Skip to main content

Advertising Disclaimer »

Main menu

  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers
  • Other Publications
    • American Academy of Pediatrics

User menu

  • Log in

Search

  • Advanced search
American Academy of Pediatrics

AAP Gateway

Advanced Search

AAP Logo

  • Log in
  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers

Discover Pediatric Collections on COVID-19 and Racism and Its Effects on Pediatric Health

American Academy of Pediatrics
Article

Atopic Dermatitis, Melatonin, and Sleep Disturbance

Yung-Sen Chang, Yen-Ting Chou, Jyh-Hong Lee, Pei-Lin Lee, Yang-Shia Dai, Chi Sun, Yu-Tsan Lin, Li-Chieh Wang, Hsin-Hui Yu, Yao-Hsu Yang, Chun-An Chen, Kong-Sang Wan and Bor-Luen Chiang
Pediatrics August 2014, 134 (2) e397-e405; DOI: https://doi.org/10.1542/peds.2014-0376
Yung-Sen Chang
aDepartment of Pediatrics, Taipei City Hospital Renai Branch, Taipei City, Taiwan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yen-Ting Chou
bDepartment of Pediatrics, Cardinal Tien Hospital Yonghe Branch, New Taipei City, Taiwan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jyh-Hong Lee
Departments of cPediatrics,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pei-Lin Lee
dInternal Medicine,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yang-Shia Dai
eDermatology, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chi Sun
Departments of cPediatrics,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yu-Tsan Lin
Departments of cPediatrics,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Li-Chieh Wang
Departments of cPediatrics,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hsin-Hui Yu
Departments of cPediatrics,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yao-Hsu Yang
Departments of cPediatrics,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chun-An Chen
Departments of cPediatrics,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kong-Sang Wan
aDepartment of Pediatrics, Taipei City Hospital Renai Branch, Taipei City, Taiwan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bor-Luen Chiang
Departments of cPediatrics,
fGraduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
gMedical Research, National Taiwan University Hospital, Taipei City, Taiwan; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Comments
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Download PDF

Abstract

BACKGROUND AND OBJECTIVES: Sleep disturbance is common in patients with atopic dermatitis (AD). However, studies have largely been questionnaire-based, and the pathophysiology remains unclear. The aims of this study were to determine objective characteristics of sleep disturbance in children with AD and explore contributing factors and clinical predictors.

METHODS: Sleep parameters were measured by actigraphy and polysomnography in 72 patients with AD and 32 controls ages 1 to 18 years. Urinary 6-sulfatoxymelatonin levels, serum cytokines, and total and allergen-specific immunoglobulin E (IgE) levels were also measured.

RESULTS: The patients with AD had significantly reduced sleep efficiency, longer sleep onset latency, more sleep fragmentation, and less nonrapid eye movement sleep. Results from actigraphy correlated well with those from polysomnography. The AD disease severity was associated with sleep disturbance (r = 0.55−0.7), and a Scoring Atopic Dermatitis index of ≥48.7 predicted poor sleep efficiency with a sensitivity of 83.3% and a specificity of 75% (area under the curve = 0.81, P = .001). Lower nocturnal melatonin secretion was significantly associated with sleep disturbance in the patients with AD. Other correlates of sleep disturbance included pruritus, scratching movements, higher total serum IgE levels, and allergic sensitization to dust mite and staphylococcal enterotoxins.

CONCLUSIONS: Poor sleep efficiency is common in children with AD and can be predicted by the Scoring Atopic Dermatitis index. Melatonin and IgE might play a role in the sleep disturbance. Further studies are required to explore the mechanisms and clinical implications, and actigraphy could serve as a useful evaluating tool.

  • sleep disturbance
  • atopic dermatitis
  • actigraphy
  • polysomnography
  • SCORAD
  • melatonin
  • IgE
  • dust mite
  • staphylococcal enterotoxin
  • Accepted May 20, 2014.
  • Copyright © 2014 by the American Academy of Pediatrics

Individual Login

Log in
You will be redirected to aap.org to login or to create your account.

Institutional Login

via Institution

You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.

Log in through your institution

If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

Pay Per Article - You may access this article (from the computer you are currently using) for 2 days for US$25.00

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Offer Reprints

PreviousNext
Back to top

Advertising Disclaimer »

In this issue

Pediatrics
Vol. 134, Issue 2
1 Aug 2014
  • Table of Contents
  • Index by author
View this article with LENS
PreviousNext
Email Article

Thank you for your interest in spreading the word on American Academy of Pediatrics.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Atopic Dermatitis, Melatonin, and Sleep Disturbance
(Your Name) has sent you a message from American Academy of Pediatrics
(Your Name) thought you would like to see the American Academy of Pediatrics web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Request Permissions
Article Alerts
Log in
You will be redirected to aap.org to login or to create your account.
Or Sign In to Email Alerts with your Email Address
Citation Tools
Atopic Dermatitis, Melatonin, and Sleep Disturbance
Yung-Sen Chang, Yen-Ting Chou, Jyh-Hong Lee, Pei-Lin Lee, Yang-Shia Dai, Chi Sun, Yu-Tsan Lin, Li-Chieh Wang, Hsin-Hui Yu, Yao-Hsu Yang, Chun-An Chen, Kong-Sang Wan, Bor-Luen Chiang
Pediatrics Aug 2014, 134 (2) e397-e405; DOI: 10.1542/peds.2014-0376

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Atopic Dermatitis, Melatonin, and Sleep Disturbance
Yung-Sen Chang, Yen-Ting Chou, Jyh-Hong Lee, Pei-Lin Lee, Yang-Shia Dai, Chi Sun, Yu-Tsan Lin, Li-Chieh Wang, Hsin-Hui Yu, Yao-Hsu Yang, Chun-An Chen, Kong-Sang Wan, Bor-Luen Chiang
Pediatrics Aug 2014, 134 (2) e397-e405; DOI: 10.1542/peds.2014-0376
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Print
Download PDF
Insight Alerts
  • Table of Contents

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Comments

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Different potencies of topical corticosteroids for a better treatment strategy in children with atopic dermatitis (the Rotterdam Eczema study): protocol for an observational cohort study with an embedded randomised open-label controlled trial
  • Google Scholar

More in this TOC Section

  • Predictive Models of Neurodevelopmental Outcomes After Neonatal Hypoxic-Ischemic Encephalopathy
  • A Technology-Assisted Language Intervention for Children Who Are Deaf or Hard of Hearing: A Randomized Clinical Trial
  • Standard Versus Long Peripheral Catheters for Multiday IV Therapy: A Randomized Controlled Trial
Show more Article

Similar Articles

Subjects

  • Sleep Medicine
    • Sleep Medicine
  • Allergy/Immunology
    • Allergy/Immunology

Keywords

  • sleep disturbance
  • atopic dermatitis
  • actigraphy
  • polysomnography
  • SCORAD
  • melatonin
  • IgE
  • dust mite
  • staphylococcal enterotoxin
  • Journal Info
  • Editorial Board
  • Editorial Policies
  • Overview
  • Licensing Information
  • Authors/Reviewers
  • Author Guidelines
  • Submit My Manuscript
  • Open Access
  • Reviewer Guidelines
  • Librarians
  • Institutional Subscriptions
  • Usage Stats
  • Support
  • Contact Us
  • Subscribe
  • Resources
  • Media Kit
  • About
  • International Access
  • Terms of Use
  • Privacy Statement
  • FAQ
  • AAP.org
  • shopAAP
  • Follow American Academy of Pediatrics on Instagram
  • Visit American Academy of Pediatrics on Facebook
  • Follow American Academy of Pediatrics on Twitter
  • Follow American Academy of Pediatrics on Youtube
  • RSS
American Academy of Pediatrics

© 2021 American Academy of Pediatrics