TABLE 3

Prevalence of Mental Health Diagnoses in TGNC Adolescents Ages 10–17 Years Relative to Those in Referent Groups

Categories of Mental Health DisordersPrevalence in Transfeminine Subjects, N (%)PR (95% CI)a in Transfeminine SubjectsPrevalence in Transmasculine Subjects, N (%)PR (95% CI)a in Transmasculine Subjects
Versus Reference MalesVersus Reference FemalesVersus Reference MalesVersus Reference Females
All diagnoses of interest
 Ever before index date303 (71.0)3.0 (2.8–3.3)3.6 (3.3–3.9)488 (74.5)3.0 (2.8–3.2)3.7 (3.4–3.9)
 6 mo before index date253 (59.3)7.8 (6.8–8.9)8.6 (7.5–9.8)429 (65.5)7.8 (7.1–8.7)8.7 (7.8–9.6)
Anxiety disorders
 Ever before index date159 (37.2)5.0 (4.2–5.8)4.2 (3.6–4.9)255 (38.9)4.9 (4.3–5.6)4.0 (3.5–4.5)
 6 mo before index date106 (24.8)18.0 (13.3–24.4)9.2 (7.2–11.8)175 (26.7)15.7 (12.5–19.6)8.7 (7.2–10.5)
Attention deficit disorders
 Ever before index date107 (25.1)2.0 (1.7–2.4)5.3 (4.3–6.5)106 (16.2)1.3 (1.0–1.5)3.3 (2.7–4.1)
 6 mo before index date68 (15.9)3.8 (2.9–4.9)9.0 (6.6–12.4)69 (10.5)2.5 (1.9–3.3)6.4 (4.6–8.8)
Autism spectrum disorders
 Ever before index date31 (7.3)4.1 (2.6–6.4)25.2 (12.7–52.9)24 (3.7)1.8 (1.1–2.8)7.6 (4.3–13.5)
 6 mo before index date25 (5.9)8.1 (4.6–14.3)260.8 (42.5–10 733.9)17 (2.6)3.4 (1.8–6.1)17.2 (7.4–42.1)
Bipolar disorders
 Ever before index date23 (5.4)9.9 (5.3–18.5)10.3 (5.5–19.5)34 (5.2)8.6 (5.2–13.9)8.0 (4.9–12.9)
 6 mo before index date16 (3.8)18.1 (7.5–46.9)14.8 (6.4–35.6)19 (2.9)11.3 (5.5–23.3)14.8 (6.9–32.8)
Conduct and/or disruptive disorders
 Ever before index date60 (14.1)2.8 (2.1–3.7)6.6 (4.8–9.0)59 (9.0)1.7 (1.3–2.3)4.5 (3.2–6.2)
 6 mo before index date22 (5.2)5.3 (3.0–9.1)12.6 (6.4–25.2)27 (4.1)5.5 (3.3–9.0)10.6 (5.9–19.1)
Depressive disorders
 Ever before index date207 (48.5)5.8 (5.1–6.7)4.4 (3.9–5.0)403 (61.5)7.0 (6.4–7.8)5.7 (5.2–6.2)
 6 mo before index date172 (40.3)23.5 (18.2–30.4)10.1 (8.4–12.2)326 (49.8)22.8 (19.0–27.3)13.3 (11.5–15.4)
Eating disorders
 Ever before index date18 (4.2)7.7 (3.9–14.9)3.3 (1.8–5.7)28 (4.3)6.0 (3.6–9.8)3.2 (2.0–5.0)
 6 mo before index date11 (2.6)18.5 (6.2–61.2)6.1 (2.6–13.8)19 (2.9)27.5 (11.0–77.6)8.7 (4.4–17.0)
Psychoses
 Ever before index date19 (4.5)19.5 (8.6–47.3)12.2 (5.9–25.5)32 (4.9)12.2 (7.0–21.3)14.4 (8.1–25.9)
 6 mo before index date10 (2.3)20.1 (6.2–75.4)100.6 (14.2–4375.0)18 (2.8)22.7 (9.4–60.6)30.4 (11.5–93.8)
Personality disorders
 Ever before index date10 (2.3)14.4 (4.9–44.7)11.2 (4.1–31.2)15 (2.3)11.6 (5.1–26.6)7.9 (3.7–16.6)
 6 mo before index dateb19.8 (2.8–220.0)19.8 (2.8–219.9)9 (1.4)29.9 (7.4–172.1)29.9 (7.4–172.4)
Schizophrenia spectrum disorders
 Ever before index date5 (1.2)49.7 (5.5–2357.0)24.9 (4.1–261.7)13 (2.0)21.7 (7.7–69.9)32.6 (10.0–137.8)
 6 mo before index datebc14.8 (1.7–178.2)10 (1.5)99.8 (14.2–4338.3)50.0 (10.6–470.2)
Self-inflicted injuries
 Ever before index date11 (2.6)3.9 (1.8–8.2)4.1 (1.8–8.6)54 (8.2)14.0 (9.1–21.8)8.7 (5.9–12.8)
 6 mo before index date7 (1.6)69.9 (9.0–3159.2)17.5 (4.4–81.7)28 (4.3)143.7 (36.1–1247.8)20.5 (10.4–42.4)
Substance use disorders
 Ever before index date33 (7.7)3.0 (1.9–4.5)3.7 (2.4–5.6)46 (7.0)2.4 (1.7–3.4)3.3 (2.3–4.7)
 6 mo before index date24 (5.6)5.8 (3.3–9.8)8.9 (4.9–16.0)34 (5.2)4.5 (2.9–6.9)8.2 (5.0–13.2)
Suicidal ideation
 Ever before index date32 (7.5)17.8 (9.7–33.6)11.3 (6.5–19.4)68 (10.4)21.2 (13.8–33.2)11.0 (7.7–15.9)
 6 mo before index date21 (4.9)54.2 (18.2–218.3)31.0 (12.6–86.7)47 (7.2)45.2 (22.9–97.1)24.9 (14.3–44.6)
  • a Logistic regression with exact 95% CIs for rare events (prevalence ≤10% in both the transgender and referent cohorts) or logistic regression with log link and approximate 95% CIs for not-rare events (>10% prevalence in either the transgender or referent cohorts).

  • b Fewer than 5 cases were not reported.

  • c Not calculated because there were 0 cases among referents.