TABLE 2

Risk Factors for Increasing Severity and/or Intensity of NAS

DefiniteProbable
Term97,98,108Male gender112,113
Good birth weight97,109Methadone45,46
Polydrug abuse106,107, 110Smoking97,109,114
Combination with benzodiazepines97,111Combination with SSRIs97,109,115
μ-opioid receptor (OPRM1 118 AA) positive105
Catechol-O-methyltransferase (COMT 158 AA) positive105