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American Academy of Pediatrics
SUPPLEMENT ARTICLE

Early Identification and Interventions for Autism Spectrum Disorder: Executive Summary

Lonnie Zwaigenbaum, Margaret L. Bauman, Roula Choueiri, Deborah Fein, Connie Kasari, Karen Pierce, Wendy L. Stone, Nurit Yirmiya, Annette Estes, Robin L. Hansen, James C. McPartland, Marvin R. Natowicz, Timothy Buie, Alice Carter, Patricia A. Davis, Doreen Granpeesheh, Zoe Mailloux, Craig Newschaffer, Diana Robins, Susanne Smith Roley, Sheldon Wagner and Amy Wetherby
Pediatrics October 2015, 136 (Supplement 1) S1-S9; DOI: https://doi.org/10.1542/peds.2014-3667B
Lonnie Zwaigenbaum
aDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada;
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Margaret L. Bauman
bDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts;
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Roula Choueiri
cDivision of Developmental and Behavioral Pediatrics, University of Massachusetts Memorial Children’s Medical Center, Worcester, Massachusetts;
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Deborah Fein
dDepartment of Psychology, University of Connecticut, Storrs, Connecticut;
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Connie Kasari
eGraduate School of Education & Information Studies, University of California Los Angeles, Los Angeles, California;
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Karen Pierce
fDepartment of Neurosciences, University of California San Diego, La Jolla, California;
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Wendy L. Stone
gDepartments of Psychology, and
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Nurit Yirmiya
hDepartment of Psychology, Hebrew University of Jerusalem Mount Scopus, Jerusalem, Israel;
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Annette Estes
iSpeech and Hearing Sciences, University of Washington, Seattle, Washington;
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Robin L. Hansen
jDepartment of Pediatrics, University of California Davis MIND Institute, Sacramento, California;
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James C. McPartland
kYale Child Study Center, New Haven, Connecticut;
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Marvin R. Natowicz
lGenomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio;
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Timothy Buie
mHarvard Medical School and Massachusetts General Hospital for Children, Boston, Massachusetts;
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Alice Carter
nDepartment of Psychology, University of Massachusetts, Boston, Massachusetts;
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Patricia A. Davis
oIntegrated Center for Child Development, Newton, Massachusetts;
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Doreen Granpeesheh
pCenter for Autism and Related Disorders, Tarzana, California;
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Zoe Mailloux
qDepartment of Occupational Therapy, Thomas Jefferson University, Philadelphia, Pennsylvania;
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Craig Newschaffer
rA.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania;
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Diana Robins
rA.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania;
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Susanne Smith Roley
sUSC Mrs T.H. Chan Division of Occupational Science and Occupational Therapy, Los Angeles, California;
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Sheldon Wagner
tBehavioral Development & Educational Services, New Bedford, Massachusetts; and
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Amy Wetherby
uDepartment of Clinical Sciences, Florida State University College of Medicine, Tallahassee, Florida
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  • Abbreviations:
    ASD —
    autism spectrum disorder
    DSM-5 —
    Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
    M-CHAT —
    Modified Checklist for Autism in Toddlers
  • Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired social communication skills and isolated areas of interest.1 The current prevalence of these disorders is estimated to be 1 in 68,2 and recent estimates of the risk of recurrence in families with at least 1 child diagnosed with ASD are 10% to 19%.3–5 Advances have been made in identifying genetic variants that can account for biological vulnerability to ASD,6,7 although recent studies examining patterns of heredity implicate environmental factors and potential gene-by-environment interactions.8 Although the exact etiology remains unknown in most families, some researchers suggest that the pathogenesis of the disorder begins during prenatal life.9,10 It is likely that ASD is heterogeneous in its etiology as well as in its clinical presentation.11

    The American Academy of Pediatrics has recommended screening for ASDs at 18 and 24 months of age,12 but recent research suggests that atypical behaviors may be detectable in some children at even younger ages.13,14 However, we are still learning how the timing and developmental course of early ASD symptoms vary across children and how best to detect such symptoms across the continuum of children seen in community practice. In addition, reports15 that early intervention can improve developmental and behavioral outcomes in infants and toddlers have lent urgency to identifying children across the autism spectrum at an earlier age. Advances in genetic, neuroimaging, and other neurobiological research have also raised the potential of biomarker screening. Given the progress in these areas, a review of the current state of the science on early identification, screening, and intervention of ASD was warranted.

    These issues were the focus of an international, multidisciplinary panel of clinical practitioners and researchers with expertise in ASD and developmental disabilities. A meeting of the panel was convened in Marina del Rey, California in October, 2010, to develop best practice standards for early identification, screening, and early intervention for ASD in very young children and to identify priorities for future research. To complement previously published reports, our literature review on early identification and screening for ASD focused on children aged ≤24 months, whereas our review of intervention studies focused on children aged ≤36 months. The panel reached consensus in 3 areas:

    • What are the earliest signs and symptoms of ASD in children aged ≤24 months that can be used for early identification?

    • How can we optimize developmental course and outcomes through ASD screening programs for children aged ≤24 months?

    • What interventions have shown efficacy in children with ASD aged <36 months?

    Methods

    Before the conference, participants were assigned to 1 of 3 working groups, each comprising 7 to 10 experts and focusing on the early identification of ASD, early screening, and early interventions and outcomes. The Early Identification group comprised Drs Stone, Yirmiya (co-chairs), Chawarska, Estes, Hansen, McPartland, and Natowicz. The Early Screening group comprised Drs Fein, Pierce (co-chairs), Baranek, Davis, Newschaffer, Robins, and Wetherby. The Early Intervention and Treatment Outcome group comprised Drs Choueiri, Kasari (co-chairs), Buie, Carter, Charman, Granpeesheh, Mailloux, Mesibov, Smith Roley, and Wagner.

    To inform the work of each group, literature searches were conducted on Medline to identify relevant articles for each topic (the specific search terms are provided in the other articles in this supplement to Pediatrics16–18). Search results were complemented by additional publications identified by working group members. Although the search strategy was comprehensive, selection of articles was not systematic, which is an important limitation. A scoping approach, with some discretion by consensus of the multidisciplinary expert working group, was used instead to select articles of highest relevance and methodologic quality. Articles were assigned to working group members for review.

    During the conference, each group presented a synthesis of the current literature and offered draft recommendations for discussion, modification, and ratification by all attendees. Electronic voting was used to express opinions and guide consensus building. A modified nominal group technique was used to review the recommendations, with consensus reached by ≥1 round of voting. A total of 18 to 21 participants voted on 28 statements, and 16 statements received solely agree or strongly agree votes. The number of statements was condensed to 25 during the writing process. The first statement pertains to the literature review as a whole, with subsequent statements specific to each of the 3 sections. Some of the statements summarize the state of the literature, whereas others are in the form of recommendations for research needed to deal with outstanding questions or aimed at addressing important clinical practice issues.

    More recent peer-reviewed research was subsequently incorporated to ensure that the final article reflected the most recent literature. The search for each topic (ie, early identification, screening, intervention) was updated by using the same strategy to add articles published to December 31, 2013. Evidence tables and text references were updated, and the working group reviewed and approved the final wording of the summary and recommendations.

    We recognize that transition to recently published criteria for ASD as delineated by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5),1 may recast diagnostic boundaries, at least to some degree.19,20 At this point, it is probably too soon to tell how the revised diagnostic criteria will affect the identification and management of the ASDs, but it is likely that key principles regarding best practice and the “state of the science” from previous research will apply to DSM-5–defined ASD.

    Results

    Consensus statements are summarized in Tables 1, 2, and 3 and are discussed in detail in the other articles of this supplement to Pediatrics.16–18 These other articles include tables summarizing the original research articles that support the recommendations.

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    TABLE 1

    Consensus Statements on Early Identification of ASD

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    TABLE 2

    Consensus Statements on Early Screening of ASD

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    TABLE 3

    Consensus Statements on Early Intervention and Outcomes of ASD

    Discussion

    Early diagnosis and intervention can have a significant positive impact on the developmental outcomes of children with ASD21,22 and can also improve parental well-being by addressing concerns and reducing the stress associated with untreated ASD and co-morbid behavioral challenges.23 Moreover, the human brain undergoes a profound period of establishing and refining connections between neurons during the first years of life. For example, synaptic density in the human prefrontal cortex (ie, the brain region centrally involved in higher order social behavior) peaks between 1 and 2 years of age.24 Synaptic density in language areas, such as Wernicke’s and Broca’s areas, peaks shortly thereafter by age 3 years. A period of refinement occurs after peaks in synapse number, during which effective connections are strengthened and weak ones die away. This important developmental step, namely the construction of specific neural circuits and the pruning of excess (unused) synapses, is believed to depend largely on input from the environment.25 Thus, early identification and intervention either before or while brain connections are being established may enable optimal prognosis.

    The present review highlights the constellation of ASD-related symptoms emerging by the second year of life, the potential utility of clinical screening to facilitate early identification, and the growing number of empirically supported interventions for very young children. Considerable progress has been made over the past decade in delineating the ASD phenotype during the first 2 years of life, providing a solid foundation for early diagnosis. Moreover, there have been parallel advances in intervention research, ensuring that early diagnosis can lead to substantially improved outcomes. However, much work remains to be done to ensure that children across the ASD spectrum can benefit from clinical and therapeutic advances and that promising model programs can retain their effectiveness when implemented across a broad range of family and community contexts.

    There is now robust evidence across a diversity of study designs that behavioral signs of ASD can be detected in the second year of life. Highly replicated findings point to impairments in social attention (eg, reduced response to name) and social communication (eg, reduced joint attention behaviors), as well as atypical object use (eg, repetitive actions such as tapping and spinning) and abnormal visual attention, emerging by 12 to 18 months of age in children subsequently diagnosed with ASD. Other potential early markers which have been less extensively studied but that may also contribute to identifying at-risk toddlers include unusual body movements, atypical emotional regulation, and reduced motor control. Although research to date has not yet identified clear behavioral markers of ASD in infants aged <12 months, evidence is growing that developmental trajectories (ie, change over time) in early social orienting and language and cognitive skills beginning as early as 6 months can be predictive of ASD.26,27 Thus, longitudinal studies of at-risk infants (eg, those with an older sibling with ASD), as well as those detected early in the general population, may be particularly informative. Such studies have the added advantage of including the potential to evaluate both biological and behavioral markers, the combination of which may further aid in early identification. Future longitudinal research would benefit from the use of both high- and low-risk comparison groups, to ensure that risk profiles adequately distinguish between ASD and other developmental disorders, rather than just ASD and typical development.

    Our review of published research evaluating ASD screening tools (Table 3) supports current American Academy of Pediatrics’ recommendations of ASD screening in the second year.28 These tools include both those targeted at ASD-specific behaviors (eg, the Modified Checklist for Autism in Toddlers [M-CHAT]) as well as measures targeting a broader range of delays (eg, the Communication and Symbolic Behavior Scales Infant/Toddler Checklist). Data from large community-based samples suggest that ASD screening by using the M-CHAT (specifically, its current version [revised, with follow-up])29 or the Infant/Toddler Checklist30 can identify children with ASD earlier and with greater sensitivity compared with open-ended questions regarding parental concerns and thus offers advantages over general developmental surveillance. There is some support for the potential utility of ASD screening before 18 months of age. For example, a positive screen on the Infant/Toddler Checklist at 12 months (as part of the First Year Check-Up model)31 was associated with a positive predictive value of 0.75 for ASD or other developmental delays but with considerable loss to follow-up (based on the ∼1 in 7 screen-positive children who were ultimately seen for diagnostic assessment).

    Other ASD screens targeting this younger age group have shown some promise. For example, the Early Screening of Autistic Traits questionnaire can identify ASD as early as 14 months but with a low case detection rate and presumably low sensitivity,32 and the First Year Inventory may detect some children with ASD at 12 months but also with only modest sensitivity.33 Further research on ASD screening for this age group is needed. It is also recognized that younger siblings of children with ASD are at substantial risk for the disorder (with estimated recurrence as high as 18.7%),4 as well as other developmental challenges,34 and thus warrant additional monitoring. It is also important to take into consideration what populations have been investigated for currently available screens (Table 3) and the degree to which this analysis may influence generalizability to other contexts. For example, community pediatric practices can be a highly informative setting to assess the screening properties of particular measures in children without specific risk factors but may not fully reflect the diversity (eg, socioeconomic, ethnic) of a true population sample. Screening must be linked to timely referral for additional evaluation for risk-positive children as well as prompt access to interventions targeted to specific, identified functional concerns while diagnostic status is being clarified. Earlier research suggests only a modest increase in ASD screening in pediatric practice35; the routine implementation of diagnostic measures could be enhanced, however, by providing administrative support to assist with processing completed screens and facilitating subsequent referrals.31,36 Placing screening in the broader context of ASD assessment may also help engage community physicians.37 Additional barriers, including third-party reimbursement, lack of monitoring systems to track positive screening results, and challenges accessing early intervention services, need to be addressed to enhance incorporation of recommended screening practices into routine care for community practitioners.

    Although some studies have reported that screening can identify children with ASD earlier and more consistently than routine inquiry about parental concerns,31 none has examined whether interventions offered to children with ASD identified solely according to screening yield improved outcomes. Indeed, screening effectiveness is generally assessed with respect to classification accuracy (ie, sensitivity and specificity) rather than clinically meaningful outcomes (ie, changes in developmental trajectories related to earlier initiation of intervention), an important focus for future ASD screening research.

    Considerable progress has also been made in developing and evaluating ASD intervention models specific to the needs of children <3 years of age. Several groups have adapted treatments initially designed for older preschool-aged children with ASD by integrating best practice in behavioral teaching methods into a developmental framework based on current scientific understanding of how infants and toddlers learn. The central role of parents has been emphasized, and interventions are designed to incorporate learning opportunities into everyday activities, capitalize on “teachable moments,” and facilitate the generalization of skills beyond the familiar home setting. Although some trials were limited to 8- to 12-week outcome data, enhanced outcomes associated with some interventions (eg, the Early Start Denver Model) were evaluated over periods lasting as long as 2 years.21

    Although no studies to date have directly compared intervention models in children with ASD aged <3 years (even for older children, such studies are rare), there is clear evidence that interventions initiated at this early age can lead to marked improvements in targeted skills (eg, social communication, imitation)38,39 as well as more global improvements in cognitive and adaptive functions.21,40 Although additional research is needed to further optimize existing models (eg, to differentiate the specific active ingredients), accumulating evidence indicates that toddlers with ASD benefit from early, diagnosis-specific interventions, thus placing greater urgency on the need to ensure broader dissemination and uptake of evidence-based practices beyond initial research settings. Recent data41 that such interventions not only improve adaptive and social behaviors but also lead to normalized patterns of brain activity in response to viewing faces further emphasize the potential to improve long-term neurodevelopmental trajectories. Efforts to implement effective research programs in formats that can reach larger numbers of children through innovative training approaches (eg, an Internet-based distance learning model for Early Start Denver Model therapists) have also been encouraging.42

    Study Limitations

    The recommendations outlined in the present article (and discussed in greater detail in the other articles comprising this supplement16–18) were informed by a review of the published literature as well as consensus of our expert group. However, it is important to acknowledge that the selection of articles for review by the working groups was not systematic. A scoping approach was instead used to select articles of highest relevance and methodologic quality; it is possible that this process excluded key references that might have further informed the recommendations.

    Future Directions

    Whereas better and earlier characterization of behavioral symptoms should continue to be a significant focus of research (especially those early characteristics that can be more easily applied in clinical practice), the active search for underlying biological markers should remain a high priority. Promising findings from neuroimaging43–45 and neuroelectrophysiology46 studies may also guide future biomarker-based strategies. For example, the observation of enlarged brain volume early in life could be useful in some cases. In addition, the pursuit of biologic examination of cord blood, placenta, maternal blood, and amniotic fluid, when available, may provide useful and more feasible resources for defining very early indicators of atypical neurologic development and might ultimately lead to more specific treatment modalities.

    Although disturbances in sensory processing have not always been considered a core feature of ASD, atypical sensory processing is frequently reported by parents, therapists, teachers, and patients themselves. With the publication of the DSM-5 in May 2013, unusual sensory responses were included in the restricted and repetitive interests/behaviors domain, thus acknowledging that these symptoms play a role in ASD.47 More recently, imaging and neurophysiologic studies have reported abnormalities in the white matter microstructure of the brain in children with sensory-processing disorders.48,49 How disorders of sensory processing50 (including modulation and integration of sensory information) influence many of the behaviors, and potentially some of the core features of ASD,51 remains poorly understood and will be an important area for future research; understanding these mechanisms could have important implications for early diagnosis and treatment.

    There is a growing appreciation that ASD is heterogeneous in its causes, underlying neurobiology, and clinical presentation and that the “autisms” comprise a continuum of signs and symptoms, many of which may change over time, either as the result of age or therapeutic interventions or both. Currently, we have little understanding of the natural life history of ASD and how the clinical changes in any individual patient may be reflective of underlying neurobiological mechanism(s) not yet defined. Large-scale longitudinal studies designed to follow up cohorts of well-characterized individuals over time and examine the interplay between biological processes and subsequent experiences could generate new insights to help better individualize treatment strategies.

    When considering research related to intervention outcomes, a more concerted focus should be placed on the investigation of those children with ASD who make dramatic progress, some of whom eventually “lose” their diagnosis (ie, the optimal outcome),52 and those who, despite well-designed, high-quality programs and strong family support, fail to make any significant improvement. Defining the differences between these 2 groups could potentially provide important information relative to the underlying causes of these subsets of children and, furthermore, what specific interventions should be tailored to which type of child. Other indices of heterogeneity (eg, symptom severity, variation in cognitive and language levels, comorbid behavioral and medical conditions) should be more explicitly considered in future studies to help better understand variation in intervention outcomes. It will also be essential that we learn more about how such diversity can affect the effectiveness of early detection and screening, and how this information can help us to develop multipronged strategies that lead to earlier diagnosis across the autism spectrum.

    The potential effects of co-morbid medical conditions on the behavior, developmental progress, and general well-being of children with ASD are becoming increasingly apparent and warrant careful consideration, even in the context of early intervention. The autism community has begun to appreciate that a variety of medical conditions (including gastrointestinal disorders, sleep, airway obstruction related to enlarged tonsils and adenoids, and obesity) can—and do—occur among children with ASD and, when present, can negatively affect developmental progress and quality of life. Furthermore, some of the behaviors frequently associated with ASD (eg, stereotypies, aggression, self-injury) are often related to the pain and discomfort associated with these underlying medical conditions. It will be important to determine the prevalence of these co-morbid conditions; to identify their presenting symptoms, which may differ from those seen in typically developing children; and to effectively treat these conditions in concert with other interventions.

    Future research related to early identification, screening, and intervention should address the impact of social and cultural beliefs and values, family expectations, stresses and involvement, and outcome goals. Belief systems among service providers may influence utilization of early detection and screening and referral to specialized assessment and interventions.53 Belief systems among families regarding social behavior and development, in addition to earlier experiences with health care providers, can influence communication regarding early risk markers and participation in screening programs. Cultural beliefs, as well as family dynamics and socioeconomic circumstances, can also influence a family’s effective engagement in intervention programs and thus may ultimately affect outcomes.54 Future research should take into account the diversity of beliefs and world views among families and consider how to adapt early detection, screening, and intervention strategies to minimize health disparities or systemic practices that marginalize historically underserved groups to ensure that barriers and health care disparities are overcome. The goal of treatment is early detection, diagnosis, and access to effective interventions for all children across the autism spectrum.

    Acknowledgments

    The conference chairs and working groups acknowledge the preconference contributions of individuals who were unable to attend the conference, including Grace Baranek, PhD, OTR/L, FAOTA, Tony Charman, PhD, Katarzyna Chawarska, PhD, and Gary Mesibov, PhD. We also acknowledge the efforts of Katherine F. Murray, BSN, RN, Massachusetts General Hospital for Children, in coordinating the forum and subsequent conference report process, and Sifor Ng in the conference report process.

    The meeting and consensus report were sponsored by the Autism Forum. An important goal of the forum is to identify early indicators of ASDs that may lead to effective health care services. Autism Forum programs are developed under the guidance of its parent organization, the Northwest Autism Foundation. For this project, the Autism Research Institute provided financial support.

    Footnotes

      • Accepted August 3, 2015.
    • Address correspondence to Lonnie Zwaigenbaum, MD, Autism Research Center, Glenrose Rehabilitation Hospital, Room E209, 10230 111 Ave, Edmonton, AB, Canada T5G 0B7. E-mail: lonniez{at}ualberta.ca
    • Drs Zwaigenbaum and Bauman initiated a literature review, co-chaired the meeting that generated the consensus recommendations outlined in this article, and drafted the initial manuscript; Drs Choueiri, Fein, Kasari, Pierce, Stone, and Yirmiya co-chaired the working groups that conducted the literature review, generated initial recommendations that were discussed at the consensus meeting, and provided critical input to subsequent drafts of the manuscript; Drs Estes, Hansen, McPartland, Natowicz, Buie, Carter, Davis, Granpeesheh, Mailloux, Newschaffer, Robins, Smith Roley, Wagner, and Wetherby were members of the working groups that reviewed selected publications, contributed to recommendations, and critically reviewed the manuscript; and all authors approved the final manuscript as submitted.

    • FINANCIAL DISCLOSURE: Dr Zwaigenbaum was the site Principal Investigator of a study sponsored by SynapDx (he received operating funds but no honoraria). Drs Fein and Robins are co-owners of M-CHAT, LLC, which licenses use of the Modified Checklist for Autism in Toddlers in electronic products. Dr Stone is the author of the Screening Tool for Autism in Two-Year-Olds and receives a share of royalties from sales of this instrument. The authors received an honorarium as well as travel expenses from Autism Forum for contributing to the expert panels.

    • FUNDING: Sponsored by the Autism Forum under the guidance of the Northwest Autism Foundation and with the support of the Autism Research Institute.

    • POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

    References

    1. ↵
      American Psychiatric Association. Diagnostic and Statistical Manual of Mental Health Disorders: DSM-5. 5th ed. Washington, DC: American Psychiatric Association; 2013
    2. ↵
      1. Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators,
      2. Centers for Disease Control and Prevention
      . Prevalence of autism spectrum disorders—Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ. 2012;61(3):1–19pmid:22456193
      OpenUrlPubMed
    3. ↵
      1. Constantino JN,
      2. Zhang Y,
      3. Frazier T,
      4. Abbacchi AM,
      5. Law P
      . Sibling recurrence and the genetic epidemiology of autism. Am J Psychiatry. 2010;167(11):1349–1356pmid:20889652
      OpenUrlCrossRefPubMed
    4. ↵
      1. Ozonoff S,
      2. Young GS,
      3. Carter A,
      4. et al
      . Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study. Pediatrics. 2011;128(3). Available at: www.pediatrics.org/cgi/content/full/128/3/e488pmid:21844053
      OpenUrlAbstract/FREE Full Text
    5. ↵
      1. Grønborg TK,
      2. Schendel DE,
      3. Parner ET
      . Recurrence of autism spectrum disorders in full- and half-siblings and trends over time: a population-based cohort study. JAMA Pediatr. 2013;167(10):947–953pmid:23959427
      OpenUrlCrossRefPubMed
    6. ↵
      1. Jiang YH,
      2. Yuen RK,
      3. Jin X,
      4. et al
      . Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am J Hum Genet. 2013;93(2):249–263pmid:23849776
      OpenUrlCrossRefPubMed
    7. ↵
      1. Carter MT,
      2. Scherer SW
      . Autism spectrum disorder in the genetics clinic: a review. Clin Genet. 2013;83(5):399–407pmid:23425232
      OpenUrlCrossRefPubMed
    8. ↵
      1. Hallmayer J,
      2. Cleveland S,
      3. Torres A,
      4. et al
      . Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry. 2011;68(11):1095–1102pmid:21727249
      OpenUrlCrossRefPubMed
    9. ↵
      1. Gardener H,
      2. Spiegelman D,
      3. Buka SL
      . Prenatal risk factors for autism: comprehensive meta-analysis. Br J Psychiatry. 2009;195(1):7–14pmid:19567888
      OpenUrlAbstract/FREE Full Text
    10. ↵
      1. Courchesne E,
      2. Mouton PR,
      3. Calhoun ME,
      4. et al
      . Neuron number and size in prefrontal cortex of children with autism. JAMA. 2011;306(18):2001–2010pmid:22068992
      OpenUrlCrossRefPubMed
    11. ↵
      1. Waterhouse L
      . Rethinking Autism: Variation and Complexity. London, United Kingdom: Academic Press; 2013
    12. ↵
      1. Myers SM,
      2. Johnson CP,
      3. American Academy of Pediatrics Council on Children With Disabilities
      . Management of children with autism spectrum disorders. Pediatrics. 2007;120(5):1162–1182pmid:17967921
      OpenUrlAbstract/FREE Full Text
    13. ↵
      1. Zwaigenbaum L,
      2. Bryson S,
      3. Lord C,
      4. et al
      . Clinical assessment and management of toddlers with suspected autism spectrum disorder: insights from studies of high-risk infants. Pediatrics. 2009;123(5):1383–1391pmid:19403506
      OpenUrlAbstract/FREE Full Text
    14. ↵
      1. Zwaigenbaum L,
      2. Bryson S,
      3. Garon N
      . Early identification of autism spectrum disorders. Behav Brain Res. 2013;251:133–146pmid:23588272
      OpenUrlCrossRefPubMed
    15. ↵
      1. Wallace KS,
      2. Rogers SJ
      . Intervening in infancy: implications for autism spectrum disorders. J Child Psychol Psychiatry. 2010;51(12):1300–1320pmid:20868374
      OpenUrlCrossRefPubMed
    16. ↵
      Zwaigenbaum L, Bauman ML, Stone WL, et al. Early identification of autism spectrum disorder: recommendations for practice and research. Pediatrics. 2015;136(suppl X)XXX–XXX
    17. Zwaigenbaum L, Bauman ML, Fein D, et al. Early screening of autism spectrum disorder: recommendations for practice and research. Pediatrics. 2015;136(suppl X)XXX–XXX
    18. ↵
      Zwaigenbaum L, Bauman ML, Choueiri R, et al. Early intervention for children with autism spectrum disorder under 3 years of age: recommendations for practice and research. Pediatrics. 2015;136(suppl X)XXX–XXX
    19. ↵
      1. McPartland JC,
      2. Reichow B,
      3. Volkmar FR
      . Sensitivity and specificity of proposed DSM-5 diagnostic criteria for autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 2012;51(4):368–383pmid:22449643
      OpenUrlCrossRefPubMed
    20. ↵
      1. Huerta M,
      2. Bishop SL,
      3. Duncan A,
      4. Hus V,
      5. Lord C
      . Application of DSM-5 criteria for autism spectrum disorder to three samples of children with DSM-IV diagnoses of pervasive developmental disorders. Am J Psychiatry. 2012;169(10):1056–1064pmid:23032385
      OpenUrlCrossRefPubMed
    21. ↵
      1. Dawson G,
      2. Rogers S,
      3. Munson J,
      4. et al
      . Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model. Pediatrics. 2010;125(1). Available at: www.pediatrics.org/cgi/content/full/125/1/e17pmid:19948568
      OpenUrlAbstract/FREE Full Text
    22. ↵
      1. Kasari C,
      2. Gulsrud AC,
      3. Wong C,
      4. Kwon S,
      5. Locke J
      . Randomized controlled caregiver mediated joint engagement intervention for toddlers with autism. J Autism Dev Disord. 2010;40(9):1045–1056pmid:20145986
      OpenUrlCrossRefPubMed
    23. ↵
      1. Estes A,
      2. Munson J,
      3. Dawson G,
      4. Koehler E,
      5. Zhou XH,
      6. Abbott R
      . Parenting stress and psychological functioning among mothers of preschool children with autism and developmental delay. Autism. 2009;13(4):375–387pmid:19535467
      OpenUrlAbstract/FREE Full Text
    24. ↵
      1. Huttenlocher PR
      . Synaptic density in human frontal cortex—developmental changes and effects of aging. Brain Res. 1979;163(2):195–205pmid:427544
      OpenUrlCrossRefPubMed
    25. ↵
      1. Quartz SR,
      2. Sejnowski TJ
      . The neural basis of cognitive development: a constructivist manifesto. Behav Brain Sci. 1997;20(4):537–556, discussion 556–596pmid:10097006
      OpenUrlCrossRefPubMed
    26. ↵
      1. Jones W,
      2. Klin A
      . Attention to eyes is present but in decline in 2-6-month-old infants later diagnosed with autism. Nature. 2013;504(7480):427–431pmid:24196715
      OpenUrlCrossRefPubMed
    27. ↵
      1. Landa RJ,
      2. Gross AL,
      3. Stuart EA,
      4. Faherty A
      . Developmental trajectories in children with and without autism spectrum disorders: the first 3 years. Child Dev. 2013;84(2):429–442pmid:23110514
      OpenUrlCrossRefPubMed
    28. ↵
      1. Johnson CP,
      2. Myers SM,
      3. American Academy of Pediatrics Council on Children With Disabilities
      . Identification and evaluation of children with autism spectrum disorders. Pediatrics. 2007;120(5):1183–1215pmid:17967920
      OpenUrlAbstract/FREE Full Text
    29. ↵
      1. Robins DL,
      2. Casagrande K,
      3. Barton M,
      4. Chen CM,
      5. Dumont-Mathieu T,
      6. Fein D
      . Validation of the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F). Pediatrics. 2014;133(1):37–45pmid:24366990
      OpenUrlAbstract/FREE Full Text
    30. ↵
      1. Wetherby AM,
      2. Brosnan-Maddox S,
      3. Peace V,
      4. Newton L
      . Validation of the Infant-Toddler Checklist as a broadband screener for autism spectrum disorders from 9 to 24 months of age. Autism. 2008;12(5):487–511pmid:18805944
      OpenUrlAbstract/FREE Full Text
    31. ↵
      Pierce K, Carter C, Weinfeld M, et al. Detecting, studying, and treating autism early: the one-year well-baby check-up approach. J Pediatr. 2011;159(3):458–465.e1–e6
    32. ↵
      1. Dietz C,
      2. Swinkels S,
      3. van Daalen E,
      4. van Engeland H,
      5. Buitelaar JK
      . Screening for autistic spectrum disorder in children aged 14-15 months. II: population screening with the Early Screening of Autistic Traits Questionnaire (ESAT). Design and general findings. J Autism Dev Disord. 2006;36(6):713–722pmid:16633887
      OpenUrlCrossRefPubMed
    33. ↵
      1. Reznick JS,
      2. Baranek GT,
      3. Reavis S,
      4. Watson LR,
      5. Crais ER
      . A parent-report instrument for identifying one-year-olds at risk for an eventual diagnosis of autism: the first year inventory. J Autism Dev Disord. 2007;37(9):1691–1710pmid:17180716
      OpenUrlCrossRefPubMed
    34. ↵
      1. Messinger D,
      2. Young GS,
      3. Ozonoff S,
      4. et al
      . Beyond autism: a baby siblings research consortium study of high-risk children at three years of age. J Am Acad Child Adolesc Psychiatry. 2013;52(3):300–308.e1pmid:23452686
      OpenUrlCrossRefPubMed
    35. ↵
      1. Dosreis S,
      2. Weiner CL,
      3. Johnson L,
      4. Newschaffer CJ
      . Autism spectrum disorder screening and management practices among general pediatric providers. J Dev Behav Pediatr. 2006;27(suppl 2):S88–S94pmid:16685190
      OpenUrlCrossRefPubMed
    36. ↵
      1. Miller JS,
      2. Gabrielsen T,
      3. Villalobos M,
      4. et al
      . The each child study: systematic screening for autism spectrum disorders in a pediatric setting. Pediatrics. 2011;127(5):866–871pmid:21482605
      OpenUrlAbstract/FREE Full Text
    37. ↵
      1. Warren Z,
      2. Stone W,
      3. Humberd Q
      . A training model for the diagnosis of autism in community pediatric practice. J Dev Behav Pediatr. 2009;30(5):442–446pmid:19823138
      OpenUrlCrossRefPubMed
    38. ↵
      1. Kasari C,
      2. Freeman S,
      3. Paparella T
      . Joint attention and symbolic play in young children with autism: a randomized controlled intervention study. J Child Psychol Psychiatry. 2006;47(6):611–620pmid:16712638
      OpenUrlCrossRefPubMed
    39. ↵
      1. Kasari C,
      2. Paparella T,
      3. Freeman S,
      4. Jahromi LB
      . Language outcome in autism: randomized comparison of joint attention and play interventions. J Consult Clin Psychol. 2008;76(1):125–137pmid:18229990
      OpenUrlCrossRefPubMed
    40. ↵
      1. Smith T,
      2. Groen AD,
      3. Wynn JW
      . Randomized trial of intensive early intervention for children with pervasive developmental disorder. Am J Ment Retard. 2000;105(4):269–285pmid:10934569
      OpenUrlCrossRefPubMed
    41. ↵
      1. Dawson G,
      2. Jones EJ,
      3. Merkle K,
      4. et al
      . Early behavioral intervention is associated with normalized brain activity in young children with autism. J Am Acad Child Adolesc Psychiatry. 2012;51(11):1150–1159pmid:23101741
      OpenUrlCrossRefPubMed
    42. ↵
      1. Vismara LA,
      2. Colombi C,
      3. Rogers SJ
      . Can one hour per week of therapy lead to lasting changes in young children with autism? Autism. 2009;13(1):93–115pmid:19176579
      OpenUrlAbstract/FREE Full Text
    43. ↵
      1. Dinstein I,
      2. Pierce K,
      3. Eyler L,
      4. et al
      . Disrupted neural synchronization in toddlers with autism. Neuron. 2011;70(6):1218–1225pmid:21689606
      OpenUrlCrossRefPubMed
      1. Wolff JJ,
      2. Gu H,
      3. Gerig G,
      4. et al.,
      5. IBIS Network
      . Differences in white matter fiber tract development present from 6 to 24 months in infants with autism. Am J Psychiatry. 2012;169(6):589–600pmid:22362397
      OpenUrlCrossRefPubMed
    44. ↵
      1. Voos AC,
      2. Pelphrey KA,
      3. Tirrell J,
      4. et al
      . Neural mechanisms of improvements in social motivation after pivotal response treatment: two case studies. J Autism Dev Disord. 2013;43(1):1–10pmid:23104615
      OpenUrlCrossRefPubMed
    45. ↵
      1. Elsabbagh M,
      2. Mercure E,
      3. Hudry K,
      4. et al.,
      5. BASIS Team
      . Infant neural sensitivity to dynamic eye gaze is associated with later emerging autism. Curr Biol. 2012;22(4):338–342pmid:22285033
      OpenUrlCrossRefPubMed
    46. ↵
      1. Grzadzinski R,
      2. Huerta M,
      3. Lord C
      . DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes. Mol Autism. 2013;4(1):12pmid:23675638
      OpenUrlCrossRefPubMed
    47. ↵
      1. Marco EJ,
      2. Khatibi K,
      3. Hill SS,
      4. et al
      . Children with autism show reduced somatosensory response: an MEG study. Autism Res. 2012;5(5):340–351pmid:22933354
      OpenUrlCrossRefPubMed
    48. ↵
      1. Owen JP,
      2. Marco EJ,
      3. Desai S,
      4. et al
      . Abnormal white matter microstructure in children with sensory processing disorders. Neuroimage Clin. 2013;2:844–853pmid:24179836
      OpenUrlCrossRefPubMed
    49. ↵
      1. James K,
      2. Miller LJ,
      3. Schaaf R,
      4. Nielsen DM,
      5. Schoen SA
      . Phenotypes within sensory modulation dysfunction. Compr Psychiatry. 2011;52(6):715–724pmid:21310399
      OpenUrlCrossRefPubMed
    50. ↵
      1. Boyd BA,
      2. Baranek GT,
      3. Sideris J,
      4. et al
      . Sensory features and repetitive behaviors in children with autism and developmental delays. Autism Res. 2010;3(2):78–87pmid:20437603
      OpenUrlPubMed
    51. ↵
      1. Sutera S,
      2. Pandey J,
      3. Esser EL,
      4. et al
      . Predictors of optimal outcome in toddlers diagnosed with autism spectrum disorders. J Autism Dev Disord. 2007;37(1):98–107pmid:17206522
      OpenUrlCrossRefPubMed
    52. ↵
      1. Kennedy T,
      2. Regehr G,
      3. Rosenfield J,
      4. Roberts SW,
      5. Lingard L
      . Exploring the gap between knowledge and behavior: a qualitative study of clinician action following an educational intervention. Acad Med. 2004;79(5):386–393pmid:15107277
      OpenUrlCrossRefPubMed
    53. ↵
      1. Mandell DS,
      2. Wiggins LD,
      3. Carpenter LA,
      4. et al
      . Racial/ethnic disparities in the identification of children with autism spectrum disorders. Am J Public Health. 2009;99(3):493–498pmid:19106426
      OpenUrlCrossRefPubMed
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    Early Identification and Interventions for Autism Spectrum Disorder: Executive Summary
    Lonnie Zwaigenbaum, Margaret L. Bauman, Roula Choueiri, Deborah Fein, Connie Kasari, Karen Pierce, Wendy L. Stone, Nurit Yirmiya, Annette Estes, Robin L. Hansen, James C. McPartland, Marvin R. Natowicz, Timothy Buie, Alice Carter, Patricia A. Davis, Doreen Granpeesheh, Zoe Mailloux, Craig Newschaffer, Diana Robins, Susanne Smith Roley, Sheldon Wagner, Amy Wetherby
    Pediatrics Oct 2015, 136 (Supplement 1) S1-S9; DOI: 10.1542/peds.2014-3667B

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    Early Identification and Interventions for Autism Spectrum Disorder: Executive Summary
    Lonnie Zwaigenbaum, Margaret L. Bauman, Roula Choueiri, Deborah Fein, Connie Kasari, Karen Pierce, Wendy L. Stone, Nurit Yirmiya, Annette Estes, Robin L. Hansen, James C. McPartland, Marvin R. Natowicz, Timothy Buie, Alice Carter, Patricia A. Davis, Doreen Granpeesheh, Zoe Mailloux, Craig Newschaffer, Diana Robins, Susanne Smith Roley, Sheldon Wagner, Amy Wetherby
    Pediatrics Oct 2015, 136 (Supplement 1) S1-S9; DOI: 10.1542/peds.2014-3667B
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