Dahl ME, Dabbagh K, Liggitt D, Kim S, Lewis DB. Nat Immunol. 2004;5:337–343
Purpose of the Study.
To determine the role of interferon (IFN)-γ and dendritic cells in allergic pulmonary disease after influenza A infection.
IFN-γ knockout and wild-type mice completely recovered from influenza A infection were studied.
Mice were inoculated intranasally with influenza A virus. The postinfluenza mice were then sensitized and challenged with allergen. Airway inflammatory cells, specific antibody responses, and pulmonary dendritic cell functions were examined. In some …