TABLE 6

Performance of M-CHAT and M-CHAT/F Screens Predicting ASD and/or Developmental Delay Diagnosis

VariableNaRatio (95% CI)z Test, PTOST
z1 Pz2P
PPVb.001.94<.001
 M-CHAT980.68 (0.59–0.78)
 PCP M-CHAT/F980.88 (0.81–0.94)
PPVc.51.09.004
 PCP M-CHAT/F980.88 (0.81–0.94)
 AC M-CHAT/F970.84 (0.62–0.80)
Sensitivityc.60.19.03
 PCP M-CHAT/F980.52 (0.42–0.62)
 AC M-CHAT/F970.48 (0.39–0.58)
Specificityc.56.11.008
 PCP M-CHAT/F980.84 (0.77–0.91)
 AC M-CHAT/F970.81 (0.73–0.89)
Accuracyc.62.18.03
 PCP M-CHAT/F980.62 (0.53–0.72)
 AC M-CHAT/F970.59 (0.49–0.69)
  • Developmental Delay Positive was defined as >1.5 SDs below the mean on ≥2 Mullen scales or >2 SDs below the mean on ≥1 Mullen scale. Comparisons were made with 2-tailed z test and TOST, Δ = 0.1 unit of proportion. Only patients with a positive screen on the M-CHAT are included in this sample. CI, confidence interval.

  • a One patient did not have a complete AC M-CHAT/F (Fig 1).

  • b Trivial difference.

  • c Equivalence.