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American Academy of Pediatrics
Case Report

Sibling Transmission of Vaccine-Derived Rotavirus (RotaTeq) Associated With Rotavirus Gastroenteritis

Daniel C. Payne, Kathryn M. Edwards, Michael D. Bowen, Erin Keckley, Jody Peters, Mathew D. Esona, Elizabeth N. Teel, Diane Kent, Umesh D. Parashar and Jon R. Gentsch
Pediatrics February 2010, 125 (2) e438-e441; DOI: https://doi.org/10.1542/peds.2009-1901
Daniel C. Payne
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Kathryn M. Edwards
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Michael D. Bowen
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Erin Keckley
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Jody Peters
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Mathew D. Esona
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Elizabeth N. Teel
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Diane Kent
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Umesh D. Parashar
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Jon R. Gentsch
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Abstract

Although rotavirus vaccines are known to be shed in stools, transmission of vaccine-derived virus to unvaccinated contacts resulting in symptomatic rotavirus gastroenteritis has not been reported to our knowledge. We document here the occurrence of vaccine-derived rotavirus (RotaTeq [Merck and Co, Whitehouse Station, NJ]) transmission from a vaccinated infant to an older, unvaccinated sibling, resulting in symptomatic rotavirus gastroenteritis that required emergency department care. Results of our investigation suggest that reassortment between vaccine component strains of genotypes P7[5]G1 and P1A[8]G6 occurred during replication either in the vaccinated infant or in the older sibling, raising the possibility that this reassortment may have increased the virulence of the vaccine-derived virus. Both children remain healthy 11 months after this event and are without underlying medical conditions.

  • rotavirus
  • acute gastroenteritis
  • RotaTeq
  • rotavirus vaccine
  • WC3
  • sibling transmission
  • horizontal transmission
  • shedding
  • reassortant
  • New Vaccine Surveillance Network
  • NVSN
  • Accepted November 20, 2009.
  • Copyright © 2010 by the American Academy of Pediatrics

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Pediatrics
Vol. 125, Issue 2
1 Feb 2010
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Sibling Transmission of Vaccine-Derived Rotavirus (RotaTeq) Associated With Rotavirus Gastroenteritis
Daniel C. Payne, Kathryn M. Edwards, Michael D. Bowen, Erin Keckley, Jody Peters, Mathew D. Esona, Elizabeth N. Teel, Diane Kent, Umesh D. Parashar, Jon R. Gentsch
Pediatrics Feb 2010, 125 (2) e438-e441; DOI: 10.1542/peds.2009-1901

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Sibling Transmission of Vaccine-Derived Rotavirus (RotaTeq) Associated With Rotavirus Gastroenteritis
Daniel C. Payne, Kathryn M. Edwards, Michael D. Bowen, Erin Keckley, Jody Peters, Mathew D. Esona, Elizabeth N. Teel, Diane Kent, Umesh D. Parashar, Jon R. Gentsch
Pediatrics Feb 2010, 125 (2) e438-e441; DOI: 10.1542/peds.2009-1901
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  • Multiple Introductions and Antigenic Mismatch with Vaccines May Contribute to Increased Predominance of G12P[8] Rotaviruses in the United States
  • Monitoring Shedding of Five Genotypes of RotaTeq Vaccine Viruses by Genotype-Specific Real-Time Reverse Transcription-PCR Assays
  • Analysis of Human Rotaviruses from a Single Location Over an 18-Year Time Span Suggests that Protein Coadaption Influences Gene Constellations
  • Safety of Rotavirus Vaccine in the NICU
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