TABLE 1

Health Supervision Guidelines for Children With Neurofibromatosis

PrenatalInfancy (1 mo to 1 y)Early Childhood (1 to 5 y)Late Childhood (5 to 13 y), AnnualaAdolescence (13 to 21 y), Annuala
Neonatal2 mo4 mo6 mo9 mo12 mo15 mo18 mo24 mo3 ya4 ya
Diagnosis
    DNA analysisXb
    Phenotype reviewXcX
    Genetic counselingXcXXd
Reproductive options for parents
    Adoption/terminationX
    Future reproductive planningXXXXd
Anticipatory guidance
    Family supportXXXXXXXXXXXXXX
    Support groupsXXXXXdXd
    Long-term planningXXXXdXd
    Sexual and reproductive issuesXdX
Medical evaluation and treatmente
    GrowthOOOOOOOOOOOOO
    Blood pressureOOOOOOOOOOOOO
    Skin examinationOOOOOOOOOOOOO
    Bone examination/scoliosisOOOOOOOOOOOOO
    Neurologic examinationOOOOOOOOOOOOO
    Vision screeningS/OS/OS/OS/OS/OS/OfSSS/OfS/OfS/OfS/OfS/Of
    Hearing screeningSSSSSS/OfSSSSS/OfS/OS/O
    Sexual maturationOO
Diagnostic imaging examinationse
Psychosocial evaluation
    Development and behaviorS/OS/OS/OS/OS/OS/OS/OS/OS/OS/OS/OfS/OS/O
    Preschool programSS
    School placement/performanceS/OS/O
    Psychological/social adjustmentSSSSSSSS
    Intrafamily relationshipsSSSSSSSSSS
  • X indicates to be performed; S, subjective, by history; O, objective, by a standard testing method.

  • a Advise semiannual visits, as indicated.

  • b See “Discussion.”

  • c Or at the time of diagnosis.

  • d Once in this time period.

  • e As needed for significant abnormalities and/or new signs.

  • f Refer to subspecialist.