PURPOSE OF THE STUDY.
The gene that encodes microsomal epoxide hydroxylase, (EPHX1, is responsible for detoxification of reactive epoxides to generate reactive oxygen species. The different polymorphisms influence EPHX1 activity. The associations of EPHX1 Tyr113His and His139Arg genotypes and diplotypes with asthma and wheezing outcomes were examined with a focus on the functional genetic change in glutathione S-transferase m1 (GSTM1) genotypes.
The study included 3741 7th-grade schoolchildren from 14 communities enrolled in the Taiwan Children Health Study.
Asthma and wheeze status …