TABLE 1

Newborn Infant ZDV Dose for Prophylaxis of MTCT of HIV-115,16

Gestational Age at BirthOral Dose, mg/kg per DoseIntravenous Dose, mg/kg per DoseDosing FrequencyDuration, wk
≥35 wk21.5Every 6 ha6
>30 wk but <35 wk21.5Every 12 h, advancing to every 8 h at 2 wk of age6
<30 wk21.5Every 12 h, advancing to every 8 h at 4 wk of age6
  • a Although there are no definitive data in infants to show pharmacokinetic equivalence or equal therapeutic efficacy of administration of double the standard oral ZDV dose twice daily, for term infants administration of ZDV 4 mg/kg per dose twice daily instead of 2 mg/kg per dose every 6 hours may increase adherence to the regimen and could be considered when there are concerns about adherence to drug administration to the infant.26,77,78