TABLE 3

Clinical Effects Associated With Nicotine and Tobacco Product Exposures Among Children Younger Than 6 Years, NPDS, January 2012 to April 2015

Clinical EffectType of Nicotine and Tobacco ProductClinical Effect Total, n (%a)
E-cigarette, n (%a)Cigarette, n (%a)Other, n (%a)Unknown, n (%a)
Cardiovascular
 Tachycardia62 (1.5)37 (0.2)21 (0.4)33 (1.2)153 (0.5)
 Hypotension2 (0.0)1 (0.0)0 (0.0)0 (0.0)3 (0.0)
 Bradycardia1 (0.0)0 (0.0)1 (0.0)0 (0.0)2 (0.0)
 Asystole1 (0.0)0 (0.0)0 (0.0)0 (0.0)1 (0.0)
 Cardiac arrest1 (0.0)0 (0.0)0 (0.0)0 (0.0)1 (0.0)
Dermal
 Pallor45 (1.1)113 (0.6)139 (2.9)28 (1.0)325 (1.1)
 Erythema/flushed41 (1.0)13 (0.1)7 (0.1)10 (0.4)71 (0.2)
 Irritation/pain6 (0.1)0 (0.0)0 (0.0)3 (0.1)9 (0.0)
Gastrointestinal
 Vomiting721 (17.5)3497 (20.0)1595 (33.4)596 (21.9)6409 (22.0)
 Nausea79 (1.9)278 (1.6)222 (4.6)67 (2.5)646 (2.2)
 Oral irritation48 (1.2)28 (0.2)36 (0.8)8 (0.3)120 (0.4)
 Abdominal Pain14 (0.3)18 (0.1)35 (0.7)25 (0.9)92 (0.3)
 Diarrhea5 (0.1)29 (0.2)12 (0.3)7 (0.3)53 (0.2)
Neurologic
 Drowsiness/lethargy93 (2.3)187 (1.1)183 (3.8)56 (2.1)519 (1.8)
 Agitated/irritable42 (1.0)155 (0.9)59 (1.2)27 (1.0)283 (1.0)
 Dizziness/vertigo15 (0.4)16 (0.1)36 (0.8)10 (0.4)77 (0.3)
 Ataxia20 (0.5)19 (0.1)30 (0.6)7 (0.3)76 (0.3)
 Tremor12 (0.3)26 (0.1)25 (0.5)13 (0.5)76 (0.3)
 Confusion4 (0.1)6 (0.0)6 (0.1)3 (0.1)19 (0.1)
 Seizure (single)2 (0.0)1 (0.0)0 (0.0)3 (0.1)6 (0.0)
 Coma4 (0.1)2 (0.0)0 (0.0)0 (0.0)6 (0.0)
 Syncope1 (0.0)0 (0.0)2 (0.0)0 (0.0)3 (0.0)
Ocular
 Irritation/pain94 (2.3)8 (0.0)30 (0.6)16 (0.6)148 (0.5)
 Red eye/conjunctivitis63 (1.5)7 (0.0)19 (0.4)8 (0.3)97 (0.3)
 Burns0 (0.0)1 (0.0)0 (0.0)0 (0.0)1 (0.0)
Respiratory
 Cough/choke109 (2.6)462 (2.6)154 (3.2)26 (1.0)751 (2.6)
 Cyanosis3 (0.1)1 (0.0)2 (0.0)0 (0.0)6 (0.0)
 Respiratory depression2 (0.0)1 (0.0)1 (0.0)0 (0.0)4 (0.0)
 Respiratory arrest3 (0.1)0 (0.0)0 (0.0)0 (0.0)3 (0.0)
 Abnormal radiograph findings1 (0.0)0 (0.0)0 (0.0)0 (0.0)1 (0.0)
Miscellaneous
 Diaphoresis14 (0.3)43 (0.2)47 (1.0)16 (0.6)120 (0.4)
 Other56 (1.4)171 (1.0)105 (2.2)30 (1.1)362 (1.2)
Total Exposures (row %b)4128 (14.2)17 512 (60.1)4778 (16.4)2723 (9.3)29 141 (100.0)
  • a Column percentages will not sum to 100.0% because an exposed child may or may not experience ≥1 clinical effects.

  • b Row percentages may not sum to 100.0% due to rounding error.