TABLE 2

Associations Between Introduction of Solids and Atopic Conditions at 6 Years of Age: Results From Multivariate Analysis

ParameterAll Children, aOR (95% CI)aChildren Without Early Skin or Allergic Symptoms, aOR (95% CI)a
First introduction of any solidsb
    Doctor diagnosis of eczema
        4–6 mo0.92 (0.61–1.39)0.71 (0.39–1.33)
        >6 mo0.82 (0.49–1.40)0.44 (0.18–1.08)
    Eczema symptoms
        4–6 mo0.92 (0.51–1.68)0.60 (0.24–1.51)
        >6 mo1.27 (0.63–2.58)0.51 (0.15–1.70)
    Doctor diagnosis of asthma
        4–6 mo0.86 (0.38–1.96)1.10 (0.36–3.32)
        >6 mo1.11 (0.42–2.96)1.20 (0.31–4.70)
    Asthma symptoms
        4–6 mo0.90 (0.61–1.32)0.76 (0.46–1.27)
        >6 mo0.81 (0.50–1.32)0.77 (0.40–1.46)
    Doctor diagnosis of allergic rhinitis
        4–6 mo1.35 (0.74–2.46)1.12 (0.42–2.99)
        >6 mo1.19 (0.56–2.53)1.45 (0.45–4.63)
    Allergic rhinitis symptoms
        4–6 mo0.90 (0.65–1.25)1.01 (0.63–1.60)
        >6 mo0.78 (0.50–1.20)0.63 (0.33–1.21)
    Food sensitization
        4–6 mo2.15 (1.28–3.62)3.13 (1.45–6.74)
        >6 mo1.88 (0.98–3.58)3.01 (1.19–7.61)
    Inhalant sensitization
        4–6 mo1.16 (0.81–1.67)0.92 (0.57–1.49)
        >6 mo1.30 (0.82–2.05)1.01 (0.54–1.87)
Solids diversity at 4 moc
    Doctor diagnosis of eczema
        1–2 groups1.01 (0.62–1.62)1.00 (0.45–2.20)
        3–8 groups1.43 (0.83–2.45)2.72 (1.24–5.99)
    Eczema symptoms
        1–2 groups1.13 (0.60–2.13)1.62 (0.59–4.48)
        3–8 groups0.64 (0.25–1.67)1.38 (0.33–5.74)
    Doctor diagnosis of asthma
        1–2 groups1.31 (0.57–2.99)1.38 (0.47–4.02)
        3–8 groups0.32 (0.07–1.52)0.27 (0.03–2.36)
    Asthma symptoms
        1–2 groups1.05 (0.68–1.63)1.27 (0.72–2.24)
        3–8 groups1.33 (0.80–2.20)1.53 (0.79–2.96)
    Doctor diagnosis of allergic rhinitis
        1–2 groups0.73 (0.36–1.46)0.48 (0.13–1.76)
        3–8 groups0.62 (0.25–1.53)1.03 (0.29–3.70)
    Allergic rhinitis symptoms
        1–2 groups1.29 (0.90–1.85)1.27 (0.76–2.11)
        3–8 groups1.00 (0.63–1.59)0.92 (0.47–1.79)
    Food sensitization
        1–2 groups0.38 (0.19–0.73)0.34 (0.13–0.86)
        3–8 groups0.49 (0.24–0.98)0.26 (0.09–0.72)
    Inhalant sensitization
        1–2 groups0.77 (0.51–1.17)0.93 (0.53–1.65)
        3–8 groups0.93 (0.57–1.50)1.45 (0.78–2.70)
  • aOR indicates adjusted odds ratio; CI, confidence interval.

  • a Odds ratios with 95% confidence interval adjusted for study center, parental allergy, gender, parental education, and breastfeeding type.

  • b Reference group: first introduction of any solids within the first 4 months.

  • c Reference group: no introduction of solids within the first 4 months.