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Discover Pediatric Collections on COVID-19 and Racism and Its Effects on Pediatric Health

American Academy of Pediatrics
Article

Empyema Hospitalizations Increased in US Children Despite Pneumococcal Conjugate Vaccine

Su-Ting T. Li and Daniel J. Tancredi
Pediatrics January 2010, 125 (1) 26-33; DOI: https://doi.org/10.1542/peds.2009-0184
Su-Ting T. Li
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Daniel J. Tancredi
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This article has a correction. Please see:

  • Li S-TT and Tancredi DJ. Empyema Hospitalizations Increased in US Children Despite Pneumococcal Conjugate Vaccine. Pediatrics. 2010;125(1):26–33 - February 01, 2010

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Abstract

OBJECTIVE: To determine if the incidence of empyema among children in the United States has changed since the introduction of the pneumococcal conjugate vaccine in 2000.

METHODS: We used the nationally representative Kids' Inpatient Database to estimate the annual total number of hospitalizations of children ≤18 years of age that were associated with empyema in 1997, 2000, 2003, and 2006. Using US Census data, estimated counts were converted into annual incidence rates per 100000 children. Incidence rates were compared between 1997 and later years to determine the impact of pneumococcal conjugate vaccine on hospitalization rates.

RESULTS: During 2006, an estimated total of 2898 (95% confidence interval [CI]: 2532–3264) hospitalizations of children ≤18 years of age in the United States were associated with empyema. The empyema-associated hospitalization rate was estimated at 3.7 (95% CI: 3.3–4.2) per 100000 children, an increase of almost 70% from the 1997 empyema hospitalization rate of 2.2 (95% CI: 1.9–2.5) per 100000. The rate of complicated pneumonia (empyema, pleural effusion, or bacterial pneumonia requiring a chest tube or decortication) similarly increased 44%, to 5.5 (95% CI: 4.8–6.1) per 100000. The rate of bacterial pneumonia decreased 13%, to 244.3 (95% CI: 231.1–257.5) per 100000. The rate of invasive pneumococcal disease (pneumonia, sepsis, or meningitis caused by Streptococcus pneumoniae) decreased 50%, to 6.3 (95% CI: 5.7–6.9) per 100000.

CONCLUSIONS: Among children ≤18 years of age, the annual empyema-associated hospitalization rates increased almost 70% between 1997 and 2006, despite decreases in the bacterial pneumonia and invasive pneumococcal disease rates. Pneumococcal conjugate vaccine is not decreasing the incidence of empyema.

  • empyema
  • epidemiology
  • heptavalent pneumococcal conjugate vaccine
  • pneumococcal infections
  • pneumonia
  • pneumococcal
  • adolescent
  • child
  • preschool
  • infant
  • retrospective studies
  • United States
  • Accepted July 9, 2009.
  • Copyright © 2010 by the American Academy of Pediatrics

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Pediatrics
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January 2010
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Empyema Hospitalizations Increased in US Children Despite Pneumococcal Conjugate Vaccine
Su-Ting T. Li, Daniel J. Tancredi
Pediatrics Jan 2010, 125 (1) 26-33; DOI: 10.1542/peds.2009-0184

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Empyema Hospitalizations Increased in US Children Despite Pneumococcal Conjugate Vaccine
Su-Ting T. Li, Daniel J. Tancredi
Pediatrics Jan 2010, 125 (1) 26-33; DOI: 10.1542/peds.2009-0184
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  • Li S-TT and Tancredi DJ. Empyema Hospitalizations Increased in US Children Despite Pneumococcal Conjugate Vaccine. Pediatrics. 2010;125(1):26–33
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