- BPA —
- bisphenol A
- DEHP —
This month Pediatrics has published 2 articles on environmental chemical exposures that warrant commentary, “Urinary Phthalates and Increased Insulin Resistance in Adolescents” (Trasande et al1) and “Bisphenol A and Chronic Disease Risk Factors in US Children” (Eng et al2). Both of these articles use the urinary content of the chemical as a surrogate for the chemical exposure.
Dr Trasande and his group in the article on phthalates conclude that urine phthalate concentrations (represented by urine di-2-ethylhexylphthalate [DEHP] concentrations) were associated with increased insulin resistance in this cross-sectional study of adolescents. Dr Trasande refers to this as an association and indicated that this study cannot rule out the possibility that insulin-resistant children ingest food with higher phthalate content or that insulin-resistant children excrete more DEHP. Without knowing the tissue or serum concentration of DEHP or referring to primate studies, the authors’ hypotheses are appropriate.
The second article by Eng et al deals with bisphenol A (BPA). It is most important for authors to be familiar with the literature concerning the chemical that they are evaluating. Unfortunately, the BPA article fails to cite important publications dealing …
Address correspondence to Robert L. Brent, MD, PhD, DSc, Thomas Jefferson University, Alfred I. DuPont Hospital for Children, Room 308 A/R, 1600 Rockland Rd, Wilmington, DE 19803. E-mail: