TABLE 1

The Consensus Definitions of Outcomes

OutcomesCNNNRNJConsensus
MortalityDeath before last discharge from NICUDeath before last discharge from NICUDeath before last discharge from NICU
Severe neurologic injuryIVH with ventricular enlargement or persistent parenchymal echogenicity beyond 21 d or periventricular leukomalaciaIVH grade 3 or 4 or periventricular leukomalaciaIVH grade 3 or 4 or persistent parenchymal echogenicity beyond 21 d or periventricular leukomalacia
BPDOxygen use at 36 wk corrected GA or at the time of discharge to level 2 hospitalOxygen use at 36 wk corrected GA age with oxygen use on 28th day after birthOxygen use at 36 wk corrected GA with oxygen use on 28th day after birth
Severe ROPStage III or above (according to international classification)Grade 3 (middle, late) and above (according to Japanese grading of ROP)Stage 3 or higher (international classification) or grade 3 (middle, late) or higher
NECAccording to Bell criteria stage 2 or higherAccording to Bell criteria, stage 2 or higherAccording to Bell’s criteria, stage 2 or higher34
Late-onset sepsisSepsis at ≥3 d of lifeSepsis at ≥7 d of lifeSepsis at ≥7 d of life
PDAClinical or echocardiographic diagnosis of PDAClinical or echocardiographic diagnosis of PDAClinical or echocardiographic diagnosis of PDA