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American Academy of Pediatrics
Article

Vagal Nerve Stimulation in Epileptic Encephalopathies

Alasdair P. J. Parker, Charles E. Polkey, Colin D. Binnie, Catherine Madigan, Colin D. Ferrie and Richard O. Robinson
Pediatrics April 1999, 103 (4) 778-782; DOI: https://doi.org/10.1542/peds.103.4.778
Alasdair P. J. Parker
From the *Newcomen Centre, Guy's Hospital, London, United Kingdom; the Departments of
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Charles E. Polkey
‡Neurosurgery and
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Colin D. Binnie
§Clinical Neurophysiology, King's College Hospital, London, United Kingdom; and the
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Catherine Madigan
From the *Newcomen Centre, Guy's Hospital, London, United Kingdom; the Departments of
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Colin D. Ferrie
‖Department of Paediatric Neurology, Leeds General Infirmary, Leeds, United Kingdom.
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Richard O. Robinson
From the *Newcomen Centre, Guy's Hospital, London, United Kingdom; the Departments of
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Abstract

Objective. To study the effect of vagal nerve stimulation (VNS) in children with epileptic encephalopathies.

Methods and Materials. All children receiving VNS during a 2-year period at our center were studied prospectively for changes in seizure frequency, electroencephalogram (EEG), adaptive behavior, quality of life, and where appropriate, verbal/nonverbal performance. Assessments were made before and for at least 1 year after implant.

Results. Sixteen children were studied. One device was removed because of infection. Of the remaining 15 children, 4 had a >50% reduction and 2 had a >50% increase in seizure frequency at 1 year after implant. Median reduction in seizure frequency was 17%. There was no trend toward improvement of the EEG or adaptive behavior. Quality of life was unchanged in most areas, except in perceived treatment side effects and general behavior that were improved. In 6 children undergoing further assessment, there was a significant improvement in verbal performance; this did not correlate with reduction in seizure frequency.

Conclusion. VNS did not significantly improve seizure frequency, severity, adaptive behavior, or the EEG during the first year of treatment for the group as a whole, although 4 children (27%) had a worthwhile reduction in seizure frequency. There were significant improvements in perceived treatment side effects and general behavior.

  • epilepsy
  • encephalopathy
  • vagal nerve stimulation
  • Received February 26, 1998.
  • Accepted September 21, 1998.
  • Copyright © 1999 American Academy of Pediatrics

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Pediatrics
Vol. 103, Issue 4
1 Apr 1999
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Vagal Nerve Stimulation in Epileptic Encephalopathies
Alasdair P. J. Parker, Charles E. Polkey, Colin D. Binnie, Catherine Madigan, Colin D. Ferrie, Richard O. Robinson
Pediatrics Apr 1999, 103 (4) 778-782; DOI: 10.1542/peds.103.4.778

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Vagal Nerve Stimulation in Epileptic Encephalopathies
Alasdair P. J. Parker, Charles E. Polkey, Colin D. Binnie, Catherine Madigan, Colin D. Ferrie, Richard O. Robinson
Pediatrics Apr 1999, 103 (4) 778-782; DOI: 10.1542/peds.103.4.778
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