TABLE 3

Dosing Error by Dosing Tool Type and Randomization Group, Stratified by Health Literacy and Language (n = 2058)

% Trials With Errors/ParentaDosing Error (>20% deviation)
PbaORc95% CIP
By Health Literacy
Low health literacy (n = 740)
Unit of measurement pairing on label vs dosing tool
GroupLabel UnitTool Unit
1mLmL32.4.031.0RefRef
2mL and tspmL and tsp28.50.80.6–1.1.2
3mL and teaspoonmL and tsp30.20.90.7–1.2.4
4mLmL and tsp31.91.00.7–1.3.9
5teaspoonmL and tsp38.71.30.98–1.7.07
 Dosing tool type
  Cup48.9<.0013.43.0–3.9<.001
  Syringe (0.2-mL increment, 10-mL capacity)24.91.10.98–1.2.1
  Syringe (0.5-mL increment, 10-mL capacity)23.61.0RefRef
Marginal health literacy (n = 843)
Unit of measurement pairing on label vs dosing tool
GroupLabel UnitTool Unit
1mLmL21.8.21.0RefRef
2mL and tspmL and tsp21.50.90.7–1.2.6
3mL and teaspoonmL and tsp22.20.970.7–1.3.8
4mLmL and tsp24.51.10.9–1.5.4
5teaspoonmL and tsp28.61.30.95–1.7.1
 Dosing tool type
  Cup43.1<.0015.64.8–6.6<.001
  Syringe (0.2-mL increment, 10-mL capacity)13.81.00.9–1.2.8
  Syringe (0.5-mL increment, 10-mL capacity)13.71.0RefRef
Adequate health literacy (n = 475)
Unit of measurement pairing on label vs dosing tool
GroupLabel UnitTool Unit
1mLmL20.3.21.0RefRef
2mL and tspmL and tsp16.30.90.6–1.3.5
3mL and teaspoonmL and tsp14.00.70.5–1.01.1
4mLmL and tsp14.60.70.5–1.05.1
5teaspoonmL and tsp18.80.90.7–1.4.7
 Dosing tool type
  Cup33.6<.0016.55.0–8.5<.001
  Syringe (0.2-mL increment, 10-mL capacity)8.20.90.7–1.2.4
  Syringe (0.5-mL increment, 10-mL capacity)8.81.0RefRef
By Language
English (n = 1334)
Unit of measurement pairing on label vs dosing tool
GroupLabel UnitTool Unit
1mLmL25.60.21.0RefRef
2mL and tspmL and tsp22.00.80.7–1.02.07
3mL and teaspoonmL and tsp21.30.80.6–0.96.02
4mLmL and tsp23.70.90.7–1.06.2
5teaspoonmL and tsp25.20.90.7–1.1.4
 Dosing tool type
  Cup42.0<.0015.24.5–5.9<.001
  Syringe (0.2-mL increment, 10-mL capacity)14.21.00.9–1.1.8
  Syringe (0.5-mL increment, 10-mL capacity)14.31.0RefRef
Spanish (n = 724)
Unit of measurement pairing on label vs dosing tool
GroupLabel UnitTool Unit
1mLmL24.9<.0011.0RefRef
2mL and tspmL and tsp24.11.00.8–1.3.9
3mL and teaspoonmL and tsp26.51.10.8–1.4.7
4mLmL and tsp28.71.20.9–1.6.2
5teaspoonmL and tsp38.32.01.5–2.6<.001
 Dosing tool type
  Cup44.7<.0013.93.3–4.5<.001
  Syringe (0.2-mL increment, 10-mL capacity)20.81.10.98–1.2.1
  Syringe (0.5-mL increment, 10-mL capacity)19.51.0RefRef
  • Ref, referent.

  • a Percentage of trials with dosing errors per parent.

  • b Type 3 χ2 from full model.

  • c Full model adjusting for randomization group, tool type, dose amount, dosing order, language, and health literacy. Models by health literacy adjusting for all except health literacy; models for language adjusting for all except language.