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American Academy of Pediatrics
Article

The Timing of Cord Clamping and Oxidative Stress in Term Newborns

Javier Díaz-Castro, Jesus Florido, Naroa Kajarabille, Maria Garrido-Sánchez, Carmen Padilla, Catalina de Paco, Luis Navarrete and Julio J. Ochoa
Pediatrics August 2014, 134 (2) 257-264; DOI: https://doi.org/10.1542/peds.2013-3798
Javier Díaz-Castro
aDepartment of Physiology, and
bInstitute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Granada, Spain;
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Jesus Florido
cDepartment of Obstetrics and Gynaecology, School of Medicine, University of Granada, Granada, Spain; and
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Naroa Kajarabille
aDepartment of Physiology, and
bInstitute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Granada, Spain;
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Maria Garrido-Sánchez
cDepartment of Obstetrics and Gynaecology, School of Medicine, University of Granada, Granada, Spain; and
dService of Obstetrics and Gynaecology, University Hospital San Cecilio, Granada, Spain
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Carmen Padilla
cDepartment of Obstetrics and Gynaecology, School of Medicine, University of Granada, Granada, Spain; and
dService of Obstetrics and Gynaecology, University Hospital San Cecilio, Granada, Spain
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Catalina de Paco
cDepartment of Obstetrics and Gynaecology, School of Medicine, University of Granada, Granada, Spain; and
dService of Obstetrics and Gynaecology, University Hospital San Cecilio, Granada, Spain
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Luis Navarrete
cDepartment of Obstetrics and Gynaecology, School of Medicine, University of Granada, Granada, Spain; and
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Julio J. Ochoa
aDepartment of Physiology, and
bInstitute of Nutrition and Food Technology “José Mataix Verdú”, University of Granada, Granada, Spain;
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Abstract

BACKGROUND: Clamping and cutting of the umbilical cord is the most prevalent of all operations, but the optimal timing of cord clamping is controversial, with different timings offering advantages and disadvantages. This study, for the first time, compares the influence of early and late cord clamping in correlation with oxidative stress and inflammation signaling, Because cord clamping timing may have a significant influence on placenta-to-infant blood transfer, thereby modifying oxygenation of maternal and fetal tissues, and on the transfer of inflammatory mediators throughout the placenta.

METHODS: Sixty-four pregnant subjects were selected at the Gynecology and Obstetrics Services Department of the Clinico San Cecilio Hospital, Granada, Spain, based on disease-free women who experienced a normal course of pregnancy and a spontaneous, vaginal, single delivery. Half of the subjects had deliveries with early-clamped newborn infants (at 10 s), and the other half had late-clamped deliveries (at 2 min).

RESULTS: Erythrocyte catalase activity was significantly greater in the late-clamped group than in the early-clamped group (P < .01 for the umbilical vein and P < .001 for the artery). The values for superoxide dismutase, total antioxidant status, and soluble tumor necrosis factor receptor II were all significantly higher in the late-clamped group compared with the early-clamped group (P < .01, P < .001, and P < .001, respectively).

CONCLUSIONS: The results suggest a beneficial effect of late cord clamping, produced by an increase in antioxidant capacity and moderation of the inflammatory-mediated effects induced during delivery of term neonates.

  • cord clamping timing (early or late)
  • term neonate
  • antioxidant defense
  • oxidative damage
  • inflammation
  • Accepted May 21, 2014.
  • Copyright © 2014 by the American Academy of Pediatrics

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Pediatrics
Vol. 134, Issue 2
1 Aug 2014
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The Timing of Cord Clamping and Oxidative Stress in Term Newborns
Javier Díaz-Castro, Jesus Florido, Naroa Kajarabille, Maria Garrido-Sánchez, Carmen Padilla, Catalina de Paco, Luis Navarrete, Julio J. Ochoa
Pediatrics Aug 2014, 134 (2) 257-264; DOI: 10.1542/peds.2013-3798

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The Timing of Cord Clamping and Oxidative Stress in Term Newborns
Javier Díaz-Castro, Jesus Florido, Naroa Kajarabille, Maria Garrido-Sánchez, Carmen Padilla, Catalina de Paco, Luis Navarrete, Julio J. Ochoa
Pediatrics Aug 2014, 134 (2) 257-264; DOI: 10.1542/peds.2013-3798
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