TABLE 2

Differences in Opioid Treatments and Outcomes Comparing 6 Regional NAS Management Strategies

Region A, N = 102Region B, N = 183Region C, N = 187Region D, N = 29Region E, N = 32Region F, N = 14Total, N = 547
Protocol-driven weaningYesYesYesNoNoNo
Compliant with weaning protocola (N, %)102 (100%)172 (94.0%)143 (76.5%)417 (76.2%)
Opioid treatment days, mean ± SD14.3 ± 11.216.4 ± 10.222.6 ± 17.632.9 ± 16.031.1 ± 19.941.8 ± 18.020.5 ± 15.7
Day of life of discharge, mean ± SD20.5 ± 13.422.1 ± 10.420.7 ± 14.113.3 ± 6.637.1 ± 19.748.6 ± 18.822.4 ± 14.4
Number of drugs used to treat, mean ± SD1.3 ± 0.51.4 ± 0.71.7 ± 0.81.2 ± 0.41.5 ± 0.61.2 ± 0.41.5 ± 0.7
Treated with phenobarbital (N, %)29 (28.4%)49 (26.8%)85 (44.5%)2 (6.9%)14 (43.8%)0 (0.0%)179 (32.7%)
Treated with morphine only (N, %)102 (100%)5 (2.7%)130 (69.5%)9 (31.0%)32 (100%)0 (0.0%)278 (50.8%)
Treated with methadone only (N, %)0 (0.0%)151 (82.5%)43 (23%)17 (58.6%)0 (0.0%)13 (92.9%)224 (41.0%)
Treated with multiple opioids (N, %)0 (0.0%)12 (6.6%)14 (7.5%)3 (10.3%)0 (0.0%)1 (7.1%)30 (5.5%)
Home on oral morphine (N, %)0 (0.0%)0 (0.0%)0 (0.0%)9 (31.0%)0 (0.0%)0 (0.0%)9 (1.6%)
Home on methadone (N, %)0 (0.0%)0 (0.0%)39 (20.9%)19 (65.5%)0 (0.0%)0 (0.0%)58 (10.6%)
  • a Based on intention to treat according to weaning protocol.