Skip to main content

Advertising Disclaimer »

Main menu

  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers
  • Other Publications
    • American Academy of Pediatrics

User menu

  • Log in

Search

  • Advanced search
American Academy of Pediatrics

AAP Gateway

Advanced Search

AAP Logo

  • Log in
  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Open Access
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Blogs
    • Topic/Program Collections
    • AAP Meeting Abstracts
  • Pediatric Collections
    • COVID-19
    • Racism and Its Effects on Pediatric Health
    • More Collections...
  • AAP Policy
  • Supplements
  • Multimedia
    • Video Abstracts
    • Pediatrics On Call Podcast
  • Subscribe
  • Alerts
  • Careers

Discover Pediatric Collections on COVID-19 and Racism and Its Effects on Pediatric Health

American Academy of Pediatrics
EXPERIENCE AND REASON

Involuntary Movements and Magnetic Resonance Imaging Findings in Infantile Cobalamine (Vitamin B12) Deficiency

Zekai Avci, Tuba Turul, Sabiha Aysun and Işıil Ünal
Pediatrics September 2003, 112 (3) 684-686; DOI: https://doi.org/10.1542/peds.112.3.684
Zekai Avci
Department of Pediatrics Fatih University School of Medicine Ankara, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tuba Turul
Department of Pediatrics Hacettepe University School of Medicine Ankara, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sabiha Aysun
Department of Pediatrics Hacettepe University School of Medicine Ankara, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Işıil Ünal
Department of Neurology Hacettepe University School of Medicine Ankara, Turkey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Comments
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Download PDF

Infantile vitamin B12 (vit B12) deficiency is encountered in malnourished infants or in offspring of strict vegan mothers or mothers with pernicious anemia and accompanied by hematologic and neurologic findings. We present here a 16-month-old infant whose mother had vit B12 deficiency with low socioeconomic level admitted to our hospital. On admission, the patient was apathic, hypotonic, and lethargic. Serum vit B12 level was below detectable limits. On cranial magnetic resonance imaging (MRI), T2-weighted images revealed bilateral frontal and parietal periventricular high-signal symmetric lesions in the white matter (delayed myelination) and frontoparietal cortical atrophy. On day 3 of vit B12 therapy, involuntary movements were observed.

Vit B12 is an essential vitamin and needs to be supplied by diet. Although a vit B12-deficient diet can be tolerated by the adults for years from the endogenous pool, deficiency in infants may become symptomatic in a few months because of the limited hepatic reserve.1 Infantile vit B12 deficiency is common in malnourished offspring of vegan mothers and mothers with pernicious anemia and has a clinical course of ineffective hematopoiesis and neurodegenerative signs.1–5 Here, we present a 16-month-old male infant who had severe vit B12 deficiency accompanied by hematologic, neurologic, and typical MRI findings.

CASE REPORT

A 16-month-old male infant was admitted to our hospital for fever and tendency to sleep. His past medical history revealed that his mental and motor development were normal up to 8 months of age. He subsequently became lethargic and showed developmental regression. He was hospitalized for irritability and …

Reprint requests to (Z.A.) Department of Pediatrics, Fatih University School of Medicine, Alparslan Türkeþ cad. No: 57, 06510, Beþtepe, Ankara, Turkey. E-mail: zekaiavci{at}yahoo.com

Individual Login

Log in
You will be redirected to aap.org to login or to create your account.

Institutional Login

via Institution

You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.

Log in through your institution

If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

Pay Per Article - You may access this article (from the computer you are currently using) for 2 days for US$25.00

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Offer Reprints

PreviousNext
Back to top

Advertising Disclaimer »

In this issue

Pediatrics
Vol. 112, Issue 3
1 Sep 2003
  • Table of Contents
  • Index by author
View this article with LENS
PreviousNext
Email Article

Thank you for your interest in spreading the word on American Academy of Pediatrics.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Involuntary Movements and Magnetic Resonance Imaging Findings in Infantile Cobalamine (Vitamin B12) Deficiency
(Your Name) has sent you a message from American Academy of Pediatrics
(Your Name) thought you would like to see the American Academy of Pediatrics web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Request Permissions
Article Alerts
Log in
You will be redirected to aap.org to login or to create your account.
Or Sign In to Email Alerts with your Email Address
Citation Tools
Involuntary Movements and Magnetic Resonance Imaging Findings in Infantile Cobalamine (Vitamin B12) Deficiency
Zekai Avci, Tuba Turul, Sabiha Aysun, Işıil Ünal
Pediatrics Sep 2003, 112 (3) 684-686; DOI: 10.1542/peds.112.3.684

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Involuntary Movements and Magnetic Resonance Imaging Findings in Infantile Cobalamine (Vitamin B12) Deficiency
Zekai Avci, Tuba Turul, Sabiha Aysun, Işıil Ünal
Pediatrics Sep 2003, 112 (3) 684-686; DOI: 10.1542/peds.112.3.684
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Print
Download PDF
Insight Alerts
  • Table of Contents

Jump to section

  • Article
    • CASE REPORT
    • DISCUSSION
    • CONCLUSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • Comments

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Neuro-regression in vitamin B12 deficiency
  • In utero physiology: role of folic acid in nutrient delivery and fetal development
  • Google Scholar

More in this TOC Section

  • Invasive Pulmonary and Central Nervous System Aspergillosis After Near-Drowning of a Child: Case Report and Review of the Literature
  • Intracranial Hemorrhage as the Initial Manifestation of a Congenital Disorder of Glycosylation
  • Thoracolumbar Syrinx in Association With Williams Syndrome
Show more EXPERIENCE AND REASON

Similar Articles

Subjects

  • Neurology
    • Neurology

Keywords

  • EMG, electromyography
  • Ig, immunoglobulin
  • MRI, magnetic resonance imaging
  • vit B12, vitamin B12
  • Journal Info
  • Editorial Board
  • Editorial Policies
  • Overview
  • Licensing Information
  • Authors/Reviewers
  • Author Guidelines
  • Submit My Manuscript
  • Open Access
  • Reviewer Guidelines
  • Librarians
  • Institutional Subscriptions
  • Usage Stats
  • Support
  • Contact Us
  • Subscribe
  • Resources
  • Media Kit
  • About
  • International Access
  • Terms of Use
  • Privacy Statement
  • FAQ
  • AAP.org
  • shopAAP
  • Follow American Academy of Pediatrics on Instagram
  • Visit American Academy of Pediatrics on Facebook
  • Follow American Academy of Pediatrics on Twitter
  • Follow American Academy of Pediatrics on Youtube
  • RSS
American Academy of Pediatrics

© 2021 American Academy of Pediatrics