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To the Editor.—
We read with interest the report of Sarici et al1 on their success in predicting subsequent hyperbilirubinemia by performing first- day serum bilirubin determinations in ABO-incompatible neonates. Although the incidence of hyperbilirubinemia of 21.3% is perhaps not surprising in an ABO-incompatible cohort, the authors also note that, in a previous study in the same population group, the incidence of hyperbilirubinemia in their general neonatal population was as high as 12.05%.2 Of note was the observation that a significant risk factor for hyperbilirubinemia among the ABO-incompatible neonates was a sibling with neonatal jaundice.
It is surprising that although in both studies glucose-6-phosphate dehydrogenase (G-6-PD) deficiency was screened for routinely, the results of this screening were not provided. G-6-PD deficiency may result in an incidence of neonatal hyperbilirubinemia several times higher that of G-6-PD-normal counterparts.3 Furthermore, G-6-PD deficiency may result in rates of neonatal bilirubin production …
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