TABLE 3

Regimens for PCP Prophylaxis in Infants37

DrugDoseRouteSchedule
Trimethoprim-sulfamethoxazoleTrimethoprim 150 mg/m2 per d, with sulfamethoxazole 750 mg/m2 per dPOTwice daily for 3 d/wk on consecutive days (eg, Monday, Tuesday, and Wednesday) or on alternate days (eg, Monday, Wednesday, and Friday); alternatives: once daily for 3 d/wk or twice daily 7 d/wk
Dapsone2 mg/kgPOOnce daily
4 mg/kgPOOnce weekly
Pentamidine4 mg/kgIVEvery 2–4 wk
Atovaquone
Infants 1–3 mo old30 mg/kgPOOnce daily
Infants 4–24 mo old45 mg/kgPOOnce daily
  • For further discussion, see “Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV-Exposed and Infected Children.”37 PO indicates per os (by mouth); IV, intravenous.