TABLE 3

Drug Classes and E-codes Associated With ADEs by CCC Status, 2006–2010

Drug ClassCCC Visits (n = 2 830 657)Non-CCC Visits (n = 141 554 531)Likelihood of ADE in CCC vs non-CCC Visits
Weighted Frequency of ADEs a Estimated ADEs per 100 000 Visits (95% CI)Weighted Frequency of ADEs a Estimated ADEs per 100 000 Visits (95% CI)OR b (95% CI)
Total ADEs, n 62 1182194 (1884–2505)654 546462 (435–490)4.8 (4.4–5.1)
Psychotropics, n 11 433404 (371–437)22 32616 (15–17)23.6 (21.9–25.4)
 Antipsychotics (E9393)41%26%
 Psychostimulants (E9397)8%30%
 Antidepressants (E9390)8%18%
 Phenothiazines (E9391)17%5%
 Benzodiazepines (E9394)11%9%
 Other15%12%
Misc/not elsewhere classified c 8071285 (256–437)254 278180 (163–196)1.6 (1.5–1.7)
Antimicrobials7396261 (213–310)187 296132 (125–140)2.0 (1.8–2.2)
 Penicillins (E9300)16%46%
 Cephalosporins (E9305)15%12%
 Antibiotics NEC/NOS (E9308-9)46%18%
 Sulfonamides (E9310)7%10%
 Erythromycin (E9303)3%7%
 Other13%7%
Anticonvulsants6766239 (204–274)72315 (5–6)45.1 (40.9–49.9)
 Anticonvulsants NEC (E9363)75%79%
 Hydantoin derivatives (E9361)24%19%
 Other1%2%
Hormones/steroids5295187 (146–228)18 42413 (12–14)13.7 (12.1–15.7)
 Corticosteroids (E9320)92%71%
 Insulin/Anti-diabetics (E9323)3%17%
 Ovarian hormones (E9322)2%10%
 Other5%2%
Analgesics4210149 (120–178)35 47925 (24–27)5.5 (4.8–6.2)
 Opiates (E9352)66%40%
 Antirheumatics (E9356)7%26%
 Aromatic analgesics (E9354)5%16%
 Analgesics NEC/NOS (E9358-9)15%11%
 Salicylates (E9353)4%5%
 Other3%2%
Chemotherapy c , d 3981141 (81–201)14361 (1–1)138.7 (105.2–182.8)
Non–E-code c 2946104 (87–121)52 74937 (34–41)2.6 (2.2–2.9)
Sedatives/hypnotics/anesthetics c 276398 (78–117)82706 (5–6)16.2 (14.4–18.2)
Gastrointestinal agents186766 (57–75)83086 (5–6)10.8 (9.6–12.2)
 Antiemetics/allergics (E9330)83%75%
 Antacids (E9430)4%8%
 Other13%17%
Respiratory agents180664 (40–88)11 3538 (6–10)8.2 (6.1–11.0)
 Antiasthmatics (E9457)92%77%
 Antitussives (E9454)6%15%
 Other2%8%
Hematologic agents166859 (42–76)44593 (1–6)18.4 (8.7–39.1)
 Anticoagulants (E9342)28%74%
 γ globulin (E9346)23%16%
 Blood products (E9347)38%2%
 Iron and compounds (E9340)3%5%
 Other8%3%
Electrolytes/minerals/vitamins c 104237 (26–48)12381 (1–1)40.7 (32.5–51.1)
Autonomic agents86130 (25–36)41443 (3–3)9.9 (8.3–11.8)
 Sympathomimetics (E9412)35%53%
 Parasympathomimetics (E9411)31%21%
 Other34%26%
Cardiovascular agents91632 (26–39)22542 (1–2)19.4 (15.4–24.4)
 Antihypertensives (E9426)39%37%
 Cardiotonics (E9421)17%11%
 Rhythm regulators (E9420)15%5%
 Other29%47%
Musculoskeletal/topical agents c 58421 (16–26)11 1158 (7–9)2.6 (2.0–3.2)
Vaccines b 51318 (13–23)24 18617 (12–16)1.1 (0.9–1.4)
  • OR, odds ratio; CI, confidence interval.

  • a Percentages listed indicate the percent of the weighted frequency of ADEs for the particular drug class listed.

  • b Adjusted for age.

  • c Further subcategorization could not be reported because of inadequate sample size within each contained subcategory.

  • d Although malignancies were excluded, these cases either represent uncoded cases of malignancy or use of chemotherapy in the treatment of other conditions.