TABLE 3

Survival and Neurodevelopmental Outcomes of Infants Born at 22 and 23 Weeks’ Gestation From the Systematic Review

Study Name (Reference) (Location, Age at Follow-up, Year of Birth, Type of Study)22 Weeks23 Weeks24–27 Weeks
Mortality,an/Live Births (%)Evaluated, n/Survivors at 3 Years (%)Death or NDI, n/Study Cohort (%)Mortality,an/Live Births (%)Evaluated, n/Survivors at 3 Years (%)Death or NDI, n/Study Cohort (%)Mortality,an/Live Births (%)Evaluated, n/Survivors at 3 Years (%)Death or NDI, n/Study Cohort (%)
NICHD (7) (US, 18–24 mo, 2002–2004, multicenter)309/322 (96)342/441 (78)22–23 weeks; 104/112 (93)22–23 weeks; 750/763 (98)24 weeks; 294/632 (47)22–24 weeks; 405/450 (90)24 weeks; 489/632 (77)
VON (8) (US, 18–24 mo, 1998–2003, multicenter)<23 weeks; 504/528 (96)<23 weeks; 15/21 (71)<23 weeks; 515/528 (98)567/916 (62)214/298 (72)679/916 (74)24–25 weeks; 906/3033 (30)24–25 weeks; 1229/1702 (72)24–25 weeks; 1401/3033 (46)
Victoria (9,10) (Australia, 24 mo, 2005, population-based)32/33 (97)28/35 (80)24–27 weeks; 56/220 (25)22–27 weeks; 163/172 (95)22–27 weeks; 196/288 (68)
EPIBEL (11,12) (Belgium,30–42 mo, 1999–2000, population-based)28/28 (100)0/0 (0)28/28(100)40/41 (98)1/1(100)40/41 (98)24–26 weeks; 91/182 (50)24–26 weeks; 88/91 (97)24–26 weeks; 142/182 (78)
EPICure (13,14) (UK, 30 mo median, 1995, population-based)136/138 (99)2/2 (100)137/138(99)216/241 (90)25/25(100)230/241 (95)24–25 weeks; 525/806 (65)24–25 weeks; 279/281 (99)24–25 weeks; 661/806 (82)
EPIPAGE (15,16) (France, 24 mo, 1997, population-based)16/16 (100)0/0 (0)16/16(100)30/30 (100)0/0 (0)30/30 (100)24–27 weeks; 224/549 (41)
Essen (17) (Germany, 24–30 mo, 2000–2004, hospital-based)8/10 (80)2/2 (100)9/10(90)12/18 (67)5/6 (83)12/18(67)24–25 weeks; 16/55 (29)24–25 weeks; 34/39 (87)24–25 weeks; 22/55 (40)
ETFOL (18) (Denmark, 24 mo, 1994–1995, population-based)<24 weeks; 37/37 (100)<24 weeks; 0/0 (0)< 24 weeks; 37/37 (100)24–27 weeks; 154/349 (44)24–27 weeks; 183/195 (94)24–27 weeks; 206/349 (59)
Current study (Japan, 36 mo median, 2003–2005, multicenter)48/75 (64), 43/69 (62)b23/27 (85)60/75(80)91/245 (37), 82/225 (36)b119/154 (77)156/245 (64)24–25 weeks; 139/737 (19), 127/605(19)b24–25 weeks; 420/601 (70)24–25 weeks; 267/737 (36)
  • EPIBEL, Extremely Preterm Infants in Belgium Study Group; EPICure, study for all infants born before 26 completed weeks of gestational age in the United Kingdom and the Republic of Ireland in 1995; EPIPAGE, The Etude Epidémiologique sur les Petits Ages Gestationnels study; VON, Vermont Oxford Network; —, data was not shown.

  • a Mortality included cases who died in the delivery room, died in the NICU, or died after discharge until evaluation, but not cases who died intrapartum.

  • b Mortality excluding the infants transferred after birth to the participating centers from cases in footnote a.