TABLE 7

Performance of M-CHAT and M-CHAT/F Screens Predicting ASD or Suspected ASD Diagnosis and/or Developmental Delay Diagnosis

VariableNaRatio (95% CI)z Test, PTOST
z1 Pz2P
PPVb.01.74<.001
 M-CHAT980.77 (0.68–0.85)
 PCP M-CHAT/F980.90 (0.84–0.96)
PPVc.90.01.008
 PCP M-CHAT/F980.90 (0.84–0.96)
 AC M-CHAT/F970.89 (0.83–0.96)
Sensitivityc.77.13.05
 PCP M-CHAT/F980.48 (0.38–0.58)
 AC M-CHAT/F970.46 (0.36–0.56)
Specificityc.99.03.03
 PCP M-CHAT/F980.83 (0.75–0.90)
 AC M-CHAT/F970.83 (0.75–0.90)
Accuracyc.84.12.05
 PCP M-CHAT/F980.56 (0.46–0.66)
 AC M-CHAT/F970.55 (0.45–0.65)
  • Predictions include suspected ASD/new phenotype. Developmental Delay Positive was defined as >1.5 SDs below the mean on ≥2 Mullen scales or >2 SDs below the mean on ≥1 Mullen scale. Comparisons were made with 2-tailed z test and TOST, Δ = 0.1 unit of proportion. Only patients with a positive screen on the M-CHAT are included in this sample. CI, confidence interval.

  • a One patient did not have a complete AC M-CHAT/F (Fig 1).

  • b Trivial difference.

  • c Equivalence.