TABLE 1

Parameters of the Fragility Index (2-Parameter Logistic Rasch Model) comprising Problematic Events During Pregnancy, Birth, or the Neonatal Period Before Randomization in the Original RCT Cohort

ParameterDifficultya
Preterm1.8972291
Intrauterine growth restriction−0.5855773
Intrauterine growth restriction and preterm−1.2851473
Gestational age at birth−0.7523441
Acute suffering at birth0.3160136
Neonatal reanimation−1.8858323
Weight at birth <1501 g−1.7757791
Toxemia during pregnancy−0.3618344
Primiparous−0.1795824
Apgar score 5 min <7−0.6533428
Male sex−0.1965165
Neonatal sepsis−1.7442807
Gestational age at randomization−2.162849
Nosocomial infection before randomization−1.7062807
Severe jaundice−0.5502986
  • a An easy indicator (negative value) is any observed fragility; a difficult indicator (positive value) is seen only at the most severe levels.