PURPOSE OF THE STUDY.
Filaggrin coding gene (FLG) loss-of-function variants lead to skin-barrier dysfunction and have been associated with atopic dermatitis. These researchers sought to find associations between FLG variants and development of asthma, eczema, and sensitization to foods and aeroallergens in a high-risk birth cohort.
A total of 411 infants born to mothers with a history of asthma were followed longitudinally for a 5-year period with follow-up visits at least every 6 months. Asthma, eczema, and sensitization to allergens were diagnosed …