Ophthalmologic Examinations in Children With Juvenile Rheumatoid Arthritis

Articular Features

The classification of JRA describes a heterogeneous group of disorders of predominantly peripheral arthritis with onset of disease before 16 years of age. The 3 major onset types defined by clinical manifestations in the first 6 months of the disease are oligoarticular (pauciarticular), polyarticular, and systemic.¹¹ The onset type is determined by the systemic features of the illness and the number of joints with arthritis at diagnosis. Oligoarticular JRA is defined by involvement of 4 or fewer joints; polyarticular JRA is defined by involvement of >4 joints (usually 10–20); and systemic-onset JRA is defined by quotidian fevers during the first 6 weeks of the illness, almost always associated with a characteristic rash. Less than 1% of children with systemic-onset JRA develop chronic uveitis.^5,7 Most children with uveitis have an oligoarticular onset.^1,2,7

Chronic uveitis may be detected at the time of initial diagnosis of arthritis; however, if not present at onset, it most often presents during the next 4 to 7 years.^7,12 The period of highest risk is within 4 years of onset of arthritis, although the risk is never entirely absent.^7,12 Eye involvement precedes involvement of the joints in approximately 5% of cases.

Children with JRA remain at risk of developing uveitis into adulthood. There are reports of uveitis diagnosed initially more than 20 years after onset of arthritis.¹³ The activity of the uveal inflammation does not parallel that of the joint disease.^14,15

Age

Children at greatest risk of developing uveitis are those with oligoarticular-onset JRA.^1,2,13 The peak age of onset of arthritis in oligoarthritis is 1 to 5 years.¹²

Immunogenetic and Serologic Markers

The serologic marker most strongly associated with chronic uveitis is the presence of antinuclear antibodies.^1,2,16 Antinuclear antibodies are present in 65% to 90% of children with chronic uveitis and are a major risk factor for its development.^7,17 They are usually detected in low to moderate titers on HEp-2 cells and are of unknown antigenic specificity. Rheumatoid factor is not usually present in children with JRA, including those with uveitis. Immunogenetic factors may predispose to the development of chronic uveitis. The associated alleles are located predominantly in the major histocompatibility complex (MHC) region on chromosome 6 and involve specificities in the HLA-DR, DP, and DQ regions.¹⁸

Clinical Characteristics

The onset of ocular inflammation is insidious and asymptomatic in most young children.^1,2,17 Because of the lack of symptoms or the cognitive recognition by the child, the exact time of onset of ocular involvement is frequently difficult to determine. This observation emphasizes the requirement for slit-lamp examination by an ophthalmologist at diagnosis of JRA and periodically thereafter.

Signs or symptoms in older children, rare as they are, may include a red eye, decreased vision, unequal pupils, ocular pain, and headaches and should prompt an urgent eye examination. Most cases of uveitis are bilateral (70% to 80%); unilateral disease may progress to bilateral involvement.

Data compiled before widespread therapy with methotrexate and tumor necrosis factor blockers indicated that the prognosis was good in 25% of cases, and 25% of children responded poorly to treatment and/or might require surgery for cataracts or glaucoma.³ Approximately 50% of patients required prolonged treatment for moderate to severe chronic inflammation; the visual prognosis in these patients remained guarded. Early and aggressive treatment of intraocular inflammation has helped to reduce the morbidity of the ocular disease.¹⁹