TABLE 16

Key Action Statement 3E: Clinicians may prescribe oral prednisolone or prednisone to treat IHs if there are contraindications or an inadequate response to oral propranolol (grade B, moderate recommendation).

Aggregate Evidence QualityGrade B
BenefitsModest benefit in IH clearance; medication cost is low
Risks, harm, costClinically important harms; cost associated with the evaluation and treatment of adverse effects
Intentional vaguenessNone
Benefit-harm assessmentBenefits outweigh harms
Role of patient preferenceShared decision-making regarding treatment
ExclusionsNone
StrengthModerate recommendation
Key references46,70,103