TABLE 5

Use of MS/MS for Newborn Screening

By MS/MS OnlyBy MS/MS or Other TechniqueaNot By MS/MS
ArgininemiaCongenital adrenal hyperplasiaBiotinidase
Argininosuccinic acidemiaGalactosemiaCystic fibrosis
CitrullinemiaHemoglobinopathiesHearing loss
HypermethioninemiaHomocystinuriaHypothyroidism
Hyperornithinemia-hyperammonemia-homocitrullinuriaMaple syrup urine disease
FAO disorders (such as MCAD deficiency)PKU
Organic acidemiasTyrosinemia
  • This is not a comprehensive list of disorders for which newborn screening is possible.

  • a Most states use a method other than MS/MS to screen for these disorders.