Skip to main content

Advertising Disclaimer »

Main menu

  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers
  • Other Publications
    • American Academy of Pediatrics

User menu

  • Log in

Search

  • Advanced search
American Academy of Pediatrics

AAP Gateway

Advanced Search

AAP Logo

  • Log in
  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers

Discover Pediatric Collections on COVID-19 and Racism and Its Effects on Pediatric Health

American Academy of Pediatrics
Review Article

Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review

Margaret A. Maglione, Lopamudra Das, Laura Raaen, Alexandria Smith, Ramya Chari, Sydne Newberry, Roberta Shanman, Tanja Perry, Matthew Bidwell Goetz and Courtney Gidengil
Pediatrics August 2014, 134 (2) 325-337; DOI: https://doi.org/10.1542/peds.2014-1079
Margaret A. Maglione
aRAND Corporation, Santa Monica, California;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lopamudra Das
aRAND Corporation, Santa Monica, California;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura Raaen
aRAND Corporation, Santa Monica, California;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexandria Smith
aRAND Corporation, Santa Monica, California;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ramya Chari
aRAND Corporation, Santa Monica, California;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sydne Newberry
aRAND Corporation, Santa Monica, California;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roberta Shanman
aRAND Corporation, Santa Monica, California;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tanja Perry
aRAND Corporation, Santa Monica, California;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew Bidwell Goetz
bVA Greater Los Angeles Healthcare System and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Courtney Gidengil
aRAND Corporation, Santa Monica, California;
cBoston Children’s Hospital, Boston, Massachusetts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Comments
Loading
Download PDF

Abstract

BACKGROUND: Concerns about vaccine safety have led some parents to decline recommended vaccination of their children, leading to the resurgence of diseases. Reassurance of vaccine safety remains critical for population health. This study systematically reviewed the literature on the safety of routine vaccines recommended for children in the United States.

METHODS: Data sources included PubMed, Advisory Committee on Immunization Practices statements, package inserts, existing reviews, manufacturer information packets, and the 2011 Institute of Medicine consensus report on vaccine safety. We augmented the Institute of Medicine report with more recent studies and increased the scope to include more vaccines. Only studies that used active surveillance and had a control mechanism were included. Formulations not used in the United States were excluded. Adverse events and patient and vaccine characteristics were abstracted. Adverse event collection and reporting was evaluated by using the McHarm scale. We were unable to pool results. Strength of evidence was rated as high, moderate, low, or insufficient.

RESULTS: Of 20 478 titles identified, 67 were included. Strength of evidence was high for measles/mumps/rubella (MMR) vaccine and febrile seizures; the varicella vaccine was associated with complications in immunodeficient individuals. There is strong evidence that MMR vaccine is not associated with autism. There is moderate evidence that rotavirus vaccines are associated with intussusception. Limitations of the study include that the majority of studies did not investigate or identify risk factors for AEs; and the severity of AEs was inconsistently reported.

CONCLUSIONS: We found evidence that some vaccines are associated with serious AEs; however, these events are extremely rare and must be weighed against the protective benefits that vaccines provide.

  • evidence-based medicine
  • vaccine/immunization
  • infectious disease
  • Abbreviations:
    AEs —
    adverse events
    AHRQ —
    Agency for Healthcare Research and Quality
    CI —
    confidence interval
    DTaP —
    diphtheria, tetanus, and acellular pertussis
    H1N1 —
    Swine Flu
    Hib —
    Haemophilus influenza type b
    ILI —
    influenza-like illness
    IOM —
    Institute of Medicine
    IPV —
    inactivated poliovirus
    IRR —
    incidence rate ratio
    LAIV —
    live attenuated vaccine
    MMR —
    measles/mumps/rubella
    Oka VZV —
    Oka strain varicella zoster virus
    OR —
    odds ratio
    PCV —
    pneumococcal conjugate vaccine
    PRISM —
    Post-Licensure Rapid Immunization Safety Monitoring
    Td —
    tetanus-diphtheria
    TIV —
    trivalent inactivated vaccine
    VSD —
    Vaccine Safety Datalink
  • Vaccines are considered one of the greatest public health achievements of the 20th century for their role in eradicating smallpox and controlling polio, measles, rubella, and other infectious diseases in the United States.1 Despite their effectiveness in preventing and eradicating disease, routine childhood vaccine uptake remains suboptimal. Parent refusal of vaccines has contributed to outbreaks of vaccine-preventable diseases such as measles2 and pertussis.3 In addition, although multiple large studies have confirmed the lack of association between measles/mumps/rubella (MMR) and autism, parental worries about the safety of vaccines persist.

    The Agency for Healthcare Research and Quality (AHRQ) requested an evidence report on the safety of vaccines recommended for routine immunization of adults (including pregnant women), children, and adolescents to be used by the Office of the Assistant Secretary of Health to identify the gaps in evidence. This article addresses the safety of vaccines recommended for routine use in children aged 6 years and younger: DTaP (diphtheria, tetanus, and acellular pertussis), hepatitis A, hepatitis B, Haemophilus influenza type b (Hib), influenza (live attenuated and inactivated), meningococcal (conjugate or polysaccharide), MMR, pneumococcal (conjugate or polysaccharide), rotavirus, and varicella. It represents the results of a comprehensive and systematic review of scientific evidence, describes statistical associations between vaccines and adverse events (AEs), and reports on any risk factors identified.

    Methods

    In 2011, the Institute of Medicine (IOM) published a consensus report titled Adverse Effects of Vaccines: Evidence and Causality.4 That report evaluated the scientific evidence for AEs potentially associated with varicella, influenza, hepatitis A, hepatitis B, human papillomavirus, MMR, meningococcal, tetanus, diphtheria, and pertussis vaccines. We report the IOM findings regarding children and update those findings by identifying and evaluating studies published after the IOM searches. We also identify studies and evaluate evidence on pneumococcal, rotavirus, Hib, and inactivated poliovirus (IPV) vaccines because these are recommended for children aged 6 years and younger.

    The following databases were searched: DARE (Database of Abstracts of Reviews of Effects), the Cochrane Database of Systematic Reviews, CENTRAL, PubMed, Embase, CINAHL (Cumulative Index to Nursing and Allied Health), TOXLINE (Toxicology Literature Online), and TOXFILE. The IOM report, Advisory Committee on Immunization Practices statements, vaccine package inserts, and review articles were mined for studies. Using the IOM keyword search strategy, we updated their searches to identify more recently published studies. The following structure was used: “vaccine term” AND “health term,” where vaccine terms include the technical vaccine name, general descriptions of the vaccine of interest (eg, rotavirus AND vaccine), or manufacturer names; health terms include a list of AEs potentially associated with the vaccine. We also added more general AE keywords to the list of health terms such as “safe” or “safety,” “side effect” or “harm.” We searched from a year before the publication of the IOM report through August 2013. Using this approach, we developed new search strategies for the vaccines not originally included in the IOM report and searched each database from its inception through August 2013. AE terms were based on AEs reported in systems such as the Vaccine Injury Compensation Program, Vaccine Adverse Event Reporting System, and the Food and Drug Administration’s Mini-Sentinel Program. A Technical Expert Panel reviewed the draft list of AEs and suggested additional AEs of interest.

    We included studies that used active surveillance and had a control mechanism; eligible designs were controlled trials, cohorts comparing a vaccinated with nonvaccinated group, case–control studies, self-controlled case series, and observational studies that used regression to control for confounders and test multiple relationships simultaneously (multivariate risk factor analyses). Common sources of data included medical records, health insurance claims, and government registries.

    To maintain applicability to the current US context, we excluded studies of vaccine formulations never used or no longer available in the United States; examples include whole cell pertussis vaccine, oral polio vaccine, and pneumococcal conjugate vaccine (PCV)7 vaccine. The recent IOM report, The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies,5 makes recommendations for future research on childhood vaccine schedules and cumulative effect, so the current project focused on specific vaccines, rather than any cumulative effect.

    Two researchers experienced in systematic review methodology independently reviewed the titles and abstracts identified. The union of their selections was retrieved. These researchers independently reviewed the full text of study reports and met to reach consensus regarding exclusion/inclusion. Disputes were settled by the lead investigators and team physician experts. Patient and study characteristics were abstracted by single researchers and confirmed by the project leader. If a study reported severity or if adequate information was provided for our investigators to categorize severity, we used the Common Terminology Criteria for Adverse Events classification system6 to characterize AEs. The definition of “serious” differs by AE type; each category of AE (ie fever, headache) is rated on a 5-point scale, with 1 being very mild and 5 being death due to the event.

    The McHarm instrument7 was used to evaluate the quality of the studies with regard to their assessment of AEs. Studies that reported timing and severity and defined AEs using standard, precise definitions were rated higher than those that did not. We assessed the overall strength of evidence by using guidance suggested by AHRQ for its Effective Health Care Program8 as of 2013. (The guidance has since been modified slightly.) The method is based on one developed by the Grading of Recommendations Assessment Working Group9 and classifies the evidence based on risk of bias, consistency, directness, precision, dose–response, plausible confounders that would decrease the observed effect, strength of association, and publication bias. Possible ratings are as follows:

    • High = High confidence that the evidence reflects the true effect. Further research is very unlikely to change our confidence in the estimate of effect.

    • Moderate = Moderate confidence that the evidence reflects the true effect. Further research may change our confidence in the estimate of effect and may change the estimate.

    • Low = Low confidence that the evidence reflects the true effect. Further research is likely to change our confidence in the estimate of effect and is likely to change the estimate.

    • Insufficient = Evidence either is unavailable or does not permit a conclusion.

    It is important to note that the 2011 IOM report used different terminology to classify the strength of evidence; evidence was classified as either “convincingly supports,” “favors acceptance,” “inadequate to accept or reject,” or “favors rejection” of a causal association. They also included mechanistic studies and individual case reports to assess the biological plausibility of AE and considered this in addition to any statistical association. For each vaccine discussed in the IOM report, we started with the IOM findings and modified them, if needed, on the basis of any additional evidence we identified.

    Results

    As presented in Fig 1, 20 478 titles were identified through electronic literature searches; review of product inserts; review of Food and Drug Administration, Advisory Committee on Immunization Practices, and other Web sites; reference mining; and requests for Scientific Information Packets from drug manufacturers. Of those, 17 270 were excluded on review of abstract or title for reasons such as “not about a vaccine,” “vaccine not within the scope of this project” (formulations never available in the United States, recommended only for travel), or because they were animal studies. Upon full text review of the remaining 3208 articles, 392 were identified as relevant background/theoretical materials and set aside as potential references for the Introduction; 2749 other articles were excluded. The most common reason for exclusion was lack of suitable study design (1549): individual case reports, nonsystematic reviews, and studies using passive surveillance were excluded. Many publications (458) discussed vaccines on the recommended schedule but did not report or assess AEs. Eighty-eight studies on adults or adolescents were excluded for this article, as were 11 studies of children with preexisting conditions such as HIV, juvenile arthritis, or cancer, which left 67 studies. These studies are in addition to those included in the 2011 IOM consensus report Adverse Effects of Vaccines: Evidence and Causality, which were not abstracted.

    FIGURE 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1

    Literature diagram.

    We present the results for each vaccine in alphabetical order. Results are summarized in Table 1.

    View this table:
    • View inline
    • View popup
    TABLE 1

    Results: Safety of Vaccines Used for Routine Immunization of Children

    DTaP

    The IOM studied diphtheria toxoid, tetanus toxoid, and acellular pertussis-containing vaccines alone and in combination in both children and adults. The IOM committee did not find evidence that “favors acceptance” of causal relationships for any conditions. They found the evidence “favors rejection” of a causal relationship between type 1 diabetes and vaccines containing diphtheria toxoid, tetanus toxoid, and acellular pertussis antigens.10–14 We found no additional studies in children published after the IOM search date; our review of their assessment supports their conclusions.

    Hib Vaccine

    The IOM did not study the safety of Hib vaccine. We identified 3 controlled trials of the Hib vaccine in children15–17; 1 was set in the United States, the other 2 in Asia. Results of the US trial (N = 5190) indicated that Hib vaccination was associated with redness (odds ratio [OR] 2.71, 95% confidence interval [CI] 1.57–4.67) and swelling (OR 9.44, 95% CI 4.90–18.19) but not with hospitalizations. Vaccination was not associated with high fever in either the US trial or a trial in the Philippines. A trial in Vietnam15 found the vaccine was not associated with any serious AEs, including convulsion, diarrhea, fungal infection, or gastroesophageal reflux disease. No other AEs were associated with the Hib vaccination.

    Hepatitis A

    Hepatitis A vaccine was not covered by the IOM report on vaccine safety. We did not identify any studies of children that assessed the association of hepatitis A alone with AEs. However, we did identify a recent analysis that investigated possible relationships among Hib, PCV, MMR, DTaP, trivalent inactivated vaccine (TIV), hepatitis A, varicella, and meningococcal vaccines and immune thrombocytopenic purpura in children enrolled in 5 US health maintenance organizations.18 Purpura was not associated with any of the vaccines in children aged 2 to 6 years but was associated with vaccination against hepatitis A in children aged 7 to 17 years (incidence rate ratio 23.14, 95% CI 3.59–149.30; findings related to other vaccines are reported in their respective sections). This study provides evidence for a moderate association between hepatitis A vaccine and purpura in children aged 7 to 17 years.

    Hepatitis B

    Although no epidemiologic studies were identified by the IOM, mechanistic evidence “favored acceptance” of a causal relationship between the vaccine and anaphylaxis in yeast-sensitive individuals. The 2011 IOM study found “insufficient” evidence of an association of hepatitis B vaccine with any short- or long-term AEs in children. A 2002 IOM review on hepatitis B vaccine and demyelinating neurologic disorders concluded that the evidence “favors rejection” of a causal relationship with incident multiple sclerosis or multiple sclerosis relapse.19 We identified 1 study published after the IOM 2011 search: Gallagher and Goodman (2010)20 conducted a secondary analysis of National Health Interview Survey data on 7074 boys born before 1999. Vaccination status and health outcomes were reported by parents. Results were significant for the risk of autism in children who received their first dose of hepatitis B vaccine during the first month of life (OR 3.00, 95% CI 1.11–8.13), compared with those who received the vaccination after the first month of life or not at all. Significant protective factors included non-Hispanic white ethnicity (OR 0.36, 95% CI 0.15–0.88) and belonging to a household with 2 parents (OR 0.30, 95% CI 0.12–0.75). It is unclear why the authors selected “first month of life” as the only vaccination time period studied, without presenting analyses for other time periods or comparing “ever vaccinated” with “never vaccinated.” Because of high risk of bias and low quality, this study presents insufficient evidence that hepatitis B vaccine is associated with autism.

    IPV: Inactivated Polio Virus

    The IOM did not study IPV vaccine. Our search identified a case–control study of >2000 children with atopic dermatitis and a family history of allergy in 12 Western countries,21 which found that newborns immunized against polio had higher odds (OR 2.60, 95% CI 1.08–6.25) of sensitivity to food allergens. This relationship did not hold for those immunized against polio later in life. A self-controlled case series of premature infants born in the United States22 found no increased risk of wheezing and lower respiratory syndrome associated with DTaP, IPV, Hib, varicella, PCV7, MMR, or TIV vaccination. In sum, the strength of evidence is insufficient to determine an association between polio vaccine in newborns and sensitivity to food allergens.

    Influenza Vaccines

    Influenza vaccine is administered in 2 forms: live attenuated vaccine (LAIV), administered intranasally, and TIV, administered intramuscularly. The IOM found no evidence that “convincingly supports” causal relationships in the pediatric population for any AEs. We identified 1 trial of seasonal influenza vaccine (which included a strain of H1N1 [swine flu])23 and 1 cohort comparison study of 2009 monovalent H1N1 vaccine24 published after the IOM search dates; the studies found no evidence of an association of the vaccines with AEs.

    Six observational studies also met our inclusion criteria.25–30 A 2011 UK study of 2336 children25 found no association between flu vaccines and febrile seizures; however, a recent study using the US Vaccine Safety Datalink (VSD)26 found an association of flu vaccine with febrile seizures, which increased with concomitant administration of pneumococcal vaccine (PCV13). In the highest risk age group (16 months), estimated rate was 12.5 per 100 000 doses for TIV without concomitant PCV13, 13.7 per 100 000 doses for PCV13 without concomitant TIV, and 44.9 per 100 000 doses for concomitant TIV and PCV13. In large, high-quality postlicensure studies, both LAIV and TIV were associated with mild gastrointestinal disorders,27,28 such as short-term vomiting and diarrhea in children. Strength of evidence is moderate for these AEs. One of these studies found that younger vaccinated children (aged 5–8 years) were more likely to experience these symptoms than older vaccinated children (aged 9–17 years). (Children <5 years of age were not included in that study). Finally, an Italian study31 of children hospitalized for influenza-like illness (ILI) found those vaccinated with seasonal vaccine (OR 2.1, 95% CI 1.1–4.1) were significantly more likely to show symptoms of ILI than unvaccinated children, whereas those vaccinated for H1N1 were not at higher risk (OR 1.3, 95% CI 0.6–3.1). Strength of evidence is moderate for mild gastrointestinal events and febrile seizures and low for ILI.

    MMR

    The IOM committee found that mechanistic evidence “convincingly supports” causal relationships between MMR and measles inclusion body encephalitis in immunocompromised children and anaphylaxis in allergic patients. They also found epidemiologic evidence that “convincingly supports” a causal relationship between MMR vaccine and febrile seizures.32–38 The IOM committee found the evidence “favors acceptance” of a causal relationship between MMR and transient arthralgia in the pediatric population.39–45 They found the evidence “favors rejection” of a causal relationship between MMR and autism.46–50 In addition, a causal relationship between the Urabe strain of mumps and aseptic meningitis has been shown; there is no evidence to link Jeryl Lynn strain, commonly used in the United States, to this AE.

    We identified 5 postlicensure studies of childhood MMR vaccination published after the IOM searches. In a case–control study of 189 young adults with autism spectrum disorder and 224 controls, Uno et al51 found that childhood receipt of MMR vaccine was not associated with an increased rate of new-onset autism (OR 1.10, 95% CI 0.64–1.90). In 3 studies,18,52,53 MMR vaccination was associated with thrombocytopenic purpura in children in the short term after vaccination. Strength of evidence is moderate because findings were consistent and ORs similar in 3 European countries, Canada, and the United States. Finally, 1 Canadian study found MMR vaccination was associated with increased emergency department visits within 2 weeks. This finding is consistent with the IOM’s findings that MMR vaccine is associated with febrile seizures.

    Meningococcal

    The IOM found the evidence “convincingly supports” a causal relationship with anaphylaxis in children who may be allergic to ingredients. The IOM conclusion does not differentiate between meningococcal conjugate or meningococcal polysaccharide vaccines. We found 2 studies of quadrivalent meningococcal conjugate vaccine in children54,55 published after the IOM report. A trial in Saudi Arabia found no statistical association with grade 2 or 3 fever, malaise, myalgia, or headache in the short term.54 A trial in the United States and South America55 found vaccination was not associated with severe change in eating habits, severe irritability, severe persistent crying, severe sleepiness, or urticaria in the year after vaccination.

    Thus, the strength of evidence is moderate that meningococcal vaccine may cause anaphylaxis in children who are allergic to ingredients. Strength of evidence is insufficient to determine an association with less serious events such as headache, irritability, and urticaria.

    PCV13

    The IOM did not study the safety of PCV13. As noted earlier, the VSD26 analyzed data on >200 000 US children aged <5 years and found that vaccine against pneumonia (PCV13) was associated with febrile seizures; importantly, administration of influenza vaccine at the same visit was associated with increased risk. For example, in the highest risk group, which was 16-month-old children, the estimated rate was 13.7 per 100 000 doses for PCV13 without concomitant TIV and 44.9 per 100 000 doses for concomitant TIV and PCV13. Risk difference estimates varied by age due to the varying baseline risk for seizures in young children. Thus the strength of evidence for an association between PCV13 and febrile seizures is moderate, and the risk is particularly high when coadministered with influenza vaccine.

    Rotavirus Vaccines: RotaTeq and Rotarix

    The IOM report did not address vaccines against rotavirus. Thirty-one trials of rotavirus vaccine56–85 met our inclusion criteria. Participants in the accepted studies received 2 or 3 oral-administered doses of Rotarix (18 studies) or RotaTeq (13 studies). Neither Rotarix nor RotaTeq was associated with increased risk of AEs other than cough, runny nose, or irritability.

    We identified 5 postlicensure studies on intussusception risk86–90; an earlier brand of rotavirus vaccine (Rotashield) was withdrawn from the market in 1999 due to concerns about risk for this condition. A high-quality epidemiologic study (N = 296 023) conducted in Australia86 found RotaTeq associated with intussusception in children 1 to 21 days after the first of 3 required doses but found no association with Rotarix. Two postlicensure studies were recently conducted in the United States. Shui et al89 analyzed VSD data on 786 725 doses of RotaTeq and found no association with intussusception at any time after vaccination. However, a recent analysis of data from the US Post-Licensure Rapid Immunization Safety Monitoring (PRISM) program90 found that intussusception risk was increased after Dose 1 of RotaTeq and Dose 2 of Rotarix. The RotaTeq analysis had higher statistical power because that vaccine was administered to orders of magnitude more children than Rotarix. Estimated rate of intussusception was 1.1 to 1.5 cases per 100 000 doses of RotaTeq and 5.1 cases per 100 000 doses of Rotarix.

    In addition, 2 case–control studies conducted in Latin America found an association with intussusception in children after the first of 2 required doses of Rotarix. One study estimated Rotarix increased risk by 3.7 additional cases per 100 000 person years in Mexico.87 The other Latin American study estimated risk as 1 case per 51 000 vaccinations in Mexico and 1 case per 68 000 vaccinations in Brazil.88 In sum, there is moderate strength evidence that vaccination against rotavirus is associated with intussusception, but the occurrence is extremely rare, and risk factors have not been investigated.

    Varicella

    The IOM committee found evidence “convincingly supports” causal relationships in children between varicella virus vaccine and the following: disseminated Oka strain varicella zoster virus (Oka VZV) without other organ involvement; disseminated Oka VZV with subsequent infection resulting in pneumonia,91 meningitis, or hepatitis in individuals with demonstrated immunodeficiencies; vaccine strain viral reactivation without other organ involvement; vaccine strain viral reactivation with subsequent infection resulting in meningitis or encephalitis92; and anaphylaxis.91

    We identified 1 study that investigated possible relationships among Hib, PCV, MMR, DTaP, TIV, hepatitis A, varicella, and meningococcal vaccines and immune thrombocytopenic purpura in children enrolled in 5 US health maintenance organizations.18 Purpura was not associated with any of the vaccines in children aged 2 to 6 years but was associated with vaccination against varicella in children aged 11 to 17 years (incidence rate ratio R 12.14, 95% CI 1.10–133.96; findings related to other vaccines are reported in their respective sections). This study provides evidence for a moderate association between varicella vaccine and purpura in children aged 11 to 17 years.

    Studies Controlling for Multiple Vaccinations During Childhood

    Four high-quality epidemiologic studies investigated the potential relationship between vaccinations and onset of childhood leukemia. Groves and colleagues93 included 439 US children with lymphoblastic leukemia in a case–control analysis to investigate any possible relationship with oral or injected polio vaccine, diphtheria-tetanus pertussis vaccine, MMR, Hib, or hepatitis B vaccine. Controls were selected using random-digit dialing, which resulted in controls of higher socioeconomic status then the 439 cases. None of the vaccines were associated with leukemia. The relationship between vaccination and leukemia was also assessed in a case–control study of children in Northern California.94 Cases were matched on date of birth, gender, and race/ethnicity. Analysis also controlled for maternal education and family income. None of the vaccines investigated (DPT, polio vaccine, MMR, Hib, hepatitis B vaccine) were associated with increased risk of leukemia. Similarly, the Cross-Canada Childhood Leukemia Study95 found no association between vaccines against mumps, measles, rubella, diphtheria, tetanus, pertussis, polio, or hepatitis B and leukemia. Finally, a large case–control study of children born in Texas96 found that several vaccines may have a protective effect against acute lymphoblastic leukemia.

    Discussion

    This study updated the evidence presented in the 2011 IOM report and expanded the scope of that study by including additional vaccines such as those against Hib, hepatitis A, PCV13, rotavirus, and IPV. Findings related to these vaccines indicate that the Hib vaccine is associated with local discomfort such as redness and swelling but is not associated with serious AEs or hospitalization. Strength of evidence is moderate for the following associations: Hepatitis A vaccine and purpura in children aged 7 to 17 years, PCV13 and febrile seizures with an escalation of risk when coadministered with TIV, and rotavirus vaccine and intussusception. None of the vaccines studied here were associated with childhood-onset leukemia.

    Our findings support the following IOM results: vaccine against hepatitis B is not associated with any long- or short-term AEs; the MMR vaccine is associated with febrile seizures; MMR vaccine is not associated with autism. In addition, our study found moderate evidence linking both LAIV and TIV forms of the influenza vaccines with mild gastrointestinal events; TIV was associated with febrile seizures. We also found moderate (but consistent) strength evidence of an association between the MMR vaccine and thrombocytopenic purpura in children; there was a similar association between the varicella vaccine and thrombocytopenic purpura in children aged 11 to 17 years.

    Literature search procedures for this review were extensive; however, some unpublished trial results may not have been identified. An independent Scientific Resource Center under contract with AHRQ requested Scientific Information Packets from the vaccine manufacturers. (The research team was prohibited from contacting manufacturers directly.) Only 2 companies responded.

    Our findings are based on only the most rigorous study designs to assess potential statistical associations; however, these designs have limitations that must be considered. Controlled trials often have insufficient sample size to identify rare AEs and do not have extended follow-up to identify long-term sequelae. In addition, trials may purposely exclude subjects who could be more susceptible to AEs. For this reason, any comprehensive review of vaccine safety must include postlicensure studies, but these also have limitations. Large epidemiologic studies sometimes include any available formulation of vaccines against a particular disease and may not stratify results by dosage or formulation. For example, the relationship between the “seasonal influenza vaccine” and an AE could be studied over several years of data without considering the changes in formulation over the seasons or differentiating between live or inactive vaccine. In addition, people who avoid vaccinations (whether purposely or not) may differ from those who receive vaccinations in terms of race, gender, age, socioeconomic status, and preexisting medical conditions, and these differences may be associated with health outcomes. Observational studies may attempt to control for such potential confounders by using matched cohorts or multivariate regression analysis; still, some factors such as environmental exposures may be unmeasured or challenging to adequately control for.

    The self-controlled case series was developed specifically to assess the safety of vaccines; this method eliminates confounding by all time-independent variables by using cases as their own controls and predefined “time windows” before and after vaccination. This design has been used to study purpura, febrile seizures, intussusception, and autism in children. However, the assumption of no temporal shifts in this model is difficult to justify in very young children because any patient characteristics that change with time will not be adequately controlled for.

    Importantly, some AE signals that warrant future research may not have been identified by this project. Passive surveillance systems such as the US Vaccine Adverse Event Reporting System97 are crucial in identifying signals regarding AEs post licensure, but they are not designed to assess a statistical association, so they were excluded as sources of data.

    Conclusions

    Our findings may allay some patient, caregiver, and health care provider concerns. Strength of evidence is high that MMR vaccine is not associated with the onset of autism in children; this conclusion supports findings of all previous reviews on the topic. There is also high-strength evidence that MMR, DTaP, Td, Hib, and hepatitis B vaccines are not associated with childhood leukemia.

    Evidence was found for an association of several serious AEs with vaccines; however, these events were extremely rare: absolute risk is low. For example, strength of evidence is moderate for association of vaccines against rotavirus with intussusception. Although 1 large US epidemiologic study found no association, a recent analysis of the US PRISM program90 found both RotaTeq and Rotarix associated with intussusception in the short term. Estimated rates were 1.1 to 1.5 cases per 100 000 doses of RotaTeq and 5.1 cases per 100 000 doses of Rotarix.

    Few studies were powered to detect patient characteristics associated with increased risk of rare AEs. Advanced health information technology systems that contain both vaccination and health outcome records may be used to conduct such investigations. In the United States, the VSD contains data from such systems at 9 large managed care organizations. In addition, the PRISM program also conducts active surveillance using electronic health care databases from managed care organizations. Nations with single-payer health care systems often have electronic registries that allow large epidemiologic studies of entire populations. Future analyses should be stratified by formulation and brand of vaccine whenever possible.

    Acknowledgments

    The authors thank Aneesa Motala, BA, for compiling the many peer review comments and formatting the final report. We thank Susanne Hempel, PhD, for her advice on study design, Paul Shekelle, MD, PhD, for his advice and review of the draft and final versions of the evidence report, Kim Wittenberg, MA, for serving as the AHRQ Task Order Officer and Steve Bende, PhD, for representing the Office of the Assistant Secretary for Health. We thank the following individuals for serving on the Technical Expert Panel for the project: Meghan Baker, MD ScD; Richard Beigi, MD, MSc; Kathryn Edwards, MD; Kristen Feemster, MD, MSPH; Bruce Fireman, MA; David Martin, MD; and Claudia Vellozzi, MD, MPH. Finally, we would like to thank the following Peer Reviewers: Janet D. Cragan, MD, MPH; Francesca Cunningham, Pharm D; Frank Destefano, MD, MPH; and Laura Elizabeth Riley, MD. Please note that service as a Peer Reviewer or Expert Panel member does not imply endorsement of the study findings.

    Footnotes

      • Accepted May 7, 2014.
    • Address correspondence to Margaret A. Maglione, MPP, RAND Corporation, 1776 Main St Mailstop 4W, Santa Monica, CA 90407. E-mail: maglione{at}rand.org
    • Ms Maglione conceptualized and designed the study, oversaw the abstraction of data, interpreted the results, and drafted the manuscript; Ms Das abstracted data, interpreted results, and revised the manuscript; Ms Raaen abstracted data, interpreted results, and revised the manuscript; Ms Smith designed data collection instruments, analyzed data, and revised the manuscript; Dr Chari abstracted data, interpreted results, and revised the manuscript; Dr Newberry revised the manuscript for important content and approved the final manuscript as submitted; Ms Shanman developed the literature search strategy, conducted electronic literature searches, and acquired data; Ms Perry acquired data and designed screening and data abstraction forms; Dr Goetz contributed to the conceptualization and design of the study, interpreted results, and critically reviewed and revised the manuscript; Dr Gidengil participated in study design, interpreted the results, drafted part of the manuscript, and critically reviewed the manuscript, and all authors approved the final manuscript as submitted.

    • The authors of this report are responsible for its content. Statements in the report should not be construed as endorsement by the Agency for Healthcare Research and Quality or the US Department of Health and Human Services.

    • FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.

    • FUNDING: Supported under Contract No. HHSA290200710062I from the Agency for Healthcare Research and Quality, US Department of Health and Human Services.

    • POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

    • COMPANION PAPER: A companion to this article can be found on page 377, and online at www.pediatrics.org/cgi/doi/10.1542/peds.2014-1494.

    References

    1. ↵
      1. Centers for Disease Control and Prevention (CDC)
      . Ten great public health achievements—United States, 1900–1999. MMWR Morb Mortal Wkly Rep. 1999;48(12):241–243pmid:10220250
      OpenUrlPubMed
    2. ↵
      1. Sugerman DE,
      2. Barskey AE,
      3. Delea MG,
      4. et al
      . Measles outbreak in a highly vaccinated population, San Diego, 2008: role of the intentionally undervaccinated. Pediatrics. 2010;125(4):747–755pmid:20308208
      OpenUrlAbstract/FREE Full Text
    3. ↵
      1. Atwell JE,
      2. Van Otterloo J,
      3. Zipprich J,
      4. et al
      . Nonmedical vaccine exemptions and pertussis in California, 2010. Pediatrics. 2013;132(4):624–630pmid:24082000
      OpenUrlAbstract/FREE Full Text
    4. ↵
      1. Institute of Medicine
      . Adverse Effects of Vaccines: Evidence and Causality. Washington, DC: The National Academy Press; 2011
    5. ↵
      1. Castro M,
      2. Dozor A,
      3. Fish J,
      4. et al
      . The safety of inactivated influenza vaccine in adults and children with asthma. N Engl J Med. 2001;345(21):1529–1536pmid:11794219
      OpenUrlCrossRefPubMed
    6. ↵
      US Department of Health and Human Services. Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0. May 28, 2009 (v4.03: June 14, 2010)
    7. ↵
      Santaguida PL, Raina P. The Development of the McHarm Quality Assessment Scale for adverse events: Delphi Consensus on important criteria for evaluating harms. 2008. Available at: http://hiru.mcmaster.ca/epc/mcharm.pdf. Accessed May 5, 2012
    8. ↵
      1. Owens DK,
      2. Lohr KN,
      3. Atkins D,
      4. et al
      . AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions—agency for healthcare research and quality and the effective health-care program. J Clin Epidemiol. 2010;63(5):513–523pmid:19595577
      OpenUrlCrossRefPubMed
    9. ↵
      1. Balshem H,
      2. Helfand M,
      3. Schünemann HJ,
      4. et al
      . GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64(4):401–406pmid:21208779
      OpenUrlCrossRefPubMed
    10. ↵
      1. Blom L,
      2. Nyström L,
      3. Dahlquist G
      . The Swedish childhood diabetes study. Vaccinations and infections as risk determinants for diabetes in childhood. Diabetologia. 1991;34(3):176–181pmid:1884889
      OpenUrlCrossRefPubMed
      1. DeStefano F,
      2. Mullooly JP,
      3. Okoro CA,
      4. et al.,
      5. Vaccine Safety Datalink Team
      . Childhood vaccinations, vaccination timing, and risk of type 1 diabetes mellitus. Pediatrics. 2001;108(6):E112pmid:11731639
      OpenUrlCrossRefPubMed
      1. Hviid A,
      2. Stellfeld M,
      3. Wohlfahrt J,
      4. Melbye M
      . Childhood vaccination and type 1 diabetes. N Engl J Med. 2004;350(14):1398–1404pmid:15070789
      OpenUrlCrossRefPubMed
      1. Klein NP,
      2. Hansen J,
      3. Lewis E,
      4. et al
      . Post-marketing safety evaluation of a tetanus toxoid, reduced diphtheria toxoid and 3-component acellular pertussis vaccine administered to a cohort of adolescents in a United States health maintenance organization. Pediatr Infect Dis J. 2010;29(7):613–617pmid:20190673
      OpenUrlCrossRefPubMed
    11. ↵
      Infections and vaccinations as risk factors for childhood type I (insulin-dependent) diabetes mellitus: a multicentre case–control investigation. EURODIAB Substudy 2 Study Group. Diabetologia. 2000;43(1):47–53pmid:10663215
      OpenUrlCrossRefPubMed
    12. ↵
      1. Huu TN,
      2. Toan NT,
      3. Tuan HM,
      4. et al
      . Safety and reactogenicity of primary vaccination with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine in Vietnamese infants: a randomised, controlled trial. BMC Infect Dis. 2013;13:95pmid:23432812
      OpenUrlCrossRefPubMed
      1. Santosham M,
      2. Wolff M,
      3. Reid R,
      4. et al
      . The efficacy in Navajo infants of a conjugate vaccine consisting of Haemophilus influenzae type b polysaccharide and Neisseria meningitidis outer-membrane protein complex. N Engl J Med. 1991;324(25):1767–1772pmid:1903846
      OpenUrlCrossRefPubMed
    13. ↵
      Capeding MRZ, Nohynek H, Pascual LG, et al. The immunogenicity of three Haemophilus influenzae type B conjugate vaccines after a primary vaccination series in Philippine infants. Am J Trop Med Hygiene. 1996;55(5):516–520
    14. ↵
      1. O’Leary ST,
      2. Glanz JM,
      3. McClure DL,
      4. et al
      . The risk of immune thrombocytopenic purpura after vaccination in children and adolescents. Pediatrics. 2012;129(2):248–255pmid:22232308
      OpenUrlAbstract/FREE Full Text
    15. ↵
      Institute of Medicine. Immunization Safety Review: Multiple Immunizations and Immune Dysfunction. Washington, DC: The National Academies Press; 2002
    16. ↵
      Gallagher CM, Goodman MS. Hepatitis B vaccination of male neonates and autism diagnosis, NHIS 1997–2002. J Toxicol Environ Health A. 2010;73(24):1665–1677
    17. ↵
      1. Grüber C,
      2. Warner J,
      3. Hill D,
      4. Bauchau V,
      5. EPAAC Study Group
      . Early atopic disease and early childhood immunization—is there a link? Allergy. 2008;63(11):1464–1472pmid:18925883
      OpenUrlCrossRefPubMed
    18. ↵
      1. Mullooly JP,
      2. Schuler R,
      3. Barrett M,
      4. Maher JE
      . Vaccines, antibiotics, and atopy. Pharmacoepidemiol Drug Saf. 2007;16(3):275–288pmid:16794993
      OpenUrlCrossRefPubMed
    19. ↵
      1. Englund JA,
      2. Walter E,
      3. Black S,
      4. et al.,
      5. GRC28 Study Team
      . Safety and immunogenicity of trivalent inactivated influenza vaccine in infants: a randomized double-blind placebo-controlled study. Pediatr Infect Dis J. 2010;29(2):105–110pmid:19934787
      OpenUrlCrossRefPubMed
    20. ↵
      1. Mallory RM,
      2. Malkin E,
      3. Ambrose CS,
      4. et al
      . Safety and immunogenicity following administration of a live, attenuated monovalent 2009 H1N1 influenza vaccine to children and adults in two randomized controlled trials. PLoS ONE. 2010;5(10):e13755 pmid:21060780
      OpenUrlCrossRefPubMed
    21. ↵
      1. Stowe J,
      2. Andrews N,
      3. Bryan P,
      4. Seabroke S,
      5. Miller E
      . Risk of convulsions in children after monovalent H1N1 (2009) and trivalent influenza vaccines: a database study. Vaccine. 2011;29(51):9467–9472pmid:22019757
      OpenUrlCrossRefPubMed
    22. ↵
      1. Tse A,
      2. Tseng HF,
      3. Greene SK,
      4. Vellozzi C,
      5. Lee GM,
      6. VSD Rapid Cycle Analysis Influenza Working Group
      . Signal identification and evaluation for risk of febrile seizures in children following trivalent inactivated influenza vaccine in the Vaccine Safety Datalink Project, 2010–2011. Vaccine. 2012;30(11):2024–2031pmid:22361304
      OpenUrlCrossRefPubMed
    23. ↵
      1. Baxter R,
      2. Toback SL,
      3. Sifakis F,
      4. et al
      . A postmarketing evaluation of the safety of Ann Arbor strain live attenuated influenza vaccine in children 5 through 17 years of age. Vaccine. 2012;30(19):2989–2998pmid:22386746
      OpenUrlCrossRefPubMed
    24. ↵
      1. Glanz JM,
      2. Newcomer SR,
      3. Hambidge SJ,
      4. et al
      . Safety of trivalent inactivated influenza vaccine in children aged 24 to 59 months in the vaccine safety datalink. Arch Pediatr Adolesc Med. 2011;165(8):749–755pmid:21810637
      OpenUrlCrossRefPubMed
      1. Morgan TM,
      2. Schlegel C,
      3. Edwards KM,
      4. et al.,
      5. Urea Cycle Disorders Consortium
      . Vaccines are not associated with metabolic events in children with urea cycle disorders. Pediatrics. 2011;127(5). Available at: www.pediatrics.org/cgi/content/full/127/5/e1147pmid:21482610
      OpenUrlAbstract/FREE Full Text
    25. ↵
      1. Hambidge SJ,
      2. Ross C,
      3. McClure D,
      4. Glanz J,
      5. VSD team
      . Trivalent inactivated influenza vaccine is not associated with sickle cell hospitalizations in adults from a large cohort. Vaccine. 2011;29(46):8179–8181pmid:21930176
      OpenUrlCrossRefPubMed
    26. ↵
      1. Italian Multicenter Study Group for Drug and Vaccine Safety in Children
      . Effectiveness and safety of the A-H1N1 vaccine in children: a hospital-based case–control study. BMJ Open. 2011;1(2):e000167pmid:22021877
      OpenUrlAbstract/FREE Full Text
    27. ↵
      1. Barlow WE,
      2. Davis RL,
      3. Glasser JW,
      4. et al.,
      5. Centers for Disease Control and Prevention Vaccine Safety Datalink Working Group
      . The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine. N Engl J Med. 2001;345(9):656–661pmid:11547719
      OpenUrlCrossRefPubMed
      1. Chen RT,
      2. Glasser JW,
      3. Rhodes PH,
      4. et al.,
      5. The Vaccine Safety Datalink Team
      . Vaccine Safety Datalink project: a new tool for improving vaccine safety monitoring in the United States. Pediatrics. 1997;99(6):765–773pmid:9164767
      OpenUrlAbstract/FREE Full Text
      1. Farrington P,
      2. Pugh S,
      3. Colville A,
      4. et al
      . A new method for active surveillance of adverse events from diphtheria/tetanus/pertussis and measles/mumps/rubella vaccines. Lancet. 1995;345(8949):567–569pmid:7619183
      OpenUrlCrossRefPubMed
      1. Griffin MR,
      2. Ray WA,
      3. Mortimer EA,
      4. Fenichel GM,
      5. Schaffner W
      . Risk of seizures after measles-mumps-rubella immunization. Pediatrics. 1991;88(5):881–885pmid:1945626
      OpenUrlAbstract/FREE Full Text
      1. Miller E,
      2. Andrews N,
      3. Stowe J,
      4. Grant A,
      5. Waight P,
      6. Taylor B
      . Risks of convulsion and aseptic meningitis following measles-mumps-rubella vaccination in the United Kingdom. Am J Epidemiol. 2007;165(6):704–709pmid:17204517
      OpenUrlAbstract/FREE Full Text
      1. Vestergaard M,
      2. Hviid A,
      3. Madsen KM,
      4. et al
      . MMR vaccination and febrile seizures: evaluation of susceptible subgroups and long-term prognosis. JAMA. 2004;292(3):351–357pmid:15265850
      OpenUrlCrossRefPubMed
    28. ↵
      1. Ward KN,
      2. Bryant NJ,
      3. Andrews NJ,
      4. et al
      . Risk of serious neurologic disease after immunization of young children in Britain and Ireland. Pediatrics. 2007;120(2):314–321pmid:17671057
      OpenUrlAbstract/FREE Full Text
    29. ↵
      1. Benjamin CM,
      2. Chew GC,
      3. Silman AJ
      . Joint and limb symptoms in children after immunisation with measles, mumps, and rubella vaccine. BMJ. 1992;304(6834):1075–1078pmid:1586818
      OpenUrlAbstract/FREE Full Text
      1. Davis RL,
      2. Marcuse E,
      3. Black S,
      4. et al.,
      5. The Vaccine Safety Datalink Team
      . MMR2 immunization at 4 to 5 years and 10 to 12 years of age: a comparison of adverse clinical events after immunization in the Vaccine Safety Datalink project. Pediatrics. 1997;100(5):767–771pmid:9346975
      OpenUrlAbstract/FREE Full Text
      1. Dos Santos BA,
      2. Ranieri TS,
      3. Bercini M,
      4. et al
      . An evaluation of the adverse reaction potential of three measles-mumps-rubella combination vaccines. Rev Panam Salud Publica. 2002;12(4):240–246pmid:12431355
      OpenUrlPubMed
      1. Heijstek MW,
      2. Pileggi GC,
      3. Zonneveld-Huijssoon E,
      4. et al
      . Safety of measles, mumps and rubella vaccination in juvenile idiopathic arthritis. Ann Rheum Dis. 2007;66(10):1384–1387pmid:17284544
      OpenUrlAbstract/FREE Full Text
      1. LeBaron CW,
      2. Bi D,
      3. Sullivan BJ,
      4. Beck C,
      5. Gargiullo P
      . Evaluation of potentially common adverse events associated with the first and second doses of measles-mumps-rubella vaccine. Pediatrics. 2006;118(4):1422–1430pmid:17015532
      OpenUrlAbstract/FREE Full Text
      1. Peltola H,
      2. Heinonen OP
      . Frequency of true adverse reactions to measles-mumps-rubella vaccine. A double-blind placebo-controlled trial in twins. Lancet. 1986;1(8487):939–942pmid:2871241
      OpenUrlPubMed
    30. ↵
      1. Virtanen M,
      2. Peltola H,
      3. Paunio M,
      4. Heinonen OP
      . Day-to-day reactogenicity and the healthy vaccinee effect of measles-mumps-rubella vaccination. Pediatrics. 2000;106(5). Available at: www.pediatrics.org/cgi/content/full/106/5/e62pmid:11061799
      OpenUrlAbstract/FREE Full Text
    31. ↵
      1. Farrington CP,
      2. Miller E,
      3. Taylor B
      . MMR and autism: further evidence against a causal association. Vaccine. 2001;19(27):3632–3635pmid:11395196
      OpenUrlCrossRefPubMed
      1. Madsen KM,
      2. Hviid A,
      3. Vestergaard M,
      4. et al
      . A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med. 2002;347(19):1477–1482pmid:12421889
      OpenUrlCrossRefPubMed
      1. Mrozek-Budzyn D,
      2. Kiełtyka A,
      3. Majewska R
      . Lack of association between measles-mumps-rubella vaccination and autism in children: a case-control study. Pediatr Infect Dis J. 2010;29(5):397–400pmid:19952979
      OpenUrlCrossRefPubMed
      1. Smeeth L,
      2. Cook C,
      3. Fombonne E,
      4. et al
      . MMR vaccination and pervasive developmental disorders: a case-control study. Lancet. 2004;364(9438):963–969pmid:15364187
      OpenUrlCrossRefPubMed
    32. ↵
      1. Taylor B,
      2. Miller E,
      3. Farrington CP,
      4. et al
      . Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet. 1999;353(9169):2026–2029pmid:10376617
      OpenUrlCrossRefPubMed
    33. ↵
      1. Uno Y,
      2. Uchiyama T,
      3. Kurosawa M,
      4. Aleksic B,
      5. Ozaki N
      . The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: the first case–control study in Asia. Vaccine. 2012;30(28):4292–4298pmid:22521285
      OpenUrlCrossRefPubMed
    34. ↵
      1. Andrews N,
      2. Stowe J,
      3. Miller E,
      4. et al.,
      5. VAESCO consortium
      . A collaborative approach to investigating the risk of thrombocytopenic purpura after measles-mumps-rubella vaccination in England and Denmark. Vaccine. 2012;30(19):3042–3046pmid:21699947
      OpenUrlCrossRefPubMed
    35. ↵
      1. Bertuola F,
      2. Morando C,
      3. Menniti-Ippolito F,
      4. et al
      . Association between drug and vaccine use and acute immune thrombocytopenia in childhood: a case–control study in Italy. Drug Saf. 2010;33(1):65–72pmid:20000868
      OpenUrlCrossRefPubMed
    36. ↵
      1. Khalil M,
      2. Al-Mazrou Y,
      3. Findlow H,
      4. et al
      . Safety and immunogenicity of a meningococcal quadrivalent conjugate vaccine in five- to eight-year-old Saudi Arabian children previously vaccinated with two doses of a meningococcal quadrivalent polysaccharide vaccine. Clin Vaccine Immunol. 2012;19(10):1561–1566pmid:22855388
      OpenUrlAbstract/FREE Full Text
    37. ↵
      1. Klein NP,
      2. Reisinger KS,
      3. Johnston W,
      4. et al
      . Safety and immunogenicity of a novel quadrivalent meningococcal CRM-conjugate vaccine given concomitantly with routine vaccinations in infants [published correction appears in Pediatr Infect Dis J. 2012;31(10):1105]. Pediatr Infect Dis J. 2012;31(1):64–71pmid:22094635
      OpenUrlCrossRefPubMed
    38. ↵
      1. Block SL,
      2. Vesikari T,
      3. Goveia MG,
      4. et al.,
      5. Pentavalent Rotavirus Vaccine Dose Confirmation Efficacy Study Group
      . Efficacy, immunogenicity, and safety of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine at the end of shelf life. Pediatrics. 2007;119(1):11–18pmid:17200266
      OpenUrlAbstract/FREE Full Text
      1. Chang C-C,
      2. Chang M-H,
      3. Lin T-Y,
      4. Lee H-C,
      5. Hsieh W-S,
      6. Lee P-I
      . Experience of pentavalent human-bovine reassortant rotavirus vaccine among healthy infants in Taiwan. J Formos Med Assoc. 2009;108(4):280–285pmid:19369174
      OpenUrlCrossRefPubMed
      1. Christie CDC,
      2. Duncan ND,
      3. Thame KA,
      4. et al
      . Pentavalent rotavirus vaccine in developing countries: safety and health care resource utilization. Pediatrics. 2010;126(6). Available at: www.pediatrics.org/cgi/content/full/126/6/e1499pmid:21115586
      OpenUrlAbstract/FREE Full Text
      1. Dennehy PH,
      2. Brady RC,
      3. Halperin SA,
      4. et al.,
      5. North American Human Rotavirus Vaccine Study Group
      . Comparative evaluation of safety and immunogenicity of two dosages of an oral live attenuated human rotavirus vaccine. Pediatr Infect Dis J. 2005;24(6):481–488pmid:15933555
      OpenUrlCrossRefPubMed
      1. Goveia MG,
      2. Rodriguez ZM,
      3. Dallas MJ,
      4. et al.,
      5. REST Study Team
      . Safety and efficacy of the pentavalent human-bovine (WC3) reassortant rotavirus vaccine in healthy premature infants. Pediatr Infect Dis J. 2007;26(12):1099–1104pmid:18043445
      OpenUrlCrossRefPubMed
      1. Grant LR,
      2. Watt JP,
      3. Weatherholtz RC,
      4. et al
      . Efficacy of a pentavalent human-bovine reassortant rotavirus vaccine against rotavirus gastroenteritis among American Indian children. Pediatr Infect Dis J. 2012;31(2):184–188pmid:22252206
      OpenUrlCrossRefPubMed
    39. Kawamura N, Tokoeda Y, Oshima M, et al. Efficacy, safety and immunogenicity of RIX4414 in Japanese infants during the first two years of life. Vaccine. 2011;29(37):6335–6341
      1. Kerdpanich A,
      2. Chokephaibulkit K,
      3. Watanaveeradej V,
      4. et al
      . Immunogenicity of a live-attenuated human rotavirus RIX4414 vaccine with or without buffering agent. Hum Vaccin. 2010;6(3):254–262pmid:20220306
      OpenUrlCrossRefPubMed
      1. Kim DS,
      2. Lee TJ,
      3. Kang JH,
      4. et al
      . Immunogenicity and safety of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine in healthy infants in Korea. Pediatr Infect Dis J. 2008;27(2):177–178pmid:18174862
      OpenUrlPubMed
      1. Kim JS,
      2. Bae CW,
      3. Lee KY,
      4. et al
      . Immunogenicity, reactogenicity and safety of a human rotavirus vaccine (RIX4414) in Korean infants: a randomized, double-blind, placebo-controlled, phase IV study. Hum Vaccin Immunother. 2012;8(6):806–812pmid:22699440
      OpenUrlCrossRefPubMed
      1. Madhi SA,
      2. Cunliffe NA,
      3. Steele D,
      4. et al
      . Effect of human rotavirus vaccine on severe diarrhea in African infants. N Engl J Med. 2010;362(4):289–298pmid:20107214
      OpenUrlCrossRefPubMed
      1. Narang A,
      2. Bose A,
      3. Pandit AN,
      4. et al
      . Immunogenicity, reactogenicity and safety of human rotavirus vaccine (RIX4414) in Indian infants. Hum Vaccin. 2009;5(6):414–419pmid:19276664
      OpenUrlCrossRefPubMed
      1. Omenaca F,
      2. Sarlangue J,
      3. Szenborn L,
      4. et al.,
      5. ROTA-054 Study Group
      . Safety, reactogenicity and immunogenicity of the human rotavirus vaccine in preterm European Infants: a randomized phase IIIb study. Pediatr Infect Dis J. 2012;31(5):487–493pmid:22228231
      OpenUrlCrossRefPubMed
      1. Phua KB,
      2. Quak SH,
      3. Lee BW,
      4. et al
      . Evaluation of RIX4414, a live, attenuated rotavirus vaccine, in a randomized, double-blind, placebo-controlled phase 2 trial involving 2464 Singaporean infants. J Infect Dis. 2005;192(suppl 1):S6–S16pmid:16088807
      OpenUrlAbstract/FREE Full Text
      1. Phua KB,
      2. Lim FS,
      3. Lau YL,
      4. et al
      . Safety and efficacy of human rotavirus vaccine during the first 2 years of life in Asian infants: randomised, double-blind, controlled study. Vaccine. 2009;27(43):5936–5941pmid:19679216
      OpenUrlCrossRefPubMed
    40. Phua KB, Lim FS, Lau YL, et al. Rotavirus vaccine RIX4414 efficacy sustained during the third year of life: A randomized clinical trial in an Asian population. Vaccine. 2012;30(30):4552–4557
      1. Rodriguez ZM,
      2. Goveia MG,
      3. Stek JE,
      4. et al
      . Concomitant use of an oral live pentavalent human-bovine reassortant rotavirus vaccine with licensed parenteral pediatric vaccines in the United States. Pediatr Infect Dis J. 2007;26(3):221–227pmid:17484218
      OpenUrlCrossRefPubMed
      1. Ruiz-Palacios GM,
      2. Pérez-Schael I,
      3. Velázquez FR,
      4. et al.,
      5. Human Rotavirus Vaccine Study Group
      . Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med. 2006;354(1):11–22pmid:16394298
      OpenUrlCrossRefPubMed
      1. Sow SO,
      2. Tapia M,
      3. Haidara FC,
      4. et al
      . Efficacy of the oral pentavalent rotavirus vaccine in Mali. Vaccine. 2012;30(suppl 1):A71–A78pmid:22520140
      OpenUrlCrossRefPubMed
      1. Steele AD,
      2. Reynders J,
      3. Scholtz F,
      4. et al
      . Comparison of 2 different regimens for reactogenicity, safety, and immunogenicity of the live attenuated oral rotavirus vaccine RIX4414 coadministered with oral polio vaccine in South African infants. J Infect Dis. 2010;202(suppl):S93–S100pmid:20684724
      OpenUrlAbstract/FREE Full Text
      1. Steele AD,
      2. Madhi SA,
      3. Louw CE,
      4. et al
      . Safety, reactogenicity, and immunogenicity of human rotavirus vaccine RIX4414 in human immunodeficiency virus-positive infants in South Africa. Pediatr Infect Dis J. 2011;30(2):125–130pmid:20842070
      OpenUrlCrossRefPubMed
      1. Tregnaghi MW,
      2. Abate HJ,
      3. Valencia A,
      4. et al.,
      5. Rota-024 Study Group
      . Human rotavirus vaccine is highly efficacious when coadministered with routine expanded program of immunization vaccines including oral poliovirus vaccine in Latin America. Pediatr Infect Dis J. 2011;30(6):e103–e108pmid:21378594
      OpenUrlPubMed
      1. Vesikari T,
      2. Karvonen A,
      3. Puustinen L,
      4. et al
      . Efficacy of RIX4414 live attenuated human rotavirus vaccine in Finnish infants. Pediatr Infect Dis J. 2004;23(10):937–943pmid:15602194
      OpenUrlCrossRefPubMed
      1. Vesikari T,
      2. Clark HF,
      3. Offit PA,
      4. et al
      . Effects of the potency and composition of the multivalent human-bovine (WC3) reassortant rotavirus vaccine on efficacy, safety and immunogenicity in healthy infants. Vaccine. 2006;24(22):4821–4829pmid:16621194
      OpenUrlCrossRefPubMed
      1. Vesikari T,
      2. Matson DO,
      3. Dennehy P,
      4. et al.,
      5. Rotavirus Efficacy and Safety Trial (REST) Study Team
      . Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med. 2006;354(1):23–33pmid:16394299
      OpenUrlCrossRefPubMed
    41. Vesikari T, Karvonen A, Bouckenooghe A, Suryakiran PV, Smolenov I, Han HH. Immunogenicity, reactogenicity and safety of the human rotavirus vaccine RIX4414 oral suspension (liquid formulation) in Finnish infants. Vaccine. 2011;29(11):2079–2084
      1. Vesikari T,
      2. Karvonen A,
      3. Korhonen T,
      4. et al
      . Safety and immunogenicity of RIX4414 live attenuated human rotavirus vaccine in adults, toddlers and previously uninfected infants. Vaccine. 2004;22(21-22):2836–2842pmid:15246619
      OpenUrlCrossRefPubMed
    42. Zaman K, Sack DA, Yunus M, et al. Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age. Vaccine. 2009;27(9):1333–1339
      1. Zaman K,
      2. Dang DA,
      3. Victor JC,
      4. et al
      . Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;376(9741):615–623pmid:20692031
      OpenUrlCrossRefPubMed
    43. ↵
      1. Zaman K,
      2. Yunus M,
      3. El Arifeen S,
      4. et al
      . Methodology and lessons-learned from the efficacy clinical trial of the pentavalent rotavirus vaccine in Bangladesh. Vaccine. 2012;30(suppl 1):A94–A100pmid:22520143
      OpenUrlCrossRefPubMed
    44. ↵
      1. Buttery JP,
      2. Danchin MH,
      3. Lee KJ,
      4. et al.,
      5. PAEDS/APSU Study Group
      . Intussusception following rotavirus vaccine administration: post-marketing surveillance in the National Immunization Program in Australia. Vaccine. 2011;29(16):3061–3066pmid:21316503
      OpenUrlCrossRefPubMed
    45. ↵
      1. Velázquez FR,
      2. Colindres RE,
      3. Grajales C,
      4. et al
      . Postmarketing surveillance of intussusception following mass introduction of the attenuated human rotavirus vaccine in Mexico. Pediatr Infect Dis J. 2012;31(7):736–744pmid:22695189
      OpenUrlCrossRefPubMed
    46. ↵
      1. Patel MM,
      2. López-Collada VR,
      3. Bulhões MM,
      4. et al
      . Intussusception risk and health benefits of rotavirus vaccination in Mexico and Brazil. N Engl J Med. 2011;364(24):2283–2292pmid:21675888
      OpenUrlCrossRefPubMed
    47. ↵
      1. Shui IM,
      2. Baggs J,
      3. Patel M,
      4. et al
      . Risk of intussusception following administration of a pentavalent rotavirus vaccine in US infants. JAMA. 2012;307(6):598–604pmid:22318281
      OpenUrlCrossRefPubMed
    48. ↵
      Yih K, Lieu T, Kulldorff M, et al. Intussusception risk after rotavirus vaccination in U.S. infants. Mini-Sentinel Coordinating Center; June 2013. Available at: www.mini-sentinel.org/work_products/PRISM/Mini-Sentinel_PRISM_Rotavirus-and-intussusception-Report.pdf. Accessed June 30, 2013
    49. ↵
      1. Black S,
      2. Shinefield H,
      3. Ray P,
      4. et al
      . Postmarketing evaluation of the safety and effectiveness of varicella vaccine. Pediatr Infect Dis J. 1999;18(12):1041–1046pmid:10608621
      OpenUrlCrossRefPubMed
    50. ↵
      1. Donahue JG,
      2. Kieke BA,
      3. Yih WK,
      4. et al.,
      5. Vaccine Safety DataLink Team
      . Varicella vaccination and ischemic stroke in children: is there an association? Pediatrics. 2009;123(2). Available at: www.pediatrics.org/cgi/content/full/123/2/e228pmid:19171574
      OpenUrlAbstract/FREE Full Text
    51. ↵
      1. Groves FD,
      2. Gridley G,
      3. Wacholder S,
      4. et al
      . Infant vaccinations and risk of childhood acute lymphoblastic leukaemia in the USA. Br J Cancer. 1999;81(1):175–178pmid:10487630
      OpenUrlCrossRefPubMed
    52. ↵
      1. Ma X,
      2. Does MB,
      3. Metayer C,
      4. Russo C,
      5. Wong A,
      6. Buffler PA
      . Vaccination history and risk of childhood leukaemia. Int J Epidemiol. 2005;34(5):1100–1109pmid:15951359
      OpenUrlAbstract/FREE Full Text
    53. ↵
      1. MacArthur AC,
      2. McBride ML,
      3. Spinelli JJ,
      4. Tamaro S,
      5. Gallagher RP,
      6. Theriault GP
      . Risk of childhood leukemia associated with vaccination, infection, and medication use in childhood: the Cross-Canada Childhood Leukemia Study. Am J Epidemiol. 2008;167(5):598–606pmid:18079130
      OpenUrlAbstract/FREE Full Text
    54. ↵
      1. Pagaoa MA,
      2. Okcu MF,
      3. Bondy ML,
      4. Scheurer ME
      . Associations between vaccination and childhood cancers in Texas regions. J Pediatr. 2011;158(6):996–1002pmid:21227448
      OpenUrlCrossRefPubMed
    55. ↵
      1. Haber P,
      2. Iskander J,
      3. Walton K,
      4. Campbell SR,
      5. Kohl KS
      . Internet-based reporting to the vaccine adverse event reporting system: a more timely and complete way for providers to support vaccine safety. Pediatrics. 2011;127(suppl 1):S39–S44pmid:21502243
      OpenUrlAbstract/FREE Full Text
    • Copyright © 2014 by the American Academy of Pediatrics
    PreviousNext
    Back to top

    Advertising Disclaimer »

    In this issue

    Pediatrics
    Vol. 134, Issue 2
    1 Aug 2014
    • Table of Contents
    • Index by author
    View this article with LENS
    PreviousNext
    Email Article

    Thank you for your interest in spreading the word on American Academy of Pediatrics.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review
    (Your Name) has sent you a message from American Academy of Pediatrics
    (Your Name) thought you would like to see the American Academy of Pediatrics web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Request Permissions
    Article Alerts
    Log in
    You will be redirected to aap.org to login or to create your account.
    Or Sign In to Email Alerts with your Email Address
    Citation Tools
    Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review
    Margaret A. Maglione, Lopamudra Das, Laura Raaen, Alexandria Smith, Ramya Chari, Sydne Newberry, Roberta Shanman, Tanja Perry, Matthew Bidwell Goetz, Courtney Gidengil
    Pediatrics Aug 2014, 134 (2) 325-337; DOI: 10.1542/peds.2014-1079

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review
    Margaret A. Maglione, Lopamudra Das, Laura Raaen, Alexandria Smith, Ramya Chari, Sydne Newberry, Roberta Shanman, Tanja Perry, Matthew Bidwell Goetz, Courtney Gidengil
    Pediatrics Aug 2014, 134 (2) 325-337; DOI: 10.1542/peds.2014-1079
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    Print
    Download PDF
    Insight Alerts
    • Table of Contents

    Jump to section

    • Article
      • Abstract
      • Methods
      • Results
      • Discussion
      • Conclusions
      • Acknowledgments
      • Footnotes
      • References
    • Figures & Data
    • Info & Metrics
    • Comments

    Related Articles

    • No related articles found.
    • PubMed
    • Google Scholar

    Cited By...

    • When development is at stake: Fear the disease, not the vaccine
    • Rethinking Flu Vaccine Messaging
    • Identification, Evaluation, and Management of Children With Autism Spectrum Disorder
    • Determinants of vaccine hesitancy in Switzerland: study protocol of a mixed-methods national research programme
    • Characteristics of stakeholder involvement in systematic and rapid reviews: a methodological review in the area of health services research
    • Repondre a lhesitation face a la vaccination: Conseils cliniques a lintention des medecins de premiere ligne qui travaillent avec les parents
    • Addressing vaccine hesitancy: Clinical guidance for primary care physicians working with parents
    • Simply put: Vaccination saves lives
    • Countering Vaccine Hesitancy
    • Childhood Vaccine Exemptions: A Broader Perspective Is Required
    • Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology
    • Effect of bivalent human papillomavirus vaccination on pregnancy outcomes: long term observational follow-up in the Costa Rica HPV Vaccine Trial
    • Vaccine Safety: Medical Contraindications, Myths, and Risk Communication
    • Measles 2015: Why Public Health Matters to Critical Care
    • Vaccines: Can Transparency Increase Confidence and Reduce Hesitancy?
    • Google Scholar

    More in this TOC Section

    • Machine Learning for Child and Adolescent Health: A Systematic Review
    • Effects of Probiotics in Preterm Infants: A Network Meta-analysis
    • Adverse Childhood Experiences and Justice System Contact: A Systematic Review
    Show more Review Article

    Similar Articles

    Subjects

    • Infectious Disease
      • Infectious Disease
      • Vaccine/Immunization
    • Evidence-Based Medicine
      • Evidence-Based Medicine

    Keywords

    • evidence-based medicine
    • vaccine/immunization
    • infectious disease
    • Journal Info
    • Editorial Board
    • Editorial Policies
    • Overview
    • Licensing Information
    • Authors/Reviewers
    • Author Guidelines
    • Submit My Manuscript
    • Open Access
    • Reviewer Guidelines
    • Librarians
    • Institutional Subscriptions
    • Usage Stats
    • Support
    • Contact Us
    • Subscribe
    • Resources
    • Media Kit
    • About
    • International Access
    • Terms of Use
    • Privacy Statement
    • FAQ
    • AAP.org
    • shopAAP
    • Follow American Academy of Pediatrics on Instagram
    • Visit American Academy of Pediatrics on Facebook
    • Follow American Academy of Pediatrics on Twitter
    • Follow American Academy of Pediatrics on Youtube
    • RSS
    American Academy of Pediatrics

    © 2021 American Academy of Pediatrics