Chromosomal map of human linkage to associated genes for asthma. The 95% confidence intervals of human quantitative trait loci are shown as blue bars to the left of their respective chromosomes, with the peaks indicated by black lines. The specific genes associated with asthma are identified to the right of each chromosome.
Chromosomal map of human quantitative trait loci (QTL) for asthma and BHR and mouse concordant regions. The 95% confidence intervals of the human quantitative trait loci are shown as blue bars to left of their respective chromosomes, with the peaks indicated by black lines. Mouse asthma quantitative trait loci that are concordant with human quantitative trait loci are shown in orange to the right of each chromosome, with the mouse chromosome and the position given in parentheses. Chromosomes are drawn to scale on the basis of the length of each chromosome from the Human Genome Browser (www.ensembl.org/Homo_sapiens). Because many human studies did not report the confidence intervals or the names of the markers that flank the intervals, determining accurate confidence intervals is difficult. This map shows conservative confidence intervals that were generated by including a region of 15 million base pairs both upstream and downstream of the peak.
Fine detailed maps of mouse chromosomes 7 (A) and 13 (B). These maps were generated with 3 sets of data, leading to target areas that satisfy the best conditions for containing candidate genes of interest. Each map shows the mouse chromosome with 95% confidence intervals of the quantitative trait loci (QTL), shown as green horizontal bars; within these intervals, the peaks are shown in red. The regions that should be considered further are those that are not homologous by descent between the strains of mice that generated the quantitative trait loci. For example, for chromosome 7, the regions that are of further interest are the regions that differ between C3H and A/J (indicated by yellow bars in A). Taking into account the regions that contain concordant human quantitative trait loci (shown as blue bars), the black bars indicate optimal target areas.