Niimi A, Matsumoto H, Amitami R, et al. Am J Med. 2004;116:725–731
Purpose of the Study.
To examine the effect of inhaled corticosteroids (ICSs) on thickening of the asthmatic airway wall as measured by computed tomography (CT), pulmonary function, and serum levels of eosinophilic cationic protein (ECP).
Fifty-one patients (mean age: 54.4 ± 13.8 years) with persistent asthma and 28 healthy controls (mean age: 48.1 ± 15.9 years).
Patients fulfilled American Thoracic Society criteria for asthma, and none had ever received systemic or inhaled steroids, cromomes, or antileukotriene agents. Exclusion criteria …