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In Reply.—
In response to our clinical trial report,1 Rowland et al raised concerns about sample size, examination of height velocity, choice of control group, and need for replication. We welcome discussion about advancing behavioral science studies that aim to improve health outcomes in pediatric populations and agree that this type of clinical investigation poses potential benefits to children with cystic fibrosis (CF) and their families while also presenting challenges to scientist-practitioners. Indeed, results of a single clinical trial study can never provide evidence of generalizability or replication, and decisions made in the process of designing and executing a clinical trial necessitate trade-offs and compromises. In our report, we acknowledged and discussed (and proposed future directions …
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