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Article

Prenatal Nutrient Supplementation and Postnatal Growth in a Developing Nation: An RCT

Hermann Lanou, Lieven Huybregts, Dominique Roberfroid, Laetitia Nikièma, Séni Kouanda, John Van Camp and Patrick Kolsteren
Pediatrics April 2014, 133 (4) e1001-e1008; DOI: https://doi.org/10.1542/peds.2013-2850
Hermann Lanou
aInstitut de Recherche en Sciences de la Santé, Ministry of Scientific Research and Innovation, Ouagadougou, Burkina Faso;
cChild Health and Nutrition Unit, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium
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Lieven Huybregts
bDepartment of Food Safety and Food Quality, Ghent University, Ghent, Belgium; and
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Dominique Roberfroid
cChild Health and Nutrition Unit, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium
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Laetitia Nikièma
aInstitut de Recherche en Sciences de la Santé, Ministry of Scientific Research and Innovation, Ouagadougou, Burkina Faso;
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Séni Kouanda
aInstitut de Recherche en Sciences de la Santé, Ministry of Scientific Research and Innovation, Ouagadougou, Burkina Faso;
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John Van Camp
bDepartment of Food Safety and Food Quality, Ghent University, Ghent, Belgium; and
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Patrick Kolsteren
bDepartment of Food Safety and Food Quality, Ghent University, Ghent, Belgium; and
cChild Health and Nutrition Unit, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium
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This article has a correction. Please see:

  • Lanou et al. Prenatal Nutrient Supplementation and Postnatal Growth in a Developing Nation: An RCT. Pediatrics. 2014;133(4): e1001–e1008 - May 01, 2016

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Abstract

BACKGROUND AND OBJECTIVES: Prenatal lipid-based nutrient supplements (LNS) have been shown to improve birth anthropometry. However, little is known about the effects of such supplements on infant health. We hypothesized that prenatal LNS compared with multiple micronutrient supplement for pregnant and lactating women would improve survival, growth, and morbidity during infancy.

METHODS: Infants’ weight, length, head, chest, and mid-upper arm circumferences were measured during monthly home visits from birth to 12 months of age in the Micronutriments et Santé de la Mère et de l’Enfant—2 trial. Differences in stunting and wasting episodes between study arms were assessed by Cox regression for recurrent event models. Morbidity signs during the 2 weeks before the visits and death cases were also assessed by multilevel analysis accounting for repeated individual measurements.

RESULTS: Infant length-for-age growth (–0.033 z score/month; 95% confidence interval: –0.601 to –0.006; P = .018) for the LNS group was inferior to that of the control group. We did not find evidence of significant difference in mortality or morbidity between groups.

CONCLUSIONS: The previously reported positive effect of prenatal LNS on birth length was not sustained during the postnatal phase. Prenatal LNS does not appear to make a long-lasting difference in child linear growth.

  • lipid-based nutrient supplement
  • pregnancy
  • growth
  • infancy
  • Accepted January 3, 2014.
  • Copyright © 2014 by the American Academy of Pediatrics

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Pediatrics
Vol. 133, Issue 4
1 Apr 2014
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Prenatal Nutrient Supplementation and Postnatal Growth in a Developing Nation: An RCT
Hermann Lanou, Lieven Huybregts, Dominique Roberfroid, Laetitia Nikièma, Séni Kouanda, John Van Camp, Patrick Kolsteren
Pediatrics Apr 2014, 133 (4) e1001-e1008; DOI: 10.1542/peds.2013-2850

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Prenatal Nutrient Supplementation and Postnatal Growth in a Developing Nation: An RCT
Hermann Lanou, Lieven Huybregts, Dominique Roberfroid, Laetitia Nikièma, Séni Kouanda, John Van Camp, Patrick Kolsteren
Pediatrics Apr 2014, 133 (4) e1001-e1008; DOI: 10.1542/peds.2013-2850
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  • Lanou et al. Prenatal Nutrient Supplementation and Postnatal Growth in a Developing Nation: An RCT. Pediatrics. 2014;133(4): e1001–e1008
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