Clinical Disease Caused by Klebsiella in 2 Unrelated Patients With Interleukin 12 Receptor β1 Deficiency
PURPOSE OF THE STUDY.
To describe a new infectious disease phenotype in patients who inherit mutations in the interleukin 12 (IL-12) signaling pathway.
In this report the authors documented sepsis with Klebsiella pneumoniae in 2 unrelated patients with complete defects in the IL-12 receptor β1.
This was a chart review with case reports.
The first patient was born to unrelated parents and developed BCGitis after BCG vaccination in infancy followed by nontyphoidal salmonellosis. Both infections were …