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American Academy of Pediatrics
Article

Serological Screening for Celiac Disease in Healthy 2.5-Year-Old Children in Sweden

Anneli K. Carlsson, Irene E. M. Axelsson, Stefan K. Borulf, Anders C. A. Bredberg and Sten-A. Ivarsson
Pediatrics January 2001, 107 (1) 42-45; DOI: https://doi.org/10.1542/peds.107.1.42
Anneli K. Carlsson
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Irene E. M. Axelsson
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Stefan K. Borulf
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Anders C. A. Bredberg
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Sten-A. Ivarsson
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Abstract

Objective. The study was designed to investigate the prevalence of celiac disease (CD) among 2.5-year-old children in a Swedish urban population with a high incidence of CD.

Material and Methods. Six hundred ninety apparently healthy children, born in the 12-month period of July 1992 through June 1993, were screened for immunoglobulin A (IgA) antigliadin antibodies and IgA antiendomysium antibodies, and those antibody-positive at repeated testing were further investigated with intestinal biopsy.

Results. Of the 690 children, 6 were both IgA antigliadin antibody- and IgA antiendomysium antibody-positive, and 7 were antiendomysium antibody-positive but antigliadin antibody-negative. Jejunal biopsy, performed in 12 cases, manifested partial or total villous atrophy in 8 cases. Thus, together with an additional child whose parents declined the offered biopsy, but whose response to a gluten-free diet confirmed the presence of CD, the prevalence of CD in the study series was 1.3% (9/690; 95% confidence interval: .4–2.2). However, independent of the study, an additional 22 cases of symptomatic, biopsy-verified CD have already been detected in the birth cohort of 3004 children.

Conclusions. The prevalence of CD in our study series was high, at least 1.0%, but may be as high as 2.0% if the frequency of silent CD is as high as we have found in the remaining unscreened cohort. These findings confirm that CD is one of the most common chronic disorders.

  • celiac disease
  • immunoglobulin A antigliadin antibodies
  • immunoglobulin A antiendomysium antibodies
  • Received November 18, 1999.
  • Accepted May 24, 2000.
  • Copyright © 2001 American Academy of Pediatrics

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Pediatrics
Vol. 107, Issue 1
1 Jan 2001
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Serological Screening for Celiac Disease in Healthy 2.5-Year-Old Children in Sweden
Anneli K. Carlsson, Irene E. M. Axelsson, Stefan K. Borulf, Anders C. A. Bredberg, Sten-A. Ivarsson
Pediatrics Jan 2001, 107 (1) 42-45; DOI: 10.1542/peds.107.1.42

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Serological Screening for Celiac Disease in Healthy 2.5-Year-Old Children in Sweden
Anneli K. Carlsson, Irene E. M. Axelsson, Stefan K. Borulf, Anders C. A. Bredberg, Sten-A. Ivarsson
Pediatrics Jan 2001, 107 (1) 42-45; DOI: 10.1542/peds.107.1.42
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