Skip to main content

Advertising Disclaimer »

Main menu

  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers
  • Other Publications
    • American Academy of Pediatrics

User menu

  • Log in
  • My Cart

Search

  • Advanced search
American Academy of Pediatrics

AAP Gateway

Advanced Search

AAP Logo

  • Log in
  • My Cart
  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers

Discover Pediatric Collections on COVID-19 and Racism and Its Effects on Pediatric Health

American Academy of Pediatrics
Article

Effective Analgesia Using Physical Interventions for Infant Immunizations

John W. Harrington, Stacey Logan, Courtney Harwell, Jessica Gardner, Jessica Swingle, Erin McGuire and Rosemarie Santos
Pediatrics May 2012, 129 (5) 815-822; DOI: https://doi.org/10.1542/peds.2011-1607
John W. Harrington
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stacey Logan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Courtney Harwell
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jessica Gardner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jessica Swingle
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Erin McGuire
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rosemarie Santos
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Comments
Loading
Download PDF

Abstract

BACKGROUND: To measure the analgesic effectiveness of the 5 S’s (swaddling, side/stomach position, shushing, swinging, and sucking) alone and combined with sucrose, during routine immunizations at 2 and 4 months.

METHODS: We conducted a prospective, randomized, placebo-controlled trial with 2- and 4-month-old infants during well-child visits. Patients were assigned into 4 groups (2 × 2) receiving either 2 mL of water or 2 mL of 24% oral sucrose and then either standard-of-care comfort measures by parents or intervention with the 5 S’s immediately postvaccination. The Modified Riley Pain Score was used to score the infants’ pain at 15-second intervals for 2 minutes, then every 30 seconds up to 5 minutes postvaccination. Repeated-measures analysis of variance examined between group differences and within-subject variability of treatment effect on overall pain scores and length of crying.

RESULTS: Two hundred thirty infants were enrolled. Results revealed significantly different mean pain scores between study groups with the exception of the 5S’s and 5S’s with sucrose groups. These 2 groups had lower similar mean scores over time, followed by sucrose alone, then control. The same trend was found with the proportion of children crying as with the mean pain score outcome measure.

CONCLUSIONS: Physical intervention of the 5 S’s (swaddling, side/stomach position, shushing, swinging, and sucking) provided decreased pain scores on a validated pain scale and decreased crying time among 2- and 4-month-old infants during routine vaccinations. The use of 5S’s did not differ from 5S’s and sucrose.

KEY WORDS
  • immunizations
  • vaccines
  • pain management
  • infant
  • analgesia
  • Abbreviations:
    5 S’s —
    swaddling, side/stomach position, shushing, swinging, and sucking
    ANOVA —
    analysis of variance
    IRB —
    internal review board
  • What’s Known on This Subject:

    Pain during routine infant immunization causes parental anxiety. Oral sucrose solutions are effective pain-reduction strategies. Few studies have measured a combined strategy of a physical intervention along with sucrose to decrease the infant’s pain response.

    What This Study Adds:

    We demonstrate that a physical, nonpharmacological intervention called the 5 S’s (swaddling, side/stomach position, shushing, swinging, and sucking) provides significant pain reduction with or without sucrose during routine 2- and 4-month vaccinations.

    Immunization administration is one of the most common office procedures performed on a healthy infant in a pediatric practice.1 Although parents understand the importance of immunizations, the pain and discomfort associated with this procedure is the primary reason parents elect not to perform timely vaccinations.2 Parents are not the only ones concerned about causing unwanted pain. Physicians and nurses are 6 times less likely to give all the recommended vaccines at a visit if the number of injections is ≥33 and physicians have “strong concerns over administering 4 or more vaccines at a single visit.”4

    It is clear that clinicians would like to reduce the pain and parental anxiety, during and soon after vaccination; however, there is little evidence that the use of analgesics such as acetaminophen or ibuprofen are effective.5,6 One study surveyed 140 pediatricians and found that >80% used acetaminophen, which has added sucrose for palatability as an oral analgesic, pre- or postvaccination, as a pain-reducing mechanism.7 However, a more recent study conducted by Pyrmula found that acetaminophen use at the time of vaccination significantly reduces antibody levels to several of the vaccine antigens.8 In light of this finding, it is prudent to reevaluate the use of oral antipyretic analgesics with sucrose during routine vaccination and provide alternative pain-reduction mechanisms. Nonpharmacologic pain relief may be the best option for infants undergoing painful procedures.

    Recent reviews of the literature support the use of concentrated sucrose alone as effective analgesia for the immunization of infants.9–12 Although topical anesthetics work,13 they are generally not used in a busy practice because of expense and a prolonged waiting period after application. Additional interventions to reduce pain during procedures in neonates include nonnutritive suck, breastfeeding, skin-to-skin, and swaddling.14–19 Two studies report moderate success at alleviating infant pain when combining 2 nonpharmacologic techniques together: (1) swaddle and pacifier20 or (2) swaddle and sucrose.21 Psychological interventions, in which a parent or nurse distracts the infant with a toy or a parent is coached by a health care provider, have also shown some promise.22 Taddio et al have advocated for health care providers to consider combining multiple strategies to help mitigate pain and to enlist parental support when possible.9 Breastfeeding combines several analgesic effects (a comforting person [mother], skin-to-skin contact, diversion of attention, and the sweetness of lactose) as effective for procedural pain.23–25 Unfortunately, if the mother is no longer breastfeeding or if she would rather not breastfeed while the baby receives immunizations, than alternative analgesic techniques are necessary.

    In his book The Happiest Baby on the Block,26 Dr Harvey Karp describes the 5 S’s: swaddling, side/stomach position, shushing, swinging, and sucking and explains how these interventions together trigger an infant’s calming reflex. The primary objective of our study was to identify if the 5 S’s could be used as a physical intervention to provide analgesia to infants receiving immunizations.

    Methods

    Randomized Controlled Trial

    This was a prospective, randomized, partially blinded, controlled study designed to test the effectiveness of a physical intervention by using the 5 S’s for analgesic pain control, alone and in conjunction with sucrose analgesia, after routine immunizations at 2 and 4 months of age. This study was approved by the Internal Review Board (IRB) at Eastern Virginia Medical School and was registered with clinicaltrials.gov (NCT01368861).

    Statistical Analysis

    Power Analysis

    The primary outcome variable of pain score was evaluated by using a total sample of 230 distributed evenly across 4 groups. A 1-way analysis of variance (ANOVA) has 99% power to detect at the .05 level a difference in means of pain scores characterized by a variance of means of .19, assuming that the common SD is 0.43.

    Secondary analyses were conducted by using a .05 level χ2 test, yielding 99% power to detect differences in crying among participants characterized by a variance of proportions of 0.024 and an average proportion of 0.20.

    Statistical Methodology

    Demographics variables such as age, gender, and race were evaluated for significant differences between intervention groups by using χ2 analysis. For remaining demographic variables such as gestational age and weight at birth, 1-way ANOVA tests were used to determine if there were significant differences between intervention groups.

    To evaluate mean pain across intervention groups over time, a 1-way ANOVA was used followed by least significant difference post hoc comparisons. To evaluate pain scores at each time interval across intervention groups, repeated measure general linear modeling was performed.

    To determine significant differences in proportions of children crying at each time interval, χ2 analyses were performed.

    For all statistical tests, a P value <.05 was considered significant.

    Study Sample and Group Randomization

    All patients were enrolled from the General Academic Pediatric outpatient practice located at the Children’s Hospital of the King’s Daughters in Norfolk, VA. This practice serves a predominantly urban, Medicaid-enrolled, African American population and has ∼30 000 annual visits per year. Inclusion criteria included infants with a gestational age between 32 and 42 weeks at delivery and postnatal age of <20 weeks. Exclusion criteria included acetaminophen or ibuprofen administration within 4 hours before immunization, current neurologic disorder, known genetic anomaly, moderate to severe illness with or without fever at the time of vaccination, anaphylactic reaction to previous dose of vaccine, or if infant was previously enrolled in the study at 2 months.

    Study Procedure

    Infants meeting inclusion criteria were identified daily by reviewing the list of patients scheduled for a 2- or 4-month well-child visit at the outpatient site. The parent or legal guardian was approached before vaccination by the research assistant for participation in the study. If the parent or guardian accepted participation in the vaccine study, the consenting process was performed, and patients were brought to a designated examination room. Infants of parents or guardians who consented were randomly assigned to 1 of 4 study groups by using presealed cards. The cards were then selected by the nurses and only reviewed by the nurses to instruct them as to the group assignment. Ten cards were assigned to each group for a total of 40 cards, which were recycled with each group of 40 infants enrolled into the study. The 4 groups of the study included the following:

    1. 2 mL of water 2 minutes before immunization and comfort by parent or guardian after immunization (Control Group),

    2. 2 mL of 24% oral sucrose 2 minutes before immunization and comfort by parent or guardian after immunization (Sucrose Group),

    3. 2 mL of water 2 minutes before immunization and physical intervention using the 5 S’s by researcher after immunization (Physical Group), and

    4. 2 mL of 24% oral sucrose 2 minutes before immunization and physical intervention using the 5 S’s by researcher after immunization (Physical and Sucrose Group).

    The nursing staff administering the immunizations selected an opaque presealed card and a prefilled syringe according to the card instructions. The prefilled syringes, labeled as “water” or “sugar” in zip-lock bags, were kept in the examination room. The emptied syringe would then be placed into an obscured sharps container after the contents were given to the infant. The trained observer, who would be grading the infant response, would then enter the immunization room after the infant had received the syringe contents and the syringe had been placed in the sharps container.

    Every infant enrolled in the study was given a 2-mL solution of either water or 24% oral sucrose 2 full minutes before the administration of immunizations. The oral sucrose solution consisted of a 24% disaccharide solution (TootSweet 24%; Hawaii Medical, Seattle, WA), which has 240 mg of sugar per milliliter. The investigators and observer were blinded to which 2-mL solution each infant received at the beginning of the study. Investigator and parent were simply told by the nurses whether the infant was in the physical intervention group or parent comfort group.

    The vaccinations used during the study were those that are routinely used at the practice site to meet the American Academy of Pediatrics requirements. Vaccines were administered in a standardized prescribed fashion of rapid injection and no aspiration technique by the same 2 senior nurses. After the 2-mL solution administration, each infant was given routine well vaccinations with oral (1.5 mL) Rotarix first, followed by 3 intramuscular injections (0.5 mL) in alternating thighs of hepatitis B vaccine, Pentacel (combined diphtheria-tetanus-acellular pertussis/Inactivated polio vaccine-Haemophilus influenza type b) and Prevnar given last because of its documented increased discomfort noted in previous studies.27 All injectable vaccinations were predrawn into a 1-mL syringe under sterile technique and administered intramuscularly to the anterior thigh at a 90° angle to the skin with a 23-gauge 1.59-cm needle by senior nursing staff. The third and last injection was placed lateral to the first with >3 cm between shots given in the same leg. All injections were given with the infant lying on the examination table. When the last injection was finished, the parent or caregiver in the non–physical intervention group was allowed to soothe and hold the baby by using any techniques they wished (swaddle, shushing, sucking on a pacifier, breastfeeding, etc.). Comfort strategies by the parents or caregivers were not collected, and therefore no statistical analysis could be done.

    Physical Intervention

    For the physical groups, additional criteria were outlined for study inclusion. Three pediatric resident physicians viewed the 5S’s video and practiced rapidly swaddling the infant. The infants would have the blanket placed underneath them during the immunizations to facilitate swaddling. Each resident was required to have each infant swaddled within 15 seconds postvaccination, begin side/stomach position with shushing and swinging/swaying with the pacifier provided after 30 seconds. As suggested by Dr Karp, the pacifier was the last of the 5 S’s implemented during the physical intervention group because the infant should slowly be calming, and the nonnutritive suck theoretically helps soothe the infant even more.25 Large, square 47 × 47 inch cotton muslin Aden and Anais blankets were used during the investigation to ensure secure swaddling of all infants. All 5 S’s were incorporated to the best ability of the pediatric resident. A minimum completion of 4 of 5 physical interventions needed to be successfully completed by the resident for inclusion in the study (to see a video of the 5S’s preformed, go to http://www.youtube.com/watch?v=WkR_e1L6zxI).

    Data Collection

    The subject age, gender, ethnicity, current weight, and gestational age were recorded. One resident preformed the function of being the timer, and a stop watch was started immediately after the injection of the third and final vaccination in the series to commence the assessment of pain. Table 1 shows the modified Riley Infant Pain Scoring Method used to measure the infant’s pain score postvaccination.28 Infant’s scores were based on 3 behaviors: quality of cry (eg, from whimpering to high-pitched scream), facial grimace, and body movement by using 15-second intervals for a minimum of 2 minutes and then every 30 seconds to a maximum 5 minutes’ postvaccination. After the infant was calm, scoring was continued for an additional 1 minute postcry. There was a minimum score of 0 to a maximum score of 3 for each behavior. The lowest possible total pain score was 0, and the highest total pain score was 9. A single research assistant was present to score all infant assessments of pain and crying. A slight modification of facial scoring method was used for the term “clenched teeth”; the observer substituted “clenched jaw/mouth.”

    View this table:
    • View inline
    • View popup
    TABLE 1

    Modified Riley Pain Score

    Results

    Patients were recruited over a 6-month period from May 1 through October 31, of 2010. As indicated in Fig 1, 286 two- and four-month-old patients who were scheduled to receive vaccines were screened for participation in the study. Ninety-four percent (270) met inclusion criteria, and of those, 87% (234) agreed to participate. Four subjects were excluded after enrollment by our IRB after data collection because a directly translated Spanish consent form did not have an official stamp from the IRB and was deemed unacceptable. Of these patients, 56 were randomly assigned to the control group, 58 to the sucrose group, 58 to the physical group, and 58 to the physical and sucrose group. Demographic data for each of the groups is listed in Table 2. Overall, 73% were 2-month-olds, 54% were boys, 81% were African American, and 13% were Caucasian. Demographic variables did not vary significantly between study groups.

    FIGURE 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1

    Randomization table.

    View this table:
    • View inline
    • View popup
    TABLE 2

    Characteristics of Participating Population

    Four of the first 5S’s were completed in 100% of the patients, and our residents found that “sucking” was the most difficult of the 5 S’s to complete for 3 reasons: extreme discomfort, the infant had already become calm, or the infant was unaccustomed to using a pacifier.

    Repeated-measure ANOVAs in Fig 2 show that for all groups, pain significantly decreased over time; post hoc testing also showed a significant difference in mean pain scores for each group over time. In terms of mean pain scores, all groups were significantly less than control, and the 5S’s only group was significantly less than the sucrose group as well. In addition to the repeated-measure ANOVA, a 1-way ANOVA was performed to explore differences in mean modified Riley Pain Scores that were averaged over the first 120 seconds. Table 3 reveals that the mean Riley Pain Score averaged over the first 120 seconds was 4.46 for the control group, 3.95 for the sucrose group, 3.24 for the physical group, and 3.61 for the physical and sucrose group. Overall, the mean pain score for the 5S’s group was 1.2 points less than the control group. Post hoc analysis revealed significantly different mean pain scores between study groups (P < .001) with the exception of the physical and physical with sucrose groups (P = .11). These 2 groups had similar mean scores throughout, which were the lowest over time, followed by sucrose alone and then control. There was a trend toward greater efficacy of all interventions in the 2-month age range over the 4-month age range, although this was not statistically significant (P = .077). In the sucrose, physical, and physical and sucrose groups, the 2-month-old patients had lower mean pain scores than the 4-month-olds, as shown in Table 3.

    FIGURE 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2

    Mean modified Riley Pain Score over time by intervention.

    View this table:
    • View inline
    • View popup
    TABLE 3

    Average Modified Riley Pain Score Over 120 Seconds by Age

    Similarly, the χ2 analysis in Fig 3 reveals a significantly different percent of children crying at 45, 60, 75, 90, and 105 seconds between the control, sucrose, and the 2 physical groups at P < .01. The same trend was found with the proportion of children crying as with the median pain score outcome measure. The lowest proportion of children crying at each of the times was found in the physical and physical with sucrose groups.

    FIGURE 3
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3

    Percent of participants crying over time by intervention.

    Discussion

    This study demonstrates that the physical intervention of the 5 S’s resulted in decreased pain scores and decreased crying time among 2- and 4-month-old infants during their routine vaccinations. The 5 S’s appear to be a viable nonpharmacologic option for clinics to implement when providing analgesia during vaccinations. In this study, the researchers alone implemented the physical intervention; however, interested caregivers were instructed in performing the 5 S’s for future immunizations.

    The use of sucrose has been well established to reduce pain in infants during vaccination or procedures, and it has been suggested that it should be the standard of care.11 However, it is unknown whether concomitant use of other analgesics with sucrose may produce a combined effect. We hypothesized that sucrose and our physical intervention together would have a synergistic effect in decreasing pain. However, the pain scores and crying time in the group of physical intervention alone were essentially identical and sometimes even lower than the physical intervention with sucrose group. More important, both groups using the physical intervention showed decreased pain scores when compared with the sucrose only group. In addition, when looking at the percent of infants crying at the set time points, there were significantly fewer infants crying who received the physical intervention when compared with the sucrose-only or control groups. Thus, the physical intervention of the 5 S’s had more of an analgesic effect than sucrose, yet there did not appear to be an overall synergistic effect with sucrose. Future studies should be done to see if these findings of the 5 S’s can be replicated, as well as effectively taught to parents in a clinical setting.

    We had several inherent and methodologic limitations in our study. We had a disproportionate number of 2-month-olds compared with 4-month-olds because of our exclusion criteria for 4-month-olds being ineligible if enrolled at their 2-month appointment. In addition, when the researchers performed the 5 S’s, it was noted that the technique was much easier to perform on the smaller 2-month-olds compared with the bigger and heavier 4-month-olds. These 2 factors make our results difficult to interpret for the older infant. For example, when looking at our results for percent crying and age, it appears that the 2-month-old group is driving the significance for percent crying by intervention at times 45 seconds, 75 seconds, 90 seconds, and 105 seconds. However, it is impossible to tell if the significance is being driven by the difference in age between 2 and 4 month olds or because there was a limited number of 4-month-olds for comparison.

    Although the pain scoring was all done by a single researcher, there were 3 researchers who performed the physical intervention of the 5 S’s, and each may have had a slightly different technique in swaddling. However, all the residents who performed the 5S’s practiced and viewed the online video mentioned earlier in the text until they could complete the process in <15 seconds. Other limitations were noted in the modified Riley Pain Score itself, because the behavior of body movement may have been restricted by a tight swaddling and therefore would have made it difficult to accurately assess body movement in the intervention group.

    Our study population was predominantly African American (79.5%) based on the population that the clinic serves and may not be generalizable to other populations of patients.

    Our control group was made up of the caregivers, and in an attempt to comfort their children, they instinctively did some of the 5 S’s. According to Harvey Karp’s book Happiest Baby on the Block, you need at least 3 of the 5 S’s to elicit the calming reflex, and usually the mother would do 2 of the S’s, including shushing in their ear and having them suck on a pacifier. However there were some instances when a mother in the control group would do 3 or more of the S’s, thus possibly eliciting the calming reflex. This may account for the few outliers we had in the control group.

    Another concern reflects methodologic issues with waiting 2 minutes after the sucrose administration. Some authors have theorized that the length of analgesic time for sucrose is different between the pre- and postneonatal period,29 extrapolating that sequential doses of sucrose would modulate this effect in older infants.30,31 Conversely, the introduction of the oral Rotarix and Rotateq into the series of immunizations given at 2 and 4 months also introduces the chance for the infant to be exposed to an incipient dose of dextran or sucrose in the vaccine. The concentration of the incipient, however, is significantly less than what is found in 24% sucrose (the ratio being 240 mg/mL to 6 mg/mL), and the vaccines were given immediately after the oral vaccine dose. Therefore, it is unlikely that the oral vaccine had any measurable analgesic effect given that there have been studies showing no added analgesic effect from formula after 24% sucrose32,33 and that 12% sucrose was considered insufficiently sweet to exert an analgesic effect.34,35

    Conclusions

    Overall, our study concluded that the physical intervention of the 5 S’s (swaddling, side/stomach position, shushing, swinging, and sucking) provided decreased pain scores on a validated pain scale and decreased crying time among 2- and 4-month-old infants immediately after routine vaccinations. The use of 5 S’s did not differ from the use of 5 S’s and sucrose. This simple physical intervention will require additional studies to see whether it is reproducible for other painful procedures and whether parents can be taught to perform the 5 S’s reliably.

    Acknowledgments

    We thank the nursing staff at General Academic Pediatrics at Children’s Hospital of the King’s Daughters and our patients for allowing us to perform this study during normal working hours.

    Footnotes

      • Accepted January 11, 2012.
    • Address correspondence to John W. Harrington, MD, Department of Pediatrics, Children’s Hospital of The King’s Daughters, 601 Children’s Lane, Norfolk, VA 23507; E-mail: John.Harrington{at}chkd.org
    • This trial has been registered at www.clinicaltrials.gov (identifier NCT01368861).

    • FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.

    • FUNDING: No external funding.

    References

    1. ↵
      1. Tuck RH
      . Coding and payment for immunizations. Pediatr Ann. 2006;35(7):507–512pmid:16895151
      OpenUrlPubMed
    2. ↵
      1. Jacobson RM,
      2. Swan A,
      3. Adegbenro A,
      4. Ludington SL,
      5. Wollan PC,
      6. Poland GA,
      7. Vaccine Research Group
      . Making vaccines more acceptable—methods to prevent and minimize pain and other common adverse events associated with vaccines. Vaccine. 2001;19(17–19):2418–2427pmid:11257372
      OpenUrlCrossRefPubMed
    3. ↵
      1. Reis EC
      . Multiple scheduled injections contribute to missed opportunities to immunize during well care visits. Ambul Child Health. 1997;3(1):172
      OpenUrl
    4. ↵
      1. Woodin KA,
      2. Rodewald LE,
      3. Humiston SG,
      4. Carges MS,
      5. Schaffer SJ,
      6. Szilagyi PG
      . Physician and parent opinions. Are children becoming pincushions from immunizations? Arch Pediatr Adolesc Med. 1995;149(8):845–849pmid:7633536
      OpenUrlCrossRefPubMed
    5. ↵
      1. Shah V,
      2. Taddio A,
      3. Ohlsson A
      . Randomised controlled trial of paracetamol for heel prick pain in neonates. Arch Dis Child Fetal Neonatal Ed. 1998;79(3):F209–F211pmid:10194994
      OpenUrlAbstract/FREE Full Text
    6. ↵
      1. Howard CR,
      2. Howard FM,
      3. Weitzman ML
      . Acetaminophen analgesia in neonatal circumcision: the effect on pain. Pediatrics. 1994;93(4):641–646pmid:8134222
      OpenUrlAbstract/FREE Full Text
    7. ↵
      1. Taddio A,
      2. Manley J,
      3. Potash L,
      4. Ipp M,
      5. Sgro M,
      6. Shah V
      . Routine immunization practices: use of topical anesthetics and oral analgesics. Pediatrics. 2007;120(3). Available at: www.pediatrics.org/cgi/content/full/120/3/e637pmid:17766503
      OpenUrlAbstract/FREE Full Text
    8. ↵
      1. Prymula R,
      2. Siegrist CA,
      3. Chlibek R,
      4. et al
      . Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet. 2009;374(9698):1339–1350pmid:19837254
      OpenUrlCrossRefPubMed
    9. ↵
      1. Taddio A,
      2. Appleton M,
      3. Bortolussi R,
      4. et al
      . Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline. CMAJ. 2010;182(18):E843–E855pmid:21098062
      OpenUrlCrossRefPubMed
      1. Stevens B,
      2. Yamada J,
      3. Ohlsson A
      . Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2010;1(1):CD001069pmid:20091512
      OpenUrlPubMed
    10. ↵
      1. Harrison D,
      2. Bueno M,
      3. Yamada J,
      4. Adams-Webber T,
      5. Stevens B
      . Analgesic effects of sweet-tasting solutions for infants: current state of equipoise. Pediatrics. 2010;126(5):894–902pmid:20937658
      OpenUrlAbstract/FREE Full Text
    11. ↵
      1. Harrison D,
      2. Stevens B,
      3. Bueno M,
      4. et al
      . Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review. Arch Dis Child. 2010;95(6):406–413pmid:20463370
      OpenUrlAbstract/FREE Full Text
    12. ↵
      1. Lindh V,
      2. Wiklund U,
      3. Blomquist HK,
      4. Håkansson S
      . EMLA cream and oral glucose for immunization pain in 3-month-old infants. Pain. 2003;104(1-2):381–388pmid:12855349
      OpenUrlCrossRefPubMed
    13. ↵
      1. Bo LK,
      2. Callaghan P
      . Soothing pain-elicited distress in Chinese neonates. Pediatrics. 2000;105(4). Available at: www.pediatrics.org/cgi/content/full/105/4/e49pmid:10742370
      OpenUrlAbstract/FREE Full Text
      1. Field T,
      2. Goldson E
      . Pacifying effects of nonnutritive sucking on term and preterm neonates during heelstick procedures. Pediatrics. 1984;74(6):1012–1015pmid:6504620
      OpenUrlAbstract/FREE Full Text
      1. Leite AM,
      2. Linhares MB,
      3. Lander J,
      4. Castral TC,
      5. dos Santos CB,
      6. Silvan Scochi CG
      . Effects of breastfeeding on pain relief in full-term newborns. Clin J Pain. 2009;25(9):827–832pmid:19851165
      OpenUrlCrossRefPubMed
      1. Gray L,
      2. Miller LW,
      3. Philipp BL,
      4. Blass EM
      . Breastfeeding is analgesic in healthy newborns. Pediatrics. 2002;109(4):590–593pmid:11927701
      OpenUrlAbstract/FREE Full Text
      1. Gray L,
      2. Watt L,
      3. Blass EM
      . Skin-to-skin contact is analgesic in healthy newborns. Pediatrics. 2000;105(1). Available at: www.pediatrics.org/cgi/content/full/105/1/e14pmid:10617751
      OpenUrlAbstract/FREE Full Text
    14. ↵
      1. Prasopkittikun T,
      2. Tilokskulchai F
      . Management of pain from heel stick in neonates: an analysis of research conducted in Thailand. J Perinat Neonatal Nurs. 2003;17(4):304–312pmid:14655790
      OpenUrlPubMed
    15. ↵
      1. Campos RG
      . Soothing pain-elicited distress in infants with swaddling and pacifiers. Child Dev. 1989;60(4):781–792pmid:2758876
      OpenUrlCrossRefPubMed
    16. ↵
      1. O’Sullivan A,
      2. O’Connor M,
      3. Brosnahan D,
      4. McCreery K,
      5. Dempsey EM
      . Sweeten, soother and swaddle for retinopathy of prematurity screening: a randomised placebo controlled trial. Arch Dis Child Fetal Neonatal Ed. 2010;95(6):F419–F422pmid:20876596
      OpenUrlAbstract/FREE Full Text
    17. ↵
      1. Chambers CT,
      2. Taddio AT,
      3. Uman LS,
      4. McMurtry CM,
      5. HELPinKIDS Team
      . Psychological interventions for reducing pain and distress during routine childhood immunizations: a systematic review. Clin Ther. 2009;31(suppl 2):S77–S103pmid:19781437
      OpenUrlCrossRefPubMed
    18. ↵
      1. Shah PS,
      2. Aliwalas L,
      3. Shah V
      . Breastfeeding or breastmilk to alleviate procedural pain in neonates: a systematic review. Breastfeed Med. 2007;2(2):74–82pmid:17661578
      OpenUrlCrossRefPubMed
      1. Carbajal R,
      2. Veerapen S,
      3. Couderc S,
      4. Jugie M,
      5. Ville Y
      . Analgesic effect of breast feeding in term neonates: randomised controlled trial. BMJ. 2003;326(7379):13pmid:12511452
      OpenUrlAbstract/FREE Full Text
    19. ↵
      1. Sahebihagh MH,
      2. Hosseinzadeh M,
      3. Mohammadpourasl A,
      4. Kosha A
      . The effect of breastfeeding, oral sucrose and combination of oral sucrose and breastfeeding in infant’s pain relief during vaccination. Iran J Nurs Midwifery Res. 2011;16(1):1–7pmid:21772915
      OpenUrlPubMed
    20. ↵
      1. Karp H
      . The Happiest Baby on the Block. New York, NY: Bantam Books; 2003
    21. ↵
      1. Taddio A,
      2. Ilersich AL,
      3. Ipp M,
      4. Kikuta A,
      5. Shah V,
      6. HELPinKIDS Team
      . Physical interventions and injection techniques for reducing injection pain during routine childhood immunizations: systematic review of randomized controlled trials and quasi-randomized controlled trials. Clin Ther. 2009;31(suppl 2):S48–S76pmid:19781436
      OpenUrlCrossRefPubMed
    22. ↵
      1. Schade JG,
      2. Joyce BA,
      3. Gerkensmeyer J,
      4. Keck JF
      . Comparison of three preverbal scales for postoperative pain assessment in a diverse pediatric sample. J Pain Symptom Manage. 1996;12(6):348–359pmid:8973044
      OpenUrlCrossRefPubMed
    23. ↵
      1. Barr RG,
      2. Quek VS,
      3. Cousineau D,
      4. Oberlander TF,
      5. Brian JA,
      6. Young SN
      . Effects of intra-oral sucrose on crying, mouthing and hand-mouth contact in newborn and six-week-old infants. Dev Med Child Neurol. 1994;36(7):608–618pmid:8034123
      OpenUrlPubMed
    24. ↵
      1. Harrison D,
      2. Loughnan P,
      3. Manias E,
      4. Gordon I,
      5. Johnston L
      . Repeated doses of sucrose in infants continue to reduce procedural pain during prolonged hospitalizations. Nurs Res. 2009;58(6):427–434pmid:19918153
      OpenUrlCrossRefPubMed
    25. ↵
      1. Johnston CC,
      2. Stremler R,
      3. Horton L,
      4. Friedman A
      . Effect of repeated doses of sucrose during heel stick procedure in preterm neonates. Biol Neonate. 1999;75(3):160–166pmid:9925903
      OpenUrlCrossRefPubMed
    26. ↵
      1. McGrath PA
      . Pain in Children: Nature, Assessment, and Treatment. New York, NY: Guilford Press; 1990
    27. ↵
      1. Blass EM
      . Milk-induced hypoalgesia in human newborns. Pediatrics. 1997;99(6):825–829pmid:9164777
      OpenUrlAbstract/FREE Full Text
    28. ↵
      1. Allen KD,
      2. White DD,
      3. Walburn JN
      . Sucrose as an analgesic agent for infants during immunization injections. Arch Pediatr Adolesc Med. 1996;150(3):270–274pmid:8603220
      OpenUrlCrossRefPubMed
    29. ↵
      Poulsen M. Cane sugar unsuitable for use as analgesic in paediatric vaccination. Dan J Nurs 2009;106:54–57
    • Copyright © 2012 by the American Academy of Pediatrics
    PreviousNext
    Back to top

    Advertising Disclaimer »

    In this issue

    Pediatrics
    Vol. 129, Issue 5
    1 May 2012
    • Table of Contents
    • Index by author
    View this article with LENS
    PreviousNext
    Email Article

    Thank you for your interest in spreading the word on American Academy of Pediatrics.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Effective Analgesia Using Physical Interventions for Infant Immunizations
    (Your Name) has sent you a message from American Academy of Pediatrics
    (Your Name) thought you would like to see the American Academy of Pediatrics web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Request Permissions
    Article Alerts
    Log in
    You will be redirected to aap.org to login or to create your account.
    Or Sign In to Email Alerts with your Email Address
    Citation Tools
    Effective Analgesia Using Physical Interventions for Infant Immunizations
    John W. Harrington, Stacey Logan, Courtney Harwell, Jessica Gardner, Jessica Swingle, Erin McGuire, Rosemarie Santos
    Pediatrics May 2012, 129 (5) 815-822; DOI: 10.1542/peds.2011-1607

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Effective Analgesia Using Physical Interventions for Infant Immunizations
    John W. Harrington, Stacey Logan, Courtney Harwell, Jessica Gardner, Jessica Swingle, Erin McGuire, Rosemarie Santos
    Pediatrics May 2012, 129 (5) 815-822; DOI: 10.1542/peds.2011-1607
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    Print
    Download PDF
    Insight Alerts
    • Table of Contents

    Jump to section

    • Article
      • Abstract
      • Methods
      • Results
      • Discussion
      • Conclusions
      • Acknowledgments
      • Footnotes
      • References
    • Figures & Data
    • Info & Metrics
    • Comments

    Related Articles

    • No related articles found.
    • PubMed
    • Google Scholar

    Cited By...

    • Sugar and warmth additively decrease pain in newborns getting vaccines
    • Google Scholar

    More in this TOC Section

    • Health Services Use by Children in the Welfare System Who Died by Suicide
    • Differences in Lifetime Earning Potential for Pediatric Subspecialists
    • Changes in Family Poverty Status and Child Health
    Show more Article

    Similar Articles

    Subjects

    • Infectious Disease
      • Infectious Disease
      • Vaccine/Immunization
    • Journal Info
    • Editorial Board
    • Editorial Policies
    • Overview
    • Licensing Information
    • Authors/Reviewers
    • Author Guidelines
    • Submit My Manuscript
    • Open Access
    • Reviewer Guidelines
    • Librarians
    • Institutional Subscriptions
    • Usage Stats
    • Support
    • Contact Us
    • Subscribe
    • Resources
    • Media Kit
    • About
    • International Access
    • Terms of Use
    • Privacy Statement
    • FAQ
    • AAP.org
    • shopAAP
    • Follow American Academy of Pediatrics on Instagram
    • Visit American Academy of Pediatrics on Facebook
    • Follow American Academy of Pediatrics on Twitter
    • Follow American Academy of Pediatrics on Youtube
    • RSS
    American Academy of Pediatrics

    © 2021 American Academy of Pediatrics