TABLE 1

Meta-analyses of Surfactant Replacement: Prophylaxis and Rescue Treatment With Animal-Derived and Synthetic Surfactant2,3,8,11

OutcomeProphylactic SurfactantRescue Surfactant
Animal DerivedSyntheticAnimal DerivedSynthetic
N RR (95% CI)N RR (95% CI)N RR (95% CI)N RR (95% CI)
Neonatal mortality8 0.60 (0.47–0.77)7 0.70 (0.58–0.85)10 0.68 (0.57–0.82)6 0.73 (0.61–0.88)
Pneumothorax9 0.40 (0.29–0.54)6 0.67 (0.50–0.90)12 0.42 (0.34–0.52)5 0.64 (0.55–0.76)
PIE6 0.46 (0.36–0.59)2 0.68 (0.50–0.93)8 0.45 (0.37–0.55)4 0.62 (0.54–0.71)
BPDa8 0.91 (0.79–1.05)4 1.06 (0.83–1.36)12 0.95 (0.84–1.08)5 0.75 (0.61–0.92)
BPD/deatha8 0.80 (0.72–0.88)4 0.89 (0.77–1.03)12 0.83 (0.77–0.90)4 0.73 (0.65–0.83)
  • N, number; PIE, pulmonary interstitial emphysema.

  • a Defined at 28 d.