TABLE 2

Suggested Criteria for Prompting Molecular Testing for PWS

Age at AssessmentFeatures Sufficient to Prompt DNA Testing
Birth to 2 ySignificant hypotonia with poor suck and difficulty with weight gain
2–6 yCongenital hypotonia with history of poor suck; global developmental delay
6–12 yHistory of congenital hypotonia with poor suck (hypotonia often persists), global developmental delay, and excessive eating (hyperphagia; obsession with food) with central obesity if uncontrolled
13 y through adulthoodCognitive impairment, usually mild mental retardation, excessive eating (hyperphagia; obsession with food) with central obesity if uncontrolled, and hypothalamic hypogonadism and/or typical behavior problems (including temper tantrums and obsessive-compulsive features)