TABLE 1.

Maternal Intrapartum and Infant Prophylactic Antiretroviral Drug Regimens When an HIV-1—Infected Mother Has Not Received Prenatal Antiretroviral Therapy

DrugMaternal Dosing, IntrapartumInfant DosingInfant Schedule
NVPSingle 200-mg dose PO at onset of labor2 mg/kg PO single doseSingle dose at 48–72 h
ZDV with 3TCZDV, 600 mg PO at onset of labor followed by 300 mg PO every 3 h until delivery; and 3TC, 150 mg PO at onset of labor followed by 150 mg PO every 12 h until deliveryZDV, 4 mg/kg PO every 12 h; and 3TC, 2 mg/kg PO every 12 hFor 1 wk
ZDV2 mg/kg, IV bolus followed by continuous infusion of 1 mg/kg per h until delivery2 mg/kg PO 4 times per dayBeginning 8–12 h after birth and continuing through 6 wk of age
If unable to tolerate oral therapy, 1.5 mg/kg IV every 6 h
If infant is preterm, 1.5 mg/kg every 12 hours for 2 weeks and then increase to 2 mg/kg every 8 h
ZDV with NVPZDV, 2 mg/kg IV bolus followed by continuous infusion of 1 mg/kg per h until delivery; and NVP, single 200-mg dose, PO, at onset of laborZDV, 2 mg/kg PO 4 times per day; and NVP, 2 mg/kg PO single doseStart ZDV beginning 8–12 h after birth and continuing through 6 wk of age; and single dose of NVP at 48–72 h of age
  • IV indicates intravenous; PO, oral.