TABLE 2

Cumulative Exposure to Ethylmercury According to Exposure Period

Case/Control Comparison/Exposure PeriodCumulative Exposure Amount, μg
Case-ChildrenControls
MeanMinimumMaximumMeanMinimumMaximum
Case-children with ASD (n = 256) vs controls (n = 752)
    Prenatal2.70074.002.350100.00a
    Birth to 1 mo (28 d)9.01045.008.99050.00b
    Birth to 7 mo (214 d)101.130190.83d103.540187.50c
    Birth to 20 mo (609 d)133.580300.00137.000262.50
Case-children with AD (n = 187) vs controls (n = 724)
    Prenatal2.96062.752.280100.00
    Birth to 1 mo (28 d)9.40045.009.01050.00
    Birth to 7 mo (214 d)101.420190.83104.650187.50
    Birth to 20 mo (609 d)134.640253.33138.540262.50
Case-children with ASD with regression (n = 49) vs controls (n = 652)
    Prenatal3.34025.001.86037.75
    Birth to 1 mo (28 d)9.08045.008.92050.00
    Birth to 7 mo (214 d)101.090190.83103.280187.50
    Birth to 20 mo (609 d)140.120253.33136.800262.50
  • Ethylmercury from thimerosal-containing vaccines and immunoglobulins. For descriptive purposes, the postnatal exposure amounts shown here were not divided by weight at time of vaccine receipt. Most vaccines in use at the time that case-children were infants contained 0, 12.5, or 25 μg of ethylmercury per dose. Among case-children with ASD, mean prenatal ethylmercury exposure was 2.70 and ranged from 0 to 74 μg of ethylmercury from thimerosal-containing vaccines and immunoglobulins received by the mother during her pregnancy with the study child.

  • a Maximum from maternal receipt of 2 immunoglobulins during pregnancy, each containing 50 μg of ethylmercury.

  • b Maximum from child receipt of hepatitis B immunoglobulin (25 μg) and hepatitis B vaccine (12.5 μg) at birth and hepatitis B vaccine (12.5 μg) at 28 days of age.

  • c Maximum from child receipt of 3 hepatitis B (12.5 μg), 3 diphtheria-tetanus-acellular pertussis (25 μg), and 3 Hib (25 μg) vaccines in first 7 months.

  • d Maximum from child receipt of 2 hepatitis B (12.5 μg), 1 rabies (20 μg), 3 diphtheria-tetanus toxoids-pertussis (24.27, 23.28, and 23.28 μg), and 3 Hib (25 μg) vaccines in first 7 months.