAFE Rx for Kids (Safe Administration for Every Prescription for Kids) study, subjects were enrolled from pediatric outpatient clinics at Bellevue (New York, NY), Gardner Packard Children’s Health Care Center (Stanford, CA), and Children’s Healthcare of Atlanta at Hughes Spalding (Atlanta, GA). Institutional review board approval was obtained from each site.

    During clinic hours when enrollment took place, research assistants (RAs) consecutively assessed parents and caregivers to determine eligibility. Inclusion criteria were parent or legal guardian ≥18 years old with a child ≤8 years old, presenting for nonemergency care, who was English or Spanish-speaking, usually administers medications, and had no previous participation in a medication-related study. Exclusion criteria included visual acuity worse than 20/50 (Rosenbaum), hearing impairment, and parent or child too ill to participate. Participants provided written, informed consent.

    Upon enrollment, subjects were randomly assigned to 1 of 5 groups. Groups differed by the pairing of units used on the bottle label and tool: mL–mL (group 1), mL and tsp–mL and tsp (group 2), mL and teaspoon–mL and tsp (group 3), mL–mL and tsp (group 4), and teaspoon–mL and tsp (group 5) (Fig 1A). Because a move to a milliliter-only system has been recommended by numerous organizations, group 1 was considered the gold standard scenario. Randomization was conducted via a random number generator, blocked by site, in sets of 100 (20 per group). The lead project coordinator (J.J.J.) generated the allocation sequence; RAs at each site were blinded to group until after subjects were enrolled. Once the dosing assessment was initiated, it was not possible for the RA or participant to remain blinded, because it was clear from the labels and tools being presented which group the participant had been assigned to.

    FIGURE 1
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    FIGURE 1

    Medication labels and dosing tools tested. A, Comparison of randomization group characteristics. Unit label and dosing tool pairings were chosen because they represent the most common current standard practices used to display dose amounts on medication labels and dosing tools. The combination of units on labels and dosing tools applied to 3 different dosing tools given to each person (2 oral syringes [1 0.2-mL increment and 1 0.5-mL increment] and 1 cup); each subject measured 3 doses with the 3 tools, for a total of 9 doses. aExample of group 2 medication label is shown in Fig 1B. Teaspoon units on English-language medication labels were translated into Spanish, consistent with recommended pharmacy practices. The abbreviation tsp was displayed as cdta on Spanish-language medication bottle labels, and teaspoon was displayed as cucharadita on the Spanish-language medication bottle labels. bDosing tools had units marked in English only, as is standard practice in the United States. For dosing tools, mL and tsp tools are most commonly used and were therefore included for the majority of groups. See Fig 1C. cThe milliliter-only system is endorsed by the AAP, the Centers for Disease Control and Prevention, and other national organizations. B, Example of group 2 medication label (English). C, Dosing tools tested.

    Assessments

    All assessments were performed on the day of enrollment. Interviews were conducted by trained RAs in English or Spanish (caregiver preference). Dosing assessments were conducted, followed by a survey to assess sociodemographics and health literacy. A $20 gift card incentive was provided.

    Dosing Accuracy

    Trained RAs presented each caregiver with a series of bottle labels and tools, which caregivers looked at to respond to questions and demonstrate dosing (Fig 1). Each caregiver was asked to measure 3 amounts (2.5, 5, and 7.5 mL) by using 3 tools (9 total trials). The 3 tools were 2 syringes (10-mL capacity; 1 with 0.2-mL and 1 with 0.5-mL increment markings) and 1 dosing cup (30-mL capacity). A random number generator was used to randomize the order in which caregivers were presented with each tool type and dose amount. Custom-designed tools (Comar, Buena, NJ) were used so that tools tested across groups varied only by markings.

    Caregivers were presented with the 9 sets of label and tool pairs, one at a time. Labels were in English or Spanish (caregiver preference). Caregivers were allotted as much time as they wanted to read each label and were instructed, “Please use this [DOSING TOOL HANDED TO PARENT] to show me how much medicine the label tells you to give the child each time you give the medicine.” For each trial, caregivers were given a standard medication bottle, filled to the same level; the medication used had a viscosity similar to common children’s medication suspensions.

    Dosing error was the primary outcome variable; magnitude of error was determined by an established protocol.14 The weight of the measured dose (tool weight containing parents’ measured dose minus preassessment tool weight) was compared with a reference weight (eg, for 5-mL dose, the average weight of 5 mL measured by 10 pediatricians using an oral syringe was determined). A pharmacy-grade electronic digital prescription class II scale (Torbal DRX-4; Fulcrum Inc, Clifton, NJ) was used.

    The primary criterion used to determine whether an error was made was whether the measured amount fell within 20% of the label amount.12–14,16,37 To look at errors of greater magnitude, we also performed analyses for large errors, using a cutoff point of 2 times above the tested dose.

    Sociodemographic Data, Health Literacy, and Child Health Status

    Sociodemographic data assessed included child (age, gender) and parent (age, relationship to child, income, country of birth, race or ethnicity, language, education) characteristics. Parent health literacy was assessed with the Newest Vital Sign.38 Child’s chronic disease status and medication use were assessed via questions adapted from the Children With Special Health Care Needs screener.39

    Statistical Analyses

    Statistical analyses were performed in SAS software version 9.4 (SAS Institute, Inc, Cary, NC). We used χ2, analysis of variance, and Kruskall–Wallis tests to compare parent characteristics between randomization groups. For dosing accuracy, analyses were performed to compare error rates (with cutoffs of >20% deviation and >2 times the dose) by randomization group and tool type (ie, syringe with 0.2- or 0.5-mL-increment markings, cup). Findings were analyzed by assigned group (all parents received assigned label–tool pairings). Multiple logistic regression with generalized estimating equations was used to account for repeated measures (9 trials per subject). In addition to group and tool type, covariates selected a priori for inclusion in adjusted analyses were key study variables of dose amount, dosing order, and label language. In addition, characteristics found to be statistically different between groups were included (ie, health literacy). Stratified analyses and interaction tests were performed by health literacy and by language.

    Sample Size Calculation

    We conservatively estimated a sample size of 420 patients per arm, or 2100 total subjects, based on known rates of dosing errors from previous studies, which typically range from 10% to 50% depending on the tool used.12,14,27 This sample size would allow us to detect an absolute difference of ∼10% with 80% power for our hypotheses related to unit pairings and tool type.

    Results

    Between August 26, 2013 and December 18, 2014, 2110 parents enrolled in the study and were randomly assigned to 1 of the 5 groups (Fig 2). Dosing assessments were completed for 2099 parents (Table 1).

    FIGURE 2
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    FIGURE 2

    Study enrollment flowchart. aRan out of time after signing consent.

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    TABLE 1

    Characteristics of Study Population (n = 2099)a

    Dosing Accuracy

    Nearly all parents (99.3%) measured ≥1 dose that was not the exact amount. Overall, 84.4% of parents made ≥1 dosing error (>20% deviation) in their 9 trials, with parents making errors in 25.3% of trials on average (mean [SD] number of errors = 2.3 [2.0]). Overdosing was present in 68.0% of errors. There were more errors with 2.5- and 7.5-mL dose amounts, compared with 5-mL dose amounts (2.5 vs 5 mL adjusted odds ratio [aOR] = 4.2; 95% CI, 3.8–4.6; 7.5 vs 5 mL aOR = 1.4; 95% CI, 1.2–1.5). Test order was associated with error, with a clear trend toward fewer errors as parents went through the trials. Overall, 21.0% made ≥1 large error (>2 times the dose).

    Unit of Measurement Pairing

    Group 5 was the only group that was associated with more errors than the milliliter-only group 1 (aOR = 1.2; 95% CI, 1.01–1.4) (Table 2). Similar findings were seen with large errors (aOR = 1.4; 95% CI, 0.97–1.9). No group by health literacy interaction was found, but a group by language interaction was seen (P = .006) (Table 3).

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    TABLE 2

    Dosing Error by Dosing Tool Type and Randomization Group (n = 2058)

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    TABLE 3

    Dosing Error by Dosing Tool Type and Randomization Group, Stratified by Health Literacy and Language (n = 2058)

    Dosing Tools

    There was no significant difference in error rates with syringes that had 0.2-mL vs 0.5-mL-increment markings. More errors were seen with cups than syringes (cup vs 0.5-mL-increment syringe aOR = 4.6; 95% CI, 4.2–5.1 [Table 2]); differences in error rates were greatest for 2.5- and 5-mL doses (Fig 3). For large errors (>2 times the dose), the odds of error with cups remained higher than with syringes (aOR = 3.8; 95% CI, 3.1–4.7).

    FIGURE 3
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    FIGURE 3

    Dosing errors by tool type across the 3 doses tested.

    The odds of making an error with a cup versus syringe varied by health literacy (P < .001 for interaction) (Table 3). The odds of making an error by tool type also varied by language, with cup versus syringe differences more prominently seen for English-speaking parents, although both language groups had fewer errors with syringes (P < .001 for interaction).

    Discussion

    This study is the first to rigorously examine, within an experimental study, whether altering specific label and dosing tool attributes can reduce parent liquid medication dosing error rates. Overall, we found high dosing error rates. Little variation in errors was observed by unit pairings tested, although parents who received teaspoon-only labels with milliliter and teaspoon dosing tools made significantly more errors than those receiving milliliter-only labels and tools. Use of dosing cups greatly increased the risk of errors, especially with smaller dose amounts. Although the strength of associations differed somewhat by health literacy and language, our study clearly identified certain improvements that could be made to labels and tools to enhance dosing accuracy for parents across groups.

    Overall, >80% of parents made ≥1 dosing error (>20% deviation), and >20% made ≥1 large error (>2 times the dose). Previous studies have demonstrated high error rates with liquid medications.12,13,15,16 A range of definitions for error have been used in the literature, with some relying on specific deviations in amount (eg, 0.2 mL),21 whereas others use percentage deviations (eg, 10%, 20%).16,37 We defined an error as >20% deviation, because we hoped to identify strategies that could be universally applied as part of a public health approach, recognizing that some medications have a narrow therapeutic window.15 For some medications, errors within an even smaller range (<20% deviation) may be clinically significant; additional intervention strategies may be important to reduce errors for these high-risk medications, including more intensive teaching or coaching.

    Dosing error rates varied little by the unit pairings on the label and tool we studied. Use of teaspoon only on the label when paired with an mL and tsp tool was associated with a slightly higher error rate and was the only mismatch found to differ significantly from the milliliter-only group. Even in the milliliter-only group, parents made errors in 1 of 4 trials on average. These findings suggest that additional strategies beyond moving to milliliter-exclusive dosing, as supported by a 2015 AAP Policy Statement,7 will probably be needed for the greatest reduction in parent dosing error rates. Although no statistically significant difference by health literacy was seen, there was a trend for unit mismatches being most confusing for those with lower literacy. The impact of unit mismatch also varied significantly by language. Spanish parents faced a difficult mismatch in group 5, with cucharadita shown on the label and tools with mL and tsp.

    In our study, cups were associated with >4 times the odds of error compared with syringes; similar findings were seen with large errors. Previous studies have demonstrated the superiority of syringes to cups when a 5-mL dose was tested14,27; our study is unique in that we examined a range of doses. One reason why cups may be inferior to syringes is that the same distance along the side of the tool represents a greater volume for cups than for syringes (eg, for cups, 1 mm might represent 0.8 mL; for syringes, 1 mm might represent 0.1 mL).27 In addition, when a cup is not held at eye level, it may appear to be filled to a particular marking when it is not.14 Even with syringes, however, a significant number of parents made dosing errors, suggesting that more intensive education by physicians, pharmacists, and other staff may be needed; use of strategies such as pictures or drawings, teachback, or showback, and demonstration may be beneficial.40

    Interestingly, although there was a comparable reduction in absolute risk for error of 24% to 30% across literacy and language groups, a significant percentage of low-literacy (1 in 4) and Spanish-speaking parents (1 in 5) still made errors with syringes. These findings suggest that for these at-risk populations, a policy change to replace cups with syringes will probably not be sufficient.

    We also found that the odds of error for syringes versus cups varied by dose, with tool type having the greatest impact with smaller doses. Our findings suggest that it may be beneficial to recommend the use of different tool types depending on the dose amount. The 2015 AAP policy statement on milliliter-exclusive dosing recommends provision of standardized tools with milliliter markings, preferably syringes, with cups and spoons with calibrated markings considered acceptable alternatives; no recommendations based on dose amount were provided.7 Our findings indicate that particularly when smaller doses are prescribed, providers may want to encourage parent use of syringes by providing them with a syringe to take home; cups may be acceptable for larger doses. Because parents may not use tools provided to them, counseling and general education about the importance and proper use of standard dosing tools remain important.

    Interestingly, parents made more errors with dose amounts of 2.5 and 7.5 mL overall, compared with 5 mL, suggesting that whole numbers may be better understood. Additional study is needed to explore the potential benefit of limiting doses to whole number amounts.

    Notably, the simplification of syringes with fewer markings was not associated with a difference in errors. It may be that parents benefit so much from using a syringe over a cup that the added benefit of simplification of markings is not discernible. Few studies have examined the implications of variations in markings in depth; for this study, we were able to look at only 2 variations. It remains possible that other strategies to simplify markings (eg, inclusion of only markings specific to recommended doses) could influence error rates.

    This study has the following limitations. Errors were identified via a hypothetical assessment and might not reflect how parents actually dose at home. Parents measured medications as part of 9 trials, and test order was associated with error, consistent with a learning effect; however, the order in which each trial was conducted was randomized, and order was adjusted for in models. To minimize subject burden, a limited range of doses were tested, and only cups and oral syringes were tested. Tools were marked only in English, reflecting current standard practices. Not all potential unit pairings were included; we selected 5 common pairings. We did not include pairings involving mismatches of greater discordance such as a teaspoon label with a milliliter tool, because it is well established that complete mismatches should be avoided. Only 1 label design format was used. Our study focused on measurement, and not on other issues involved in the administration of medications to a child (eg, spillage). This study was conducted with English- and Spanish-speaking parents who brought their children to 3 university-affiliated pediatric clinic sites serving predominantly low-income families; results may not be generalizable.

    Conclusions

    Findings from this study can be used to build on existing AAP policies related to milliliter-only dosing and provision of standardized dosing tools,7,24 to promote the safe use of pediatric liquid medications. Our findings suggest that health care providers should encourage oral syringe use for the measurement of liquid medications, particularly when small doses are recommended; this change would probably benefit all families, regardless of health literacy and language. The types of unit of measurement discordance between labels and tools we studied appeared to have a limited impact on error rates, although our findings support avoidance of using teaspoon alone on labels. Notably, even when syringes were used with concordant milliliter-only labels and tools, parents made 1 or 2 errors on average across the 9 trials in this experiment. Future studies are needed to examine additional strategies (eg, pictograms, tool size) to reduce errors and to test strategies in real-world settings.

    Acknowledgments

    We thank our research staff, including Purvi Tailor Raythatha, BSc (Pharm). We also thank the staff of the pediatric outpatient clinics at Bellevue Hospital Center, Gardner Packard Children’s Health Care Center, and Children’s Healthcare of Atlanta at Hughes Spaulding for their support. We thank Comar for helping our team develop customized medication dosing tools for this project.

    Footnotes

      • Accepted July 7, 2016.
    • Address correspondence to H. Shonna Yin, MD, MS, New York University School of Medicine, Dept of Pediatrics, 550 First Ave, NBV 8S4-11, New York, NY 10016. E-mail: yinh02{at}med.nyu.edu
    • Preliminary findings from this study were presented in part at the 2015 Pediatric Academic Societies meeting (April 25, 2015; San Diego, CA) and at 2 meetings of the Centers for Disease Control and Prevention's PrOTECT (Prevention of Overdoses & Treatment Errors in Children Taskforce) initiative (November 13, 2014 and November 4, 2015; Atlanta, GA).

    • This trial has been registered at www.clinicaltrials.gov (identifier NCT01854151).

    • FINANCIAL DISCLOSURE: Drs Bailey, Parker, and Wolf and Ms Jacobson have served as consultants to and received grant funding from Merck, Sharp and Dohme for work unrelated to this study.

    • FUNDING: Supported by the National Institutes of Health (NIH) National Institute of Child Health and Human Development (grant R01HD070864). Dr Yin is supported by Health Resources & Services Administration grant 12-191-1077, Academic Administrative Units in Primary Care. Dr Sanders is supported by a US Food and Drug Administration Centers of Excellence in Regulatory Science and Innovation grant (University of California, San Francisco–Stanford Centers of Excellence in Regulatory Science and Innovation Award 13). Funded by the National Institutes of Health (NIH).

    • POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

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    Liquid Medication Errors and Dosing Tools: A Randomized Controlled Experiment
    H. Shonna Yin, Ruth M. Parker, Lee M. Sanders, Benard P. Dreyer, Alan L. Mendelsohn, Stacy Bailey, Deesha A. Patel, Jessica J. Jimenez, Kwang-Youn A. Kim, Kara Jacobson, Laurie Hedlund, Michelle C. J. Smith, Leslie Maness Harris, Terri McFadden, Michael S. Wolf
    Pediatrics Oct 2016, 138 (4) e20160357; DOI: 10.1542/peds.2016-0357

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    Liquid Medication Errors and Dosing Tools: A Randomized Controlled Experiment
    H. Shonna Yin, Ruth M. Parker, Lee M. Sanders, Benard P. Dreyer, Alan L. Mendelsohn, Stacy Bailey, Deesha A. Patel, Jessica J. Jimenez, Kwang-Youn A. Kim, Kara Jacobson, Laurie Hedlund, Michelle C. J. Smith, Leslie Maness Harris, Terri McFadden, Michael S. Wolf
    Pediatrics Oct 2016, 138 (4) e20160357; DOI: 10.1542/peds.2016-0357
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