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Toxic mechanisms of liver injury.
Developmental Changes in Hepatic Metabolism, Biotransformation, and Enterohepatic Circulation
UGT indicates uridine diphosphate glucuronyl transferase; NAT2, N-acetyltransferase 2.
Pathologic and Biochemical Changes in Environmental Toxin–Induced Injury
Modified from Zimmerman.19
HTN indicates hypertension; HCC, hepatocellular carcinoma; AST, aspartate aminotransferase; V×, variable; CCl4, carbon tetrachloride; Adol, adolescents; OE, occupational exposure.
↵* Expressed as times (×) upper limit of normal.
Clinical and Pathologic Findings in Drug-Induced Liver Disease in Children
6-MP indicates 6-mercaptopurine; SLE, systemic lupus erythematosus; TMT-SMX, trimethoprim-sulfamethoxazole.
↵* Drugs most commonly reported to cause hepatotoxicity in children.
↵† Expressed as times (×) upper limit of normal.
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