This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
To the Editor.
I read with interest the article by Dr Kessel et al,1 in which they describe a case of nonimmune hydrops fetalis in an infant subsequently diagnosed to have congenital hypothyroidism. No other cause was identified and the hypothyroidism was thought to have led to hydrops fetalis by reducing the adrenergic stimulation of the lymphatic system, resulting in chylothorax. In our study of the neonatal screening program of 15 000 neonates for congenital hypothyroidism, we diagnosed 3 cases of primary hypothyroidism (prevalence 1/5060 births). Hypothyroxinemia was diagnosed in another 5 who died in the immediate neonatal period, 2 of whom had nonimmune hydrops fetalis but no chylothorax.2One had thoracic dystrophy, omphalocele, abnormal vertebrae, and dislocated hips in association with hydrops fetalis. The other had no other associated malformations. No immune, hematologic, cardiac, or placental anomalies were identified in any of these infants, and none of their mothers had any thyroid problem. Cord blood thyroxine levels were 3.9 and 5.0 μg/dL …
Individual Login
Institutional Login
You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.
Log in through your institution
Pay Per Article - You may access this article (from the computer you are currently using) for 2 days for US$25.00
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
In this issue
