TABLE 1

List of Studies Identified and Selected Through Database Searches

First Author and ReferenceStudy TypePatients Treated With Propranolol, nSex, nAge at Treatment Initiation, moType or Localization of IH
FemaleMaleMeanMedianMinMax
Ábarzúa-Araya26RCT, noninferiority of propranolol versus atenolol10“Problematic” IH; various loc
Al Dhaybi31Retrospective181343.7131Periocular IH incl PHACES
Albuquerque32Retrospective69462331.081228Various loc incl PHACES
Andersen33Retrospective372890.122Complicated IH; various loc
Bagazgoitia34Retrospective7156155.8145“Problematic” IH; various loc excl PHACES
Balma-Mena35Retrospective4432127.8Various loc
Bauman24RCT, propranolol versus prednisolone10 (+1 patient withdrawn before treatment)832.51.73.4Symptomatic IH; various loc incl PHACES
Ben-Amitaï36Retrospective10646.3222Isolated nasal tip IH
Bernabeu-Wittel37Prospective281.432.7Severe IH; various loc incl PHACES
Bertrand38Retrospective353143.51120Problematic IH; various loc incl PHACES
Betlloch-Mas39Prospective201735.2219Complicated IH; various loc excl PHACES
Blatt40Retrospective5440.126Various loc incl PHACES
Buckmiller41Retrospective412757.11.530Problematic IH; various loc
Celik42Prospective6731367.0124Problematic IH; various loc
Chai43Prospective272164.10.77“Problematic” IH; various loc excl PHACES
Cheng44Retrospective10737.8123Periorbital IH
Chik45Retrospective121027222“Problematic” IH; various loc
Claerhout46Prospective106.8219Periocular IH
Corapcioğlu47Prospective12934.5“Problematic” IH (with resistance to corticotherapy); various loc
Cushing48Retrospective443595.80.749.2“Problematic” IH; various loc
Dyme49Retrospective153.81.88.4“Problematic” IH; various loc
El Ezzi50Retrospective292183.51.512Complicated and problematic IH; various loc
El-Essawy51Prospective151148.1Periorbital or orbital IH
Erbay52Prospective161333.6−1.125.2Complicated IH; various loc
Fuchsmann53Retrospective3927124.1111“Problematic” head and neck IH
Gan30Retrospective1096742Various loc
Georgountzou54Prospective282085.95216Problematic IH; various loc
Giachetti55Retrospective300.514“Problematic” IH; various loc
de Graaf19Prospective282178.8243“Problematic” IH; various loc incl PHACES
Haider56Retrospective170.712Periocular IH
Harper57Prospective302735.8Complicated IH; various loc
Hasan58Prospective36261025.750.7120“Problematic” IH; various loc
Hassan59Prospective302193.7212Complicated (or huge); various loc
Hermans60Retrospective201553.5Ulcerating IH; various loc
Hermans29Prospective174123514.80.92.9Complicated IH; various loc
Hogeling23RCT, propranolol versus placebo1914515.52.160“Problematic” IH; various loc
Holmes61Prospective312383.91.29.7Problematic IH; various loc
Hong62Retrospective4527183.50.55.5Severe IH; head and neck IH
Hsu63Retrospective131034111“Problematic” IH; various loc
Javia64Retrospective1293317Laryngotracheal IH (incl PHACES)
Jian65Retrospective9765327.2318Cavernous or mixed IH
Kagami66Prospective151232.61.23.9Various loc
Katona67Retrospective221753.718Head and neck IH
Küpeli68Retrospective149540.1536“Problematic” IH; various loc
Laforgia69Prospective231584.0113Severe IH; various loc (incl PHACES)
Leboulanger70Retrospective141315.20.716Laryngotracheal (incl PHACES)
Liu71Retrospective312294.60.521Problematic IH
Luo27Retrospective6354312040.536Various loc
Lv72Retrospective3727102.81.58Problematic head and neck IH
Lynch73Prospective4434104.30.910.8Complicated IH; various loc (incl PHACES)
Ma74Prospective8952373.6112Various loc
Mahadevan75Prospective10732.724Subglottic IH
Malik25RCT, propranolol versus prednisolone versus propranolol+prednisolone208124.718Problematic IH; various loc
Manunza76Prospective302735.81.213.5Complicated IH; various loc (incl PHACES)
McGee77Retrospective241952.81.817“Problematic” IH; various loc (incl PHACES)
McSwiney78Prospective201555.51.850Various loc (excl PHACES)
Meng79Prospective221395.51.515Facial IH
Metry80Retrospective324.80.224PHACES with cervical and intracranial arterial anomalies
Missoi81Retrospective171254.52.25.6Periocular IH (incl PHACES)
Ozyörük82Retrospective14954116Complicated IH; various loc
Park83Retrospective8360235.4141Problematic IH; various loc
Phillips28Retrospective188143454.00.284“Problematic” IH; various loc (incl PHACES)
Price9Retrospective684.9Various loc
Puttgen84Retrospective5039114.00.812Symptomatic IH; various loc
Rössler85Retrospective302194.4“Problematic” IH; various loc
Sadykov86Prospective7156155.8145Problematic maxillofacial IH (excl PHACES)
Sagi87Retrospective9980199.4254“Problematic” IH; various loc
Saint-Jean88Retrospective3323105.2216Ulcerated IH; various loc
Sans6Prospective3221114.2“Problematic” (severe) IH; various loc
Schiestl89Retrospective251693.61.59.1Problematic IH; various loc
Schupp90Prospective5540156.41.235.5(Severe) IH; various loc
Snir91Retrospective302285.0117Periocular IH
Sondhi22OCT versus historical control3122951108“Problematic”; various loc (excl PHACES)
Szychta92Prospective604.9“Problematic”; various loc (excl PHACES)
Tan93Prospective152.50.78.5Problematic IH; various loc
Vassallo94Prospective147720.9296“Problematic” eyelid IH
Vercellino95Prospective684919Complicated IH (incl PHACES)
Weiss96Retrospective11Parotid IH
Xiao21Prospective6451133.60.59.1“Problematic” IH; various loc
Yuan97Prospective3523126.0212Various loc
Zaher98Prospective302196.0212Problematic IH; various loc
Zegpi-Trueba99Prospective5746119.7279“Problematic” IH; various loc
Zvulunov100Retrospective4237528.07120IH beyond proliferation phase
  • excl, excluding; incl, including; loc, localizations; Max, Maximum; Min, minimum; OCT, open clinical trial; PHACES, posterior fossa brain anomalies, hemangiomas, arterial anomalies, and cardiac defects and coarctation of the aorta, eye abnormalities, and sternal abnormalities or ventral developmental defects; "Problematic" when set in quotation marks is not used in the original article and has been chosen as generic qualifier of IH type when appropriate; RCT, randomized controlled trial.