TABLE 3

Hazard Ratios (95% CIs) for Cancer for Phototherapy and Other Perinatal Risk Factors Identified Using Backward Stepwise Cox Models With P < .1a

Risk FactorAny Cancer (N = 711)Any Leukemia (N = 223)Lymphocytic Leukemia (N = 169)Nonlymphocytic Leukemia (N = 54)Kidney Cancer (N = 26)Bone Cancer (N = 13)Liver Cancer (n = 12)
Any phototherapy1.28 (0.92–1.77)1.33 (0.94–1.89)1.15 (0.80–1.67)1.09 (0.64–1.84)1.34 (0.70–2.56)3.30 (0.60–18.3)3.44b (1.13–10.5)
Down syndrome14.4c (9.41–22.2)45.9c (30.0–70.2)31.1c (14.0–69.5)139c (66.0–293)NININI
Other chromosomal disorders4.71c (2.71–8.20)2.70b (1.14–6.36)NININI30.0c (9.19–97.9)34.8c 8.29–146)
Congenital anomalies1.52b (1.11–2.08)NININI8.79c (3.23–23.9)3.27d (0.95–11.3)NI
Apgar <7 at 5 min1.91b (1.06–3.43)2.69b (1.18–6.13)2.54d (0.86–7.54)NININI7.08b (1.73–29.0)
Male genderNI1.29e (1.10–1.51)1.46e (1.17–1.82)NININI0.44d (0.18–1.07)
Maternal age ≥35 yNININI0.49b (0.25–0.95)NININI
Early jaundiceNI1.75b (1.19–2.59)NI3.28e (1.61–6.66)NININI
Any TSB > AAP phototherapy thresholdNININI2.13d (0.95–4.75)2.09d (0.97–4.49)NINI
  • NI, not included in model; P ≥ .1

  • a Hazard ratios are included for all risk factors with P < .1 except for the 6 birth wt and 5 race categories. Not shown: High birth wt was significantly associated with any cancer, any leukemia, lymphocytic leukemia, and kidney cancer (all P < .0005), and black race was associated with decreased risk of any cancer relative to white race (HR = 0.73; P = .05). Complete models are provided in the Supplemental Information.

  • b .005 < P < .05. The P value for any phototherapy and liver cancer was .03.

  • c P < .0005.

  • d .05 < P < .1.

  • e .0005 < P < .005.